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Molecular targets, DNA breakage, DNA repair: Their roles in mutation induction in mammalian germ cells

Description: Variability in genetic sensitivity among different germ-cell stages in the mammal to various mutagens could be the result of how much chemical reaches the different stages, what molecular targets may be affected in the different stages and whether or not repair of lesions occurs. Several chemicals have been found to bind very strongly to protamine in late-spermatid and early-spermatozoa stages in the mouse. The chemicals also produce their greatest genetic damage in these same germ-cell stages.… more
Date: January 1, 1989
Creator: Sega, G.A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Inhalation developmental toxicology studies: Teratology study of n-hexane in rats: Final report

Description: The straight chain hydrocarbon, n-hexane, is a volatile, ubiquitous solvent used in industrial, academic, and smaller commercial environments. The significant opportunity for women of child-bearing age to be exposed to this chemical prompted the undertaking of a study to assess the developmental toxicity of n-hexane in an animal model. Timed-pregnant (30 animals per group) and virgin (10 animals per group) Sprague-Dawley rats were exposed to 0 (filtered air), 200, 1000, and 5000 ppM n-hexane (9… more
Date: December 1, 1987
Creator: Mast, T.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Proton-induces and x-ray induced fluorescence analysis of scoliotic tissue

Description: Adolescent idiopathic scoliosis is characterized by a curvature or assymetry of the spine which may become progressively more severe, with clinical symptoms appearing just prior to, or during, puberty. The incidence for scoliosis in the age group from 12 to 14 years of age has been reported as high as 8 to 10%, with more than 80% of the cases occurring in females. Although pathologic changes exist in muscles from both sides of the spinal curvature, and no statistically significant side differen… more
Date: February 1, 1980
Creator: Panessa-Warren, B. J.; Kraner, H. W.; Jones, K. W. & Weiss, L. S.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Congenital malformation and fetal mortality trends in counties surrounding Oak Ridge

Description: Stillbirth and congenital malformation death data have been evaluated for counties surrounding the Oak Ridge nuclear facilities. The observed values were compared with expected values, based on state of Tennessee and East Tennessee rates, for three time periods: prior to the existence of the nuclear facilities; the early years of operation; and the later years of operation. Oak Ridge, which is the closest city to the nuclear facilities, had significantly fewer stillbirths and no difference in c… more
Date: December 1, 1979
Creator: Shank, K. E.; Easterly, C. D. & Oakes, T. W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Disruption of NBS1 gene leads to early embryonic lethality in homozygous null mice and induces specific cancer in heterozygous mice

Description: Nijmegen breakage syndrome (NBS) is a rare autosomal recessive chromosome instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition, with cellular features similar to that of ataxia telangiectasia (AT). NBS results from mutations in the mammalian gene Nbs1 that codes for a 95-kDa protein called nibrin, NBS1, or p95. To establish an animal model for NBS, we attempted to generate NBS1 knockout mice. However, NBS1 gene knockouts were lethal… more
Date: April 15, 2002
Creator: Kurimasa, Akihiro; Burma, Sandeep; Henrie, Melinda; Ouyang, Honghai; Osaki, Mitsuhiko; Ito, Hisao et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Clinical Results of Stereotactic Heavy-Charged-Particle Radiosurgery for Intracranial Angiographically Occult Vascular Malformations

Description: Angiographically occult vascular malformations (AOVMs) of the brain have been recognized for many years to cause neurologic morbidity and mortality. They generally become symptomatic due to intracranial hemorrhage, focal mass effect, seizures or headaches. The true incidence of AOVMs is unknown, but autopsy studies suggest that they are more common than high-flow angiographically demonstrable arteriovenous malformations (AVMs). We have developed stereotactic heavy-charged-particle Bragg peak ra… more
Date: December 1, 1989
Creator: Levy, R. P.; Fabrikant, J. I.; Phillips, M. H.; Frankel, K. A.; Steinberg, G. K.; Marks, M. P. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Follicular Growth and Atresia in the Mouse

Description: Follicles were classified on the basis of number of layers of follicle cells, presence and degree of development of the zona pellucida, and presence of an antrum. Formation of an antrum in follicles with less than 7-8 cell layers and/or presence of necrotic cells was considered indicative of degeneration. When classified in this manner, the data suggest that follicles and their contained oocytes are committed to either normal development or atresia by the time a third layer of granulosa cells i… more
Date: January 1, 1978
Creator: Oakberg, E. F.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Inhalation developmental toxicology studies: Teratology study of n-hexane in mice: Final report

Description: Gestational exposure to n-hexane resulted in an increase in the number of resorbed fetuses for exposure groups relative to the control group; however, the increases were not directly correlated to exposure concentration. The differences were statistically significant for the 200-ppM with respect to total intrauterine death (early plus late resorptions), and with respect to late resorptions for the 5000-ppM group. A small, but statistically significant, reduction in female (but not male) fetal b… more
Date: May 1, 1988
Creator: Mast, T. J.; Decker, J. R.; Stoney, K. H.; Westerberg, R. B.; Evanoff, J. J.; Rommereim, R. L. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The spatial evaluation of neighborhood clusters of birth defects

Description: Spatial statistics have recently been applied in epidemiology to evaluate clusters of cancer and birth defects. Their use requires a comparison population, drawn from the population at risk for disease, that may not always be readily available. In this dissertation the plausibility of using data on all birth defects, available from birth defects registries, as a surrogate for the spatial distribution of all live births in the analysis of clusters is assessed. Three spatial statistics that have … more
Date: April 16, 1990
Creator: Frisch, J. D.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Development and application of resistive pulse spectroscopy: studies on the size, form and deformability of red blood cells

Description: The following studies were conducted using the resistive pulse spectroscopy (RPS) technique: cumulative spectra and individual pulse forms for rigid latex polymer spheres; acquisition and analysis of RPS spectral data by means of special computer program; interaction of red blood cells with glutaraldehyde; membrane properties of erythrocytes undergoing abrupt osmotic hemolysis; reversible effects of the binding of chlorpromazine HCl at the red cell membrane surface; effects of high cholesterol … more
Date: January 1979
Creator: Yee, J. P.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Cancer and birth defects surveillance system for communities around the Savannah River Site

Description: This technical report presents the age-adjusted total, and race and sex specific geographic patterns of cancer mortality for South Carolina (SC) counties utilizing the 1953--1987 average annual age-adjusted mortality rates (AAMRs). The mortality information was obtained from the State Cancer Control Map and Data Program produced by the National Cancer Institute , Centers for Disease Control and the American Cancer Society. The AAMRs for selected primary sites are classified as significantly dif… more
Date: May 1, 1993
Creator: Dunbar, J.B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Clinical-radiological evaluation of sequelae of stereotactic radiosurgery for intracranial arteriovenous malformations

Description: Stereotactic heavy-charged-particle Bragg peak radiosurgery has been used to treat 322 patients with surgically-inaccessible intracranial vascular malformations. (The clinical results of this method for the treatment of angiographically demonstrable arteriovenous malformations (AVMs) and angiographically occult vascular malformations (AOVMs) of the brain are described in separate reports of this symposium). The great majority of patients have had an uneventful post-treatment course with satisfa… more
Date: December 1, 1989
Creator: Levy, R. P.; Fabrikant, J. I.; Frankel, K. A.; Phillips, M. H.; Steinberg, G. K.; Marks, M. P. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Radiation-induced micrencephaly in guinea pigs

Description: The effect of x rays on brain weight of guinea pig pups at birth was studied for 21-day old embroys exposed in utero to doses of 75 and 100 mGy. When compared to controls and when corrected for body weight, gestation time, litter size, sex, and examiner differences the brains of irradiated pups weighed approximately 46 mg less than those of controls (p<0.001) for the 75-mGy group and about 55 mg less for the 100-mGy group. Brains of females weighed 51 mg less than those of males of the same bod… more
Date: January 1, 1992
Creator: Wagner, L.K.; Johnston, D.A. & Felleman, D.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Stereotactic helium-ion radiosurgery for the treatment of intracranial arteriovenous malformations

Description: One of the more challenging problems of vascular neurosurgery is the management of surgically-inaccessible arteriovenous malformations (AVMs) of the brain. At Lawrence Berkeley Laboratory, we have developed the method of stereotactic heavy-charged-particle (helium-ion) Bragg peak radiosurgery for treatment of inoperable intracranial AVMs in over 300 patients since 1980 (Fabrikant et al. 1989, Fabrikant et al. 1985, Levy et al. 1989). This report describes patient selection, treatment method, cl… more
Date: December 1, 1989
Creator: Fabrikant, Jacob I.; Levy, R. P.; Frankel, K. A.; Phillips, M. H.; Lyman, J. T.; Chuang, F. Y. S. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Inhalation developmental toxicology studies: Teratology study of tetrahydrofuran in mice and rats: Final report

Description: Tetrahydrofuran (THF), a four-carbon cyclic ether, is widely used as an industrial solvent. Although it has been used in large quantities for many years, few long-term toxicology studies, and no reproductive or developmental studies, have been conducted on THF. This study addresses the potential for THF to cause developmental toxicity in rodents by exposing Sprague-Dawley rats and Swiss (CD-1) mice to 0, 600, 1800, or 5000 ppm tetrahydrofuran (THF) vapors, 6 h/day, 7 dy/wk. Each treatment group… more
Date: August 1, 1988
Creator: Mast, T. J.; Evanoff, J. J.; Stoney, K. H.; Westerberg, R. B.; Rommereim, R. L. & Weigel, R. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Effects of weightlessness, gravity compensation and radiation on the flour beetle, Tribolium confusum

Description: Tribolium confusum, the flour beetle; was chosen as a test organism for determination of possible synergistic effects of radiation and space environment in the inertial flight of Biosatellite-II. The organism subjected to weightlessness and radiation during the flight exhibited greater than expected wing abnormalities. However, a postflight vibration control experiment produced anomalous results, and some doubt remained with respect to assigning weightlessness as the sole cause of the increased… more
Date: October 1, 1975
Creator: Yang, C. H.; Silver, I. L. & Tobias, C. A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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