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ETOPOSIDE INDUCES CHROMOSOMAL ABNORMALITIES IN SPERMATOCYTES AND SPERMATOGONIAL STEM CELLS

Description: Etoposide (ET) is a chemotherapeutic agent widely used in the treatment of leukemia, lymphomas and many solid tumors, such as testicular and ovarian cancers, that affect patients in their reproductive years. The purpose of the study was to use sperm FISH analyses to characterize the long-term effects of ET on male germ cells. We used a mouse model to characterize the induction of chromosomal aberrations (partial duplications and deletions) and whole chromosomal aneuploidies in sperm of mice tre… more
Date: July 15, 2005
Creator: Marchetti, F; Pearson, F S; Bishop, J B & Wyrobek, A J
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

An analysis of uranium dispersal and health effects using a Gulf War case study.

Description: The study described in this report used mathematical modeling to estimate health risks from exposure to depleted uranium (DU) during the 1991 Gulf War for both U.S. troops and nearby Iraqi civilians. The analysis found that the risks of DU-induced leukemia or birth defects are far too small to result in an observable increase in these health effects among exposed veterans or Iraqi civilians. Only a few veterans in vehicles accidentally struck by U.S. DU munitions are predicted to have inhaled s… more
Date: July 1, 2005
Creator: Marshall, Albert Christian
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
captions transcript

[News Clip: Transplant]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story. This story aired at 6 P.M.
Date: November 30, 1990
Duration: 1 minute 38 seconds
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Item Type: Refine your search to only Video
Partner: UNT Libraries Special Collections
open access

Review of dosimetry for the atomic bomb survivors

Description: This paper summarizes and discusses results of some 1980-1981 studies of neutron and ..gamma..-ray exposure to the atomic bomb survivors by W.E. Loewe and E. Mendelsohn of the Lawrence Livermore National Laboratory, D.C. Kaul and W.H. Scott of Science Applications, Inc., and J.V. Pace of the Oak Ridge National Laboratory. Some other special studies which are now underway to complete the review will also be discussed. The expert assistance of others in these special studies is being supported in… more
Date: January 1, 1981
Creator: Kerr, G. D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Molecular and somatic-cell genetic analysis of metal-resistance mechanisms in mammalian cells

Description: Combined molecular genetic analyses and somatic cell systems were utilized to delineate factors involved in metal metabolism. Somatic cells derived by selection procedures using toxic heavy metals were used to define primary factors involved in acquisition of metal resistance. Such cell variants permitted isolation of the specific genes involved in conferring heavy metal binding proteins, the metallothioneins. (MT). These isolated genes provided the molecular probes to dissect the multiple leve… more
Date: January 1, 1983
Creator: Enger, M. D.; Hildebrand, C. E.; Walters, R. A.; Seagrave, J. C.; Barham, S. S. & Hoagland, H. C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Bovine lymphocytic leukemia: studies of etiology, pathogenesis and mode of transmission. Progress report No. 17, July 1976--October 1977

Description: The primary objective of the proposed research will be elucidation of the etiology and pathogenesis of bovine leukemia. We have consistently demonstrated C-type particles in mitogen stimulated lymphocyte cultures from leukemic cows and cows with a persistent lymphocytosis. These particles have been concentrated and partially purified by continuous flow, density gradient, ultracentrifugation. Newborn calves and late stage bovine fetuses have been inoculated with these concentrated cell free prep… more
Date: July 22, 1977
Creator: Sorensen, D. K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Bovine lymphocytic leukemia: studies of etiology, pathogenesis and mode of transmission. Progress report No. 18, June 1975--June 1978

Description: The primary objective of this research is to elucidate the cause(s) and early pathogenesis of the adult form of lymphosarcoma in cattle. Consequently, a major portion of our research is centered around experimental transmission of this disease. Bovine leukemia is believed to be caused by an oncogenic RNA virus designated bovine leukemia virus (BLV). We have consistently demonstrated the presence of BLV particles in leukemic cattle and cattle with a persistent lymphocytosis, but never in normal … more
Date: July 1, 1978
Creator: Sorensen, D.K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Bovine lymphocytic leukemia: studies of etiology, pathogenesis, and mode of transmission. Progress report No. 19, June 1978-June 1979

Description: Bovine leukemia is believed to be caused by an oncogenic RNA virus designated bovine leukemia virus (BLV). The presence of BLV particles in lymphocyte cultures from leukemic cattle and cattle with a persistent lymphocytosis has been consistentily demonstrated. Concentrated, cell free, BLV preparations were used to inoculate 12 late stage bovine fetuses (in utero) and two newborn calves. Current studies involve extensive monitoring of these inoculated animals to detect precancerous changes and o… more
Date: July 1, 1979
Creator: Sorensen, D.K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Clinical manifestations of bovine leukosis

Description: The diagnosis of animals infected with BLV can be accurately identified with the available serologic tests. Diagnosis of animals in the incipient stage of leukosis is extremely difficult and can only be diagnosed by a positive tissue biopsy. Animals with frank tumor involvement can be suspected and diagnosed on a tentative clinical basis on the signs reported. Positive diagnosis must be made on the basis of a biopsy of the tumor or in some cases on a hemotological examination.
Date: January 1, 1979
Creator: Sorensen, D.K.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Bovine lymphocytic leukemia: studies of etiology, pathogenesis, and mode of transmission. Progress report No. 16, July 1975--July 1976

Description: We have consistently demonstrated viral like particles in mitogen stimulated lymphocyte cultures from leukemic cows and cows with a persistent lymphocytosis. Our electron microscopic studies of these particles have shown them to be similar to the known oncogenic RNA viruses in size, plasma membrane budding, and in their C-type morphology. We have concentrated these bovine C-type particles approximately 1,000 fold by continuous flow ultracentrifugation. Our investigations employing these concent… more
Date: April 30, 1976
Creator: Sorensen, D. K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Off-Site Radiation Exposure Review Project: Phase 2 soils program

Description: To help estimate population doses of radiation from fallout originating at the Nevada Test Site, soil samples were collected throughout the western United States. Each sample was prepared by drying and ball-milling, then analyzed by gamma-spectrometry to determine the amount of {sup 137}Cs it contained. Most samples were also analyzed by chemical separation and alpha-spectrometry to determine {sup 239 + 240}Pu and by isotope mass spectroscopy to determine the ratios of {sup 240}Pu to {sup 239}P… more
Date: December 1, 1989
Creator: McArthur, R.D. & Miller, F.L. Jr.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Blood cancer prediction using leukemia microarray gene data and hybrid logistic vector trees model

Description: Article is a study proposing an approach for blood cancer disease prediction using the supervised machine learning approach to perform blood cancer prediction with high accuracy using microarray gene data.
Date: January 19, 2022
Creator: Rupapara, Vaibhav; Rustam, Furqan; Aljedaani, Wajdi; Shahzad, Hina Fatima; Lee, Ernesto & Ashraf, Imran
Item Type: Refine your search to only Article
Partner: UNT College of Engineering
captions transcript

[News Clip: Blood]

Description: Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about a blood drive at Irving's First Methodist Church. The blood is needed for leukemia research.
Date: January 27, 1958
Duration: 1 minute 48 seconds
Creator: WBAP-TV (Television station : Fort Worth, Tex.)
Item Type: Refine your search to only Video
Partner: UNT Libraries Special Collections
open access

Radiation Carcinogenesis. Progress Report IV, 15 March 1976--15 May 1977. [Abscopal Effects of Radiation on Parabiant Rats]

Description: The series of parabiont and irradiated rats has been completed, the lesions diagnosed and the data pertinent to tumors computerized and partly analyzed. The same series yielded 74 percent incidence of cataract in the irradiated partner following a whole-body dose of 1000 R with 0.2 percent in the shielded partner and also in controls. There was no abscopal effect. Other structures of the eye beside the lens, particularly the retina, showed extensive radiation damage. Parabiosis increased the in… more
Date: January 1, 1977
Creator: Warren, Shields & Gates, Olive
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Radiation Carcinogenesis. Progress Report V, 16 May 1977--15 May 1978

Description: Experiments are underway on the cocarcinogenic effects of asbestos and carcinogenic hydrocarbons using rats and mice as test objects. None of the protocols of these experiments have as yet been completed. The study of tumorigenesis in irradiated parabiont rats has been completed. Study of the benign tumors indicates that radiation is an effective neoplastic stimulus for only a limited number of organs and tissues, chiefly ovary, adrenal, mammary tissue, islands of Langerhans, and liver. In gene… more
Date: January 1, 1978
Creator: Warren, Shields & Gates, Olive
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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