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in subjects: "Iodouracils"  
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Photon-activation therapy

Description: Photon Activation Therapy (PAT) is a technique in which radiation dose to tumor is enhanced via introduction of stable /sup 127/I in the form of iodinated deoxyuridine (IdUrd). Stimulation of cytotoxic effects from IdUrd is accomplished by activation with external (or implanted) radiation sources. Thus, accumulations of this nucleoside in actively competing cellpools do not preclude therapy in so far as such tissues can be excluded from the radiation field. Calculations show that 5% replacement… more
Date: January 1, 1982
Creator: Fairchild, R.G. & Bond, V.P.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Radiation enhancement with /sup 127/I-deoxyuridine

Description: A technique for radiation enhancement of photon radiotherapy is outlined. High LET radiations in the form of Auger electron distributions are generated by photoactivation of stable iodine incorporated as iodinated deoxyuridine (IdUrd). Of the several halogenated deoxyribonucleosides evaluated, IdUrd was found to be the only thymidine analog providing effective photoactivation. This mechanism is combined with radiation sensitization to produce an overall radiation enhancement. Calculations show … more
Date: June 1, 1982
Creator: Fairchild, R.G.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Potential radiosensitizing antiviral and anticancer pyrimidine nucleosides. Final report, June 1, 1974--May 31, 1978

Description: The synthesis of a variety of novel nucleosides as potential antiviral, antineoplastic, and radiation sensitizing agents was investigated. The most significant accomplishment of this period was the development of 5-Iodo-5'-amino-2',5'-dideoxyuridine (AIU, AIdUrd) which is the first compound to require unequivocally, for antiviral activity, a unique activation by an enzyme (thymidine kinase) encoded by the Herpes virus genome. This unusual requirement for activation prevents toxicity to uninfect… more
Date: September 1, 1978
Creator: Prusoff, W.H.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and samarium-145 as a brachytherapy source

Description: High grade astrocytomas have proven resistant to all conventional therapy. A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (IdUrd) and by stimulation of Auger electron cascades through absorption of low energy photons in iodine (Photon activation) is described. Clinical studies using IdUrd, {sup 192}Ir as a brachytherapy source, and external radiation have produced promising results. Substituting samarium-145 for {sup 192}… more
Date: January 1, 1989
Creator: Goodman, J. H.; Gahbauer, R. A.; Kanellitsas, C.; Clendenon, N. R. (Ohio State Univ., Columbus, OH (USA)); Laster, B. H. & Fairchild, R. G. (Brookhaven National Lab., Upton, NY (USA))
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Kinetic and biochemical studies on tumor growth. Final report, October 1, 1967--July 14, 1976. [X radiation, /sup 125/I tracer technique]

Description: The normal growth kinetics and the recovery kinetics following therapeutic perturbations with drugs and x-irradiation for the mouse duodenal crypt cells and the S102F and slow line tumor cells have been studied in depth, the rationale being that a detailed understanding of these phenomena would enhance our knowledge about tumor biology per se and also expand our appreciation of how normal and malignant tissues respond to and recover from therapeutic insults. Hopefully, such knowledge will event… more
Date: unknown
Creator: Dethlefsen, L. A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Potential radiosensitizing antiviral and anticancer pyrimidine nucleosides. Technical progress report, June 1, 1975--December 22, 1975. [UV radiation]

Description: A newly developed method of synthesis now affords the large scale production of 5'-amino analogs of a variety of nucleosides. This procedure has been used to synthesize the 5'-amino analog of 5-iodo-, 5-bromo-, 5-chloro-, 5-fluoro-, 5-trifluoromethyl-2',5'-dideoxyuridine. In addition to the previously established antiviral activity of 5-iodo-5'-amino-2',5'-dideoxyuridine (AIU), we have found 5-bromo- (ABrU) and 5-iodo-5'-amino-2',5'-dideoxycytidine (AIC) to be even more potent antiviral agents … more
Date: January 1, 1976
Creator: Prusoff, W. H.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Photochemistry and photobiology of DNA containing 5-iodouracil and 5-iodocytosine. [Escherichia coli, Bacillus subtilis]

Description: The quantum yields for the photolysis of iodinated derivatives of cytosine (leading to the loss of iodine) has been measured for 313 nm radiation and found to decrease from 0.024 for IodCMP down to 0.007 for both Poly(C) and DNA containing 5-IodCyt. In DNA, approximately 1 clean chain break and 1 alkali-labile bond were formed for every 10 iodines lost. Incorporation of iodinated cytosine or uracil into the DNA of Escherichia coli or Bacillus subtilis was shown to have a large effect on the bio… more
Date: January 1, 1978
Creator: Rahn, R.O.; Stafford, R.S. & Hadden, C.T.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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