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Radiation dose estimates for copper-64 citrate in man

Description: Tumor imaging agents suitable for use with positron emission tomographs are constantly sought. We have performed studies with animal-tumor-bearing models that have demonstrated the rapid uptake of copper-64. The radiation dose estimates for man indicate that the intravenous administration of 7.0 mCi would result in radiation doses to the kidney of 9.8 to 10.5 rads with other organs receiving substantially less radiation. 5 refs., 3 tabs.
Date: January 1, 1985
Creator: Crook, J.E.; Carlton, J.E.; Stabin, M. & Watson, E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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A high intensity positron beam at the Brookhaven reactor

Description: We describe a high intensity, low energy positron beam utilizing high specific activity /sup 64/Cu sources (870 Ci/g) produced in a reactor with high thermal neutron flux. Fast-to-slow moderation can be performed in a self moderation mode or with a transmission moderator. Slow positron rates up to 1.6 x 10/sup 8/ e/sup +//s with a half life of 12.8 h are calculated. Up to 1.0 x 10/sup 8/ e/sup +//s have been observed. New developments including a Ne moderator and an on-line isotope separation p… more
Date: January 1, 1987
Creator: Weber, M.; Lynn, K. G.; Roellig, L. O.; Mills, A. P., Jr. & Moodenbaugh, A. R.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Effect of physicochemical form on copper availability to aquatic organisms

Description: Copper concentration and speciation were determined in influent and effluent waters collected from eight power stations that used copper alloys in their cooling systems. Quantities of copper associated with particles, colloids, and organic and inorganic ligands differed with the site, season, and mode of operation of the station. Under normal operating conditions, the differences between influent and effluent waters were generally small, and most of the copper was in bound (complexed) species. … more
Date: November 1, 1983
Creator: Harrison, F.L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Oncogene mRNA Imaging with Radionuclide-PNA-Peptides

Description: New cancer gene hybridization probes to carry radionuclides were made. Noninvasive technetium-99m gamma imaging of CCND1 cancer gene activity in human breast cancer tumors in mice was demonstrated, followed by noninvasive technetium-99m imaging of MYC cancer gene activity. Noninvasive imaging of CCND1 cancer gene activity in human breast cancer tumors in mice was demonstrated with a positron-emitting copper-64 probe, followed by noninvasive positron imaging of IRS1 cancer gene activity.
Date: March 19, 2008
Creator: Wickstrom, Eric
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Solid neon moderated electrostatic or magnetic positron beam

Description: A high intensity variable energy positron beam has been constructed at Brookhaven National Laboratory (BNL). Positrons from a 97mCi {sup 22}Na source are moderated by a thin layer of solid neon. A magnetic guiding system delivered up to 5{times}10{sup 6}e{sup +}/sec to an experiment. Currently tests are under way to facilitate the operation with the magnetic guiding system or -- for other experimental sites -- with an electrostatic beam transport. The electrostatic lenses are fabricated from {m… more
Date: January 1, 1991
Creator: Weber, M.; Schwab, A.; Becker, D. & Lynn, K. G.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Estimates of Columbia River radionuclide concentrations: Data for Phase 1 dose calculations

Description: Pacific Northwest Laboratory is conducting the Hanford Environmental Dose Reconstruction Project to estimate the radiation doses people may have received from historical Hanford Site operations. Under the direction of an independent Technical Steering Panel, the project is being conducted in phases. The objective of the first phase is to assess the feasibility of the project-wide technical approach for acquiring data and developing models needed to calculate potential radiation doses. This repo… more
Date: May 1, 1991
Creator: Richmond, M. C. & Walters, W. H.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Phase 1 of the Hanford Environmental Dose Reconstruction Project

Description: This report summarizes the water pathway portion of the first phase of the Hanford Environmental Dose Reconstruction (HEDR) Project, conducted by Battelle staff at the Pacific Northwest Laboratory under the direction of an independent Technical Steering Panel. The HEDR Project is estimating radiation doses that could have been received by the public from the Department of Energy's Hanford Site, in southeastern Washington State. Phase 1 of the water-pathway dose reconstruction sought to det… more
Date: July 20, 1990
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Use of total beta counts to estimate GI tract dose rates

Description: It was the practice for several years to estimate the potential dose rate to the gastrointestinal from sanitary water sources by evaluating the results of radiochemical analysis of individual nuclides. The proposed method estimates the GI tract dose from Pasco and Richland domestic water from measurements of the total beta activity, and permits more frequent and more economical evaluation of a variable source of radiation exposure. Beginning with 1964 data, the GI tract dose rate for Richland a… more
Date: October 25, 1965
Creator: Hall, R.B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Potential new approaches for the development of brain imaging agents for single-photon applications

Description: This paper describes new strategies for the brain-specific delivery of radionuclides that can be used to evaluate regional cerebral perfusion by single photon imaging techniques. A description of several examples of interesting new strategies that have recently been reported is presented. A new approach at this institution for the brain-specific delivery of radioiodinated iodophenylalkyl-substituted dihyronicotinamide systems is described which shows good brain uptake and retention in prelimina… more
Date: January 1, 1984
Creator: Knapp, F. F. Jr. & Srivastava, P. C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Summary of the Savannah River Site Criticality Dosimetry Program

Description: The mission of the Savannah River Site (SRS) includes working with fissionable materials. A program is in place, therefore, to assess neutron and gamma doses to individuals in the event of a criticality accident at SRS. The program consists of a method to quickly screen for potentially exposed personnel, a method to provide early but preliminary dose estimates, and a nuclear accident dosimeter and assay procedure to enable final dose estimates.
Date: February 1, 1993
Creator: Crase, K. W.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Phase 1 summaries of radionuclide concentration data for vegetation, river water, drinking water, and fish. Hanford Environmental Dose Reconstruction Project

Description: The objective of the Hanford Environmental Dose Reconstruction (HEDR) Project is to estimate the radiation doses that individuals and populations could have received from nuclear operations at the Hanford Site since 1944. As part of the HEDR Project, the Environmental Monitoring Data Task (Task 05) staff assemble, evaluate, and summarize key historical measurements of radionuclide concentrations in the environment as a result of Hanford operations. The scope of work performed during Phase I inc… more
Date: June 1, 1993
Creator: Denham, D. H.; Dirkes, R. L.; Hanf, R. W.; Poston, T. M.; Thiede, M. E. & Woodruff, R. K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A high intensity slow positron facility for the Advanced Neutron Source

Description: A slow positron spectroscopy facility, based on {sup 64}Cu activation, has been designed for incorporation in the Advanced Neutron Source (ANS). The ANS is a reactor-based research center planned for construction at Oak Ridge, Tennessee, USA. Multiple sources of slow positron beams will be available. One-half mm diameter, copper-coated aluminum microspheres will be activated and transported to a positron spectroscopy building, where they will be dispersed over the surfaces of horizontal pans, 0… more
Date: July 1, 1994
Creator: Hulett, L. D. Jr. & Eberle, C. C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Preparation of radiopharmaceuticals labeled with metal radionuclides. Progress report, July 1, 1988--June 30, 1992

Description: We recently developed a useful zinc-62/copper-62 generator and are presently evaluating copper-62 radiopharmaceuticals for clinical studies. While developing these copper-62 radiopharmaceuticals, in collaboration with the University of Missouri Research Reactor, Columbia we have also explored copper-64 radiopharmaceuticals. The PET images we obtained with copper-64 tracers were of such high quality that we have developed and evaluated copper-64 labeled antibodies for PET imaging. The major rese… more
Date: June 1, 1992
Creator: Welch, M. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The fitting of radioactive decay data by covariance methods

Description: The fitting of radioactive decay data is examined when radiations from two or more processes are indistinguishable. The model is a nonlinear sum of exponentials which cannot be linearized by transformations. Simple and generalized least-squares procedures utilizing covariance matrices are applied. The validity of the midpoint approximation is demonstrated. Guidelines for acquiring adequate radioactive decay data are suggested. The relevance to activation cross section determination is discussed. more
Date: April 1, 1994
Creator: Smith, D. L. & Osadebe, F. A. N.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

An anion exchange-precipitation procedure for the determination of Na{sup 24} in reactor effluent water

Description: The isotope Na{sup 24} is one of the major short half-life constituents of reactor effluent water. It has a half-life of 15 hours and decays of emission of a 1.39 MeV maximum beta particle. Other radioisotopes present in reactor effluent water from which Na{sup 24} must be separated are Si{sup 31}, P{sup 32}, Mn{sup 56}, Cu{sup 64}, As{sup 76}, Sr{sup 91--92}, Ba{sup 139--140} and rare earths. This report describes a rapid and very simple method for the quantitative determination of Na{sup 24} … more
Date: August 10, 1955
Creator: Perkins, R. W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Biomedical Radioisotope Program. Progress report for quarter ending March 31, 1977

Description: Progress is reported for the applications of {sup 11}C, {sup 195m}Pt, and {sup 123m}Te. Of note in this report period is the presentation of images of rat adrenals with a {sup 123m}Te-labeled steriod and an investigation of steriod structural parameters which affect adrenal concentration. Two new {sup 195m}Pt-labeled compounds have been prepared for evaluation as chemotherapeutic agents.
Date: June 1, 1977
Creator: Poggenburg, J.K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Positron Scanner for Brain Tumors

Description: It was thought that if a multi-detector device could be developed, the scanning time would be greatly shortened, with such consequent advantages as being able to work with lower dose of radiation, to obtain serial determinations, and to work with shorter-lived isotopes.
Date: October 9, 1964
Creator: Robertson, J. S. & Bozzo, S. R.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Nuclear Reactions Induced by Pions and Protons

Description: Effects due to elementary particle-like collisions within nuclear matter have been observed in several nuclear reactions caused by pions and protons. Simple nuclear reactions of the form ZA(a,an)Z/sup A-1/ and Z/sup A/(a,ap)(Z-1)/ sup A-1/ have excitation functions that are sensitive to changes in the elementary-particle cross sections. The excitation function for the reaction C/ sup 12/( pi /sup -/, pi /sup -/n)C/sup 11/ is measure d from 53 to 1610 Mev by bombarding targets of plastic scintil… more
Date: November 27, 1962
Creator: Reeder, P. L.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries Government Documents Department
open access

Summary of the Savannah River Site Criticality Dosimetry Program

Description: The mission of the Savannah River Site (SRS) includes working with fissionable materials. A program is in place, therefore, to assess neutron and gamma doses to individuals in the event of a criticality accident at SRS. The program consists of a method to quickly screen for potentially exposed personnel, a method to provide early but preliminary dose estimates, and a nuclear accident dosimeter and assay procedure to enable final dose estimates.
Date: February 1, 1993
Creator: Crase, K.W.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Solid neon moderated electrostatic or magnetic positron beam

Description: A high intensity variable energy positron beam has been constructed at Brookhaven National Laboratory (BNL). Positrons from a 97mCi {sup 22}Na source are moderated by a thin layer of solid neon. A magnetic guiding system delivered up to 5{times}10{sup 6}e{sup +}/sec to an experiment. Currently tests are under way to facilitate the operation with the magnetic guiding system or -- for other experimental sites -- with an electrostatic beam transport. The electrostatic lenses are fabricated from {m… more
Date: December 31, 1991
Creator: Weber, M.; Schwab, A.; Becker, D. & Lynn, K. G.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Development of positron emitting radionuclides for imaging with improved positron detectors. [/sup 82/Rb, /sup 62/Zn, /sup 64/Cu, /sup 67/Ga]

Description: Recent advances in positron cameras and positron ring detectors for transverse section reconstruction have created renewed interest in positron emitting radionuclides. This paper reports on: generator-produced /sup 82/Rb; cyclotron-produced /sup 62/Zn; and reactor-produced /sup 64/Cu. Investigation of the /sup 82/Sr (25 d)--/sup 82/Rb (75 s) generator determined the elution characteristics for Bio-Rex 70, a weakly acidic carboxylic cation exchanger, using 2% NaCl as the eluent. The yield of /su… more
Date: October 1, 1976
Creator: Yano, Y.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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