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Research on human genetics in Iceland. Progress report

Description: Records of the Icelandic Population are being used to investigate the possible inheritance of disabilities and diseases as well as other characters and the effect of environment on man. The progress report of research covers the period 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized and linked t… more
Date: October 31, 1980
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Progress report on research on human genetics in Iceland

Description: Records of the Icelandic population are being used to investigate the possible inheritance of disabilities and diseases as well as other characteristics and the effect of environment on man. The progress report of research covers the period from 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized an… more
Date: October 31, 1980
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Harvard-MIT research program in short-lived radiopharmaceuticals

Description: This report presents research on radiopharmaceuticals. The following topics are discussed: antibody labeling with positron-emitting radionuclides; antibody modification for radioimmune imaging; labeling antibodies; evaluation of technetium acetlyacetonates as potential cerebral blood flow agents; and studies in technetium chemistry. (CBS)
Date: January 1, 1991
Creator: Adelstein, S.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Nuclear medicine program progress report for quarter ending December 31, 1991

Description: This report presents information on (1) a new improved synthesis of carrier-free rhenium-188-labeled Re(V) dimercaptosuccinic acid (DMSA) complex as a potential therapeutic agent for treatment of thyroid medullary carcinoma; and (2) the synthesis and evaluation of a series of iodine-125-labeled analogues of altanserine for imaging of serotonin receptors.
Date: April 1, 1992
Creator: Knapp, F. F., Jr.; Ambrose, K. R.; Callahan, A. P.; McPherson, D. W.; Mirzadeh, S.; Srivastava, P. C. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Uranium miner lung cancer study. Progress report, July 1, 1976--July 1, 1977

Description: This study was initiated in 1957 by the U.S. Public Health and many facets of this project are reaching final objectives. Many new studies have developed in the course of this study and will continue. The projects supported by the Energy Research and Development Administration are of utmost importance and consist of: collection of material from uranium miners known to have cancer of the lung into a tumor registry; manual on pulmonary cytology; regression study of sputum cytological findings in … more
Date: October 3, 1977
Creator: Saccomanno, G.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Respiratory tract carcinogenesis induced by radionuclides in the Syrian hamister

Description: Syrian hamsters were exposed to lung irradiation by various modalities that differed in degree of localization and the fraction of lung exposed. The animals were given alpha emitters under several exposure conditions: intratracheal (IT) instillation of /sup 210/Po and /sup 239/PuO/sub 2/-ZrO/sub 2/ microspheres; inhalation (INH) of /sup 238/ /sup 239/PuO/sub 2/-ZrO/sub 2/ particles; and/or intravenous (IV) injection of /sup 238/ /sup 239/PuO/sub 2/-ZrO/sub 2/ microspheres. Beta-emitting /sup 14… more
Date: January 1, 1979
Creator: Smith, D. M.; Thomas, R. G. & Anderson, E. C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Assessment of the radiological impact of the inactive uranium-mill tailings at Shiprock, New Mexico

Description: Uranium-mill tailings at an inactive site near Shiprock, New Mexico, contain an estimated 950 curies (Ci) of /sup 226/Ra together with its radioactive daughters. A radiological survey was conducted at this site in February 1976. Decontamination work and tailings stabilization performed at the site since that time have greatly changed conditions there and little effort was applied to quantification of potential health effects in comparison to the earlier consideration of the site at Salt Lake Ci… more
Date: December 1, 1979
Creator: Haywood, F. F.; Goldsmith, W. A.; Lantz, P. M.; Fox, W. F.; Shinpaugh, W. H. & Hubbard, H. M., Jr.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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A Phase 1 biodistribution study of p-boronophenylalanine

Description: The objectives of the Phase I BPA biodistribution study are as follows: Objective 1: To establish the safety of orally administered boronophenylalanine (BPA) as determined by monitoring of patient's vital signs and by clinical analysis of blood before and after BPA administration. Objective 2: To establish BPA pharmacokinetics by monitoring the rates of boron absorption into and clearance from the blood and the rate of urinary excretion of boron. Objective 3: To measure the amount of boron inco… more
Date: January 1, 1991
Creator: Coderre, J.A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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The Exosporium of B.cereus Contains a Binding Site for gC1qR/p33: Implication in Spore Attachment and/or Entry

Description: B. cereus, is a member of a genus of aerobic, gram-positive, spore-forming rod-like bacilli, which includes the deadly, B. anthracis. Preliminary experiments have shown that gC1qR binds to B.cereus spores that have been attached to microtiter plates. The present studies were therefore undertaken, to examine if cell surface gC1qR plays a role in B.cereus spore attachment and/or entry. Monolayers of human colon carcinoma (Caco-2) and lung cells were grown to confluency on 6 mm coverslips in shell… more
Date: January 1, 2008
Creator: Ghebrehiwet, Berhane; Tantral, Lee; Titmus, Matthew A.; Panessa-Warren, Barbara J.; Tortora, George T.; Wong, Stanislaus S. et al.
Item Type: Refine your search to only Book
Partner: UNT Libraries Government Documents Department
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Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

Description: Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can lead to decreased expression of BRCA1/2 in ovarian cancers. The mechanism of BRCA1/2 loss is a potential method of subclassifying high grade serous carcinomas. A consecutive series of 49 ovarian cancers was assessed for mutations status of BRCA1 and BRCA2, LOH at the BRCA1 and BRC… more
Date: May 2, 2008
Creator: Gilks, C. Blake; Press, Joshua Z.; De Luca, Alessandro; Boyd, Niki; Young, Sean; Troussard, Armelle et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Epigenetic reversion of breast carcinoma phenotype is accompanied by DNA sequestration

Description: The importance of microenvironment and context in regulation of tissue-specific genes is finally well established. DNA exposure to, or sequestration from, nucleases can be used to detect differences in higher order chromatin structure in intact cells without disturbing cellular or tissue architecture. To investigate the relationship between chromatin organization and tumor phenotype, we utilized an established 3-D assay where normal and malignant human breast cells can be easily distinguished b… more
Date: July 19, 2006
Creator: Sandal, Tone; Valyi-Nagy, Klara; Spencer, Virginia A.; Folberg,Robert; Bissell, Mina J. & Maniotis, Andrew J.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Regulation of in situ to invasive breast carcinoma transition

Description: The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a key event in breast tumor progression that is poorly understood. Comparative molecular analysis of tumor epithelial cells from in situ and invasive tumors has failed to identify consistent tumor stage-specific differences. However, the myoepithelial cell layer, present only in DCIS, is a key distinguishing and diagnostic feature. To determine the contribution of non-epithelial cells to tumor progression, we analyzed th… more
Date: May 7, 2008
Creator: Polyak, Kornelia; Hu, Min; Yao, Jun; Carroll, Danielle K.; Weremowicz, Stanislawa; Chen, Haiyan et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Regulation of In Situ to Invasive Breast Carcinoma Transition

Description: The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a key event in breast tumor progression that is poorly understood. Comparative molecular analysis of tumor epithelial cells from in situ and invasive tumors has failed to identify consistent tumor stage-specific differences. However, the myoepithelial cell layer, present only in DCIS, is a key distinguishing and diagnostic feature. To determine the contribution of non-epithelial cells to tumor progression, we analyzed th… more
Date: March 13, 2007
Creator: Hu, Min; Carroll, Danielle K.; Weremowicz, Stanislawa; Chen, Haiyan; Carrasco, Daniel; Richardson, Andrea et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Disruption of NBS1 gene leads to early embryonic lethality in homozygous null mice and induces specific cancer in heterozygous mice

Description: Nijmegen breakage syndrome (NBS) is a rare autosomal recessive chromosome instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition, with cellular features similar to that of ataxia telangiectasia (AT). NBS results from mutations in the mammalian gene Nbs1 that codes for a 95-kDa protein called nibrin, NBS1, or p95. To establish an animal model for NBS, we attempted to generate NBS1 knockout mice. However, NBS1 gene knockouts were lethal… more
Date: April 15, 2002
Creator: Kurimasa, Akihiro; Burma, Sandeep; Henrie, Melinda; Ouyang, Honghai; Osaki, Mitsuhiko; Ito, Hisao et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Ovarian carcinomas with genetic and epigenetic BRCA1 loss havedistinct molecular abnormalities

Description: Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can lead to decreased expression of BRCA1/2 in ovarian cancers. The mechanism of BRCA1/2 loss is a potential method of subclassifying high grade serous carcinomas. A consecutive series of 49 ovarian cancers was assessed for mutations status of BRCA1 and BRCA2, LOH at the BRCA1 and BRC… more
Date: July 23, 2007
Creator: Press, Joshua Z.; De Luca, Alessandro; Boyd, Niki; Young, Sean; Troussard, Armelle; Ridge, Yolanda et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Polo-like Kinase I is involved in Invasion through Extracellular Matrix

Description: Polo-like kinase 1, PLK1, has important functions in maintaining genome stability and is involved in regulation of mitosis. PLK1 is up regulated in many invasive carcinomas. We asked whether it may also play a role in acquisition of invasiveness, a crucial step in transition to malignancy. In a model of metaplastic basal-like breast carcinoma progression, we found that PLK1 expression is necessary but not sufficient to induce invasiveness through laminin-rich extracellular matrix. PLK1 mediates… more
Date: April 2, 2008
Creator: Bissell, Mina J; Rizki, Aylin; Mott, Joni D. & Bissell, Mina J
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Metastasis

Description: Distant metastasis of primary neoplasms is the main factor that limits the success of antineoplastic therapy. It can be regarded as an early or late event in the neoplastic process, and varies considerably with tumor type. The metastatic potential of a given tumor greatly influences prognosis. Tumor metastasis is not a single neoplastic event, rather, it involves several major steps: invasion of cells from the primary tumor into tissue, and penetration of blood and lymph vessels; release of tum… more
Date: October 1, 1991
Creator: Weller, R. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Health effects models for nuclear power plant accident consequence analysis: Modifications of models resulting from recent reports on health effects of ionizing radiation

Description: The Nuclear Regulatory Commission has sponsored several studies to identify and quantify the potential health effects of accidental releases of radionuclides from nuclear power plants. The most recent health effects models resulting from these efforts were published in two reports, NUREG/CR-4214, Rev. 1, Part 1 (1990) and Part 2 (1989). Several major health effects reports have been published recently that may impact the health effects models presented in these reports. This addendum to the Par… more
Date: August 1, 1991
Creator: Abrahamson, S.; Bender, M. A.; Boecker, B. B.; Scott, B. R. & Gilbert, E. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Respiratory tract tumors in Syrian hamsters following inhalation of Pu--ZrO/sub 2/ particles. [Comparison with incidence of lung tumors following intravenous injection of PuO/sub 2//ZrO/sub 2/ microspheres]

Description: Inhalation of radionuclide-bearing particles remains one of the most intensely pursued problems concerning the nuclear industry. This route of entry is generally accepted as the most probable, in case of human exposure, with ingestion being the other prominent source of concern. Many laboratory investigations, such as those reported here, continue to evaluate the possible consequences that may present health problems to the public domain. Syrian hamsters of both sexes received either inhaled (I… more
Date: January 1, 1979
Creator: Thomas, R. G. & Smith, D. M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Quantitative changes in sets of proteins as markers of biological response

Description: Exposure to either physical or chemical insults triggers a cascade of bio-chemical events within the target cell. This response requires adjustment within the protein population of the cell, some proteins becoming more abundant (those involved in the cellular response), others less abundant (those not required or counterproductive to the response). Thus, quantitative changes in the global protein population of an exposed biological system may well serve as an indicator of exposure, provided the… more
Date: January 1, 1990
Creator: Giometti, C.S.; Taylor, J.; Gemmell, M.A.; Tollaksen, S.L. (Argonne National Lab., IL (USA)); Lalwani, N.D. & Reddy, J.K. (Northwestern Univ., Chicago, IL (USA))
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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/sup 20/neon ion- and x-ray-induced mammary carcinogenesis in female rats

Description: One of the proposed uses of heavy ion irradiation is to image lesions of the human female breast. The rat model system was chosen to assess the carcinogenic potential of heavy ion irradiation in the belief that data obtained from rat studies would have a qualitatively predictive value for the human female. Accordingly, female rats were exposed to /sup 20/Ne ions at the BEVALAC and studied for the development of mammary neoplasia for 312 +- 2 days at Brookhaven along with rats exposed concurrent… more
Date: January 1, 1983
Creator: Shellabarger, C.J.; Baum, J.W.; Holtzman, S. & Stone, J.P.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Investigation on the Pulmonary Effects of Intermetallic Beryllium Compounds. Final Report, January 1, 1976-December 31, 1978

Description: The pulmonary response to the exposure to tantalum and niobium beryllide, and a copper beryllium alloy was investigated. The findings were compared to beryllium metal as positive control. 2.5 or 0.5 mg as beryllium were given to rats by intratracheal intubation. At 30, 60, and 90 days after exposure the response was similar with each material. There was inflammatory infiltrate by lymphocytes, macrophage accumulation, and beginning fibrosis of the terminal bronchioles. Epithelial hyperplasia occ… more
Date: unknown
Creator: Stemmer, K. L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Lung tumor induction in mice: neutron RBE at low doses. [0-50 rad range]

Description: Experimental studies have demonstrated that neutrons are more tumorigenic on a dose for dose basis than are gamma rays. However, recent studies examining dose-response relationships and dose rate or fractionation effects have served to emphasize inadequacies in our understanding of neutron carcinogenesis. These studies have demonstrated that the dose-response curves bend over at relatively low doses. This results in a dose response curve which has a convex upward form over the 20 to 240 rad dos… more
Date: January 1, 1982
Creator: Ullrich, R.L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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