14 Matching Results

Search Results

Advanced search parameters have been applied.
in subjects: "Anticoagulants"  
Results: 1 - 14
open access

Photochemistry of psoralen-DNA adducts, biological effects of psoralen-DNA adducts, applications of psoralen-DNA photochemistry

Description: This thesis consists of three main parts and totally eight chapters. In Part I, The author will present studies on the photochemistry of psoralen-DNA adducts, specifically, the wavelength dependencies for the photoreversals of thymidine-HMT (4'-hydroxymethyl-4, 5', 8-trimenthylpsoralen) monoadducts and diadduct and the same adducts incorporated in DNA helices and the wavelength dependecies for the photocrossslinking of thymidine-HMT monoadducts in double-stranded helices. In Part II, The author… more
Date: March 1, 1988
Creator: Shi, Yun-bo
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Radiation carcinogenesis: radioprotectors and photosensitizers

Description: This paper outlines 1) some of the salient features of radiation carcinogenesis that are pertinent to the questions of how the carcinogenic effects might be influenced, 2) the effects of radioprotectors on ionizing radiation-induced cancer, and 3) the effect of photosensitizers on UVR-induced skin cancer.
Date: January 1, 1982
Creator: Fry, R.J.M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Net biosynthesis of Antithrombin III by the isolated rat liver perfused for 12--24 hours. Compared with rat fibrinogen and. cap alpha. -2 (acute phase) globulin, Antithrombin III is not an acute phase protein

Description: Antithrombin III- heparin cofactor has been isolated from normal rat plasma, purified to homogeniety on acrylamide gel electrophoresis and used to prepare a monospecific antiserum in rabbits. Measurements of rat AT-III were made by a single radial immunodiffusion assay. Net synthesis of AT-III was investigated during 12 or 24 hour perfusions of the isolated rat liver. In perfusions performed under basal conditions cumulative synthesis of AT-III was observed to occur at a rate sufficient to repl… more
Date: January 1, 1978
Creator: Owens, M.R. & Miller, L.L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Possibilities and problems in uv radiation carcinogenesis experiments

Description: Experiments were designed to solve problems in dose-response relationships in uv-induced carcinogenesis. Two strains of hairless mice were exposed to 300 to 400 nm, 320 to 400 nm, and 365 nm wavelength emissions following exposure to 8-methoxy-psoralen; various fractionation regimes were used. Results showed that the number of psoralen-DNA crosslinks per cell increased linearly with dose. The importance of wavelength in the initiation and the expression of tumors is emphasized. (HLW)
Date: January 1, 1978
Creator: Fry, R.J.M.; Ley, R.D. & Grube, D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Chemical Biodynamics Division. Annual report 1979

Description: The Chemical Biodynamics Division of LBL continues to conduct basic research on the dynamics of living cells and on the interaction of radiant energy with organic matter. Many aspects of this basic research are related to problems of environmental and health effects of fossil fuel combustion, solar energy conversion and chemical/ viral carcinogenesis.
Date: August 1, 1980
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Labeling cellular elements of blood with Technetium-99m

Description: The purpose of this proposal is to develop new technique of labeling platelets and white cells with Tc-99m radionuclide. The conditions of labeling canine platelets and white cells with the lipid-soluble Tc-99m HMPAO have been optimized. The function of labeled platelets were evaluated by the determination of platelet survival time and recovery and these values were compared with that of In-111 tropolone labeled platelets. We developed the bilateral femoral catheterization model for the evaluat… more
Date: August 1, 1990
Creator: Dewanjee, M.K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Cell-cycle-related biosynthesis. [Sarkosyl, neocarzinostatin, adriamycin]

Description: The state of chromatin during the cell cycle was examined using synchronized cultures of CHO hamster cells. Results support Mazia's dynamic chromosome cycle model and indicate that DNA-interactive chemotherapeutic agents elicit different types of kinetic responses in treated cells, suggesting a degree of specificity of interaction between various alkylating and intercalating agents and the genome. Effects of sarkosyl crystals, heparin, and chemotherapeutic agents, neocarzinostatin and adriamyci… more
Date: January 1, 1976
Creator: Tobey, R. A. & Hildebrand, C. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Genes and gene expression: Localization, damage and control -- A multi-level and interdisciplinary study

Description: This progress report describes gains made in three projects entitled (1) 3-Dimensional nuclear topography of genes and chromosomes in interphase nuclei, (2) Sequence specific identification and perturbation of the genomic DNA in living cells by nonionic oligonucleotide analogs (Matagen), and Resolution and isolation of specific DNA restriction fragments.(DT)
Date: August 1, 1992
Creator: Ts'o, P.O.P.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Comparison of surface modifications of poly(ether urethanes) by chemical infusion and graft polymerization

Description: Our approach to surface modification uses the chemical infusion process to introduce materials into the outermost layer of the polymeric material, thereby altering the surface without changing the bulk properties of the polymer. The infused materials may slowly diffuse out of the infusion layer if they are volatile or highly mobile. However, if polymeric infusant materials are employed, they may become chain entangled with the host polymer and result in a permanently modified surface. A second … more
Date: January 1, 1988
Creator: Wrobleski, D.A.; Cash, D.L. & Hermes, R.E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Photosensitization in biological systems

Description: Our symposium examines the current status of our knowledge of the photosensitized reactions of nucleic acids and proteins. Significant advances have been made in this area of photobiology since the last international Congress. The first paper will explore the role of molecular oxygen in photosensitized reactions of proteins and nucleic acids. The last three papers are concerned primarily with photosensitized reactions of nucleic acids and their components in which the sensitizer is consumed by … more
Date: January 1, 1976
Creator: Spikes, J. D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Investigation of Molecular Mechanisms in Photodynamic Action and Radiobiology with Nanosecond Flash Photolysis and Pulse Radiolysis. Progress report, October 1, 1980-September 30, 1981

Description: Laser flash photolysis experiments have led to a new mechanism for the ultraviolet photolysis of aqueous tryptophan (Trp), indole (Ind) and certain indole derivatives. Excitation at 265 nm leads to photoionization via a pre-fluorescent state with thermal activation. A new formula is proposed for predicting enzyme inactivation quantum yields. The predictions are in good agreement with measurements on six important enzymes at 254 nm and 280 nm. Kinetics models have been developed and tested for i… more
Date: June 1, 1981
Creator: Grossweiner, Leonard I.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Investigation of Molecular Mechanisms in Photodynamic Action and Radiobiology with Nanosecond Flash Photolysis and Pulse Radiolysis. Progress Report, July 1, 1975--June 30, 1976

Description: Flash photolysis studies have shown that exposed tyrosyl or tryptophyl residues of enzymes are photoionized at approximately the same quantum efficiency as the aqueous amino acids. Comparisons with permanent damage indicate that this primary process contributes to inactivation when a photolyzed aromatic residue is essential or is located adjacent to a catalytic, non-chromoporic residue. Studies on sensitization by the phototherapeutic drug, 8-methoxypsoralen (8-MOP), show the triplet state can … more
Date: March 1, 1976
Creator: Grossweiner, Leonard I.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
Back to Top of Screen