51 Matching Results

Search Results

Advanced search parameters have been applied.
in subjects: "550900 -- Pathology"  
Results: 1 - 24 next
open access

Tumors of the skin and soft tissues

Description: The majority of the body surface is covered by the skin. Many internal disorders are reflected in the condition of the skin. One of the major functions of the skin is protection of the other organ systems from a variety of environmental insults. In this role, the skin itself is exposed to factors that can ultimately cause chronic diseases and cancer. Since it is relatively easy to recognize skin abnormalities, most skin cancers are brought to professional attention sooner than other types of ca… more
Date: October 1, 1991
Creator: Weller, R. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Using mathematical models to understand the AIDS spidemic. [None]

Description: The most urgent public health problem today is to devise effective strategies to minimize the destruction caused by the AIDS epidemic. This complex problem will involve medical advances and new public health and education initiatives. Mathematical models based on the underlying transmission mechanisms of the AIDS virus can help the medical/scientific community understand and anticipate its spread in different populations and evaluate the potential effectiveness of different approaches for bring… more
Date: January 1, 1987
Creator: Hyman, J.M. & Stanley, E.A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Augmented Fish Health Monitoring; Volume 1. Completion Report.

Description: The Bonneville Power Administration (BPA) initiated the Augmented Fish Health Monitoring project in 1986. This project was a five year interagency project involving fish rearing agencies in the Columbia Basin. Historically, all agencies involved with fish health in the Columbia Basin were conducting various levels of fish health monitoring, pathogen screening and collection. The goals of this project were; to identify, develop and implement a standardized level of fish health methodologies, dev… more
Date: May 1, 1991
Creator: Michak, Patty
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

DNA damage and carcinogenesis

Description: Although cancer may arise as a result of many different types of molecular changes, there is little reason to doubt that changes to DNA are one of the more important ones in cancer initiation. Although DNA repair mechanisms seem able to eliminate a very large fraction of deleterious changes to DNA, we not only have little insight into the molecular mechanisms involved in such repair, but have a negligible amount of information to permit us to estimate the shape of dose response relations at low… more
Date: January 1, 1980
Creator: Stelow, R B
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Genetic influence on brain catecholamines: high brain norepinephrine in salt-sensitive rats

Description: Rats genetically sensitive to salt-induced hypertension evinced higher levels of plasma norepinephrine and epinephrine than rats genetically resistant to hypertension. The hypertension-sensitive rats showed higher hypothalamic norepinephrine and lower epinephrine than resistant rats. In response to a high salt diet, brain stem norepinephrine increased in sensitive rats while resistant rats exhibited a decrease on the same diet.
Date: January 1, 1980
Creator: Iwai, J; Friedman, R & Tassinari, L
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Radiation toxicology

Description: The extensive studies on both human and experimental animal populations have provided information that allows radiation protection standards to be set with greater confidence than for most if not all other carcinogenic agents. Furthermore, both international and national advisory bodies are continually updating the risk estimates and the standards as new information is available. However, it is clear that we need models that take into account the multistage nature of carcinogenesis. Studies in … more
Date: January 1, 1979
Creator: Fry, R.J.M.; Storer, J.B. & Ullrich, R.L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Effects of chemical carcinogens of hemopoiesis, immunopoiesis and viral oncogenesis. Technical progress report, December 1, 1977--September 30, 1978. [Mechanisms of potentiation of viral leukemogenesis by MMS, benzopyrene, and DMBA]

Description: During the past year we have concentrated on defining the circumstances under which methyl methanesulfonate (MMS), benzo(a) pyrene (BP), and 7,12-dimethylbenz(a)anthracene (DMBA) interact with Friend virus (FLV) to produce leukemia. The optimum scheduling for each and also the effective dose levels of the chemicals have been partially determined. There are at least three critical factors which govern whether or not a leukemogenic interaction can be shown between the chemical agents and the viru… more
Date: October 1, 1978
Creator: OKunewick, J.P.; Raikow, R.B. & Meredith, R.F.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Biological Manipulation of Migration Rate: The Use of Advanced Photoperiod to Accelerate Smoltification in Yearling Chinook Salmon, Annual Report 1989.

Description: Research was conducted to assess the feasibility of biologically manipulating physiological development and migratory behavior of yearling spring chinook salmon, Oncorhynchus tshawytscha. At Dworshak National Fish Hatchery, treatment groups were exposed to a variety of advanced photoperiod cycles preceding release to accelerate smolt development. Physiological development and migratory performance were described for all groups. The treatments included a 14-week exposure to a 3-month advanced ph… more
Date: January 1, 1991
Creator: Giorgi, Albert E.; Muir, William D. & Zaugg, Waldo S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Study on the induction of thyroid tumors in rats using x irradiation in conjunction with a goitrogen. [1 methyl--2 mercaptoimidazole (methimazole)]

Description: The influence of acute localized thyroid x irradiation and chronic goitrogen administration, separately or combined, on thyroid tumor formation in mature female rats was studied. In the first experiment, the radiation doses were 0, 80, 160, 320, or 640 rads, and the dosages of goitrogen were 0, 4, or 40 parts per million (ppM) of 1 methyl - 2 mercaptoimidazole (MMI). The incidence of rats with thyroid tumors in any treated group receiving 0 or 4 ppM MMI was not significantly greater than the in… more
Date: January 1, 1979
Creator: Mahler, P.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Effect of chemical carcinogens on hematopoietic stem cells: temporal correlation between methyl methane sulfonate induced depression of CFU-S and potentiation of Friend viral leukemogenesis in vivo. [Mice]

Description: Methyl methane sulfonate (MMS) was shown to reduce the number of transplantable pluripotent hematopoietic stem cells (CFU-S) in the mouse spleen. A mild depression in CFU-S numbers was seen as early as 1 hr after injection of the chemical carcinogen. Maximal depression was found to be at 5 hrs, followed by a recovery of up to 75% of normal levels by 24 hrs. Comparison of the data with earlier reslts which demonstrated a potentiating effect of MMS on viral leukemogenesis in vivo revealed a good … more
Date: May 1, 1979
Creator: Raikow, R. B.; OKunewick, J. P.; Meredith, R. F.; Brozovich, B. J. & Seeman, P. R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Test for detection of clustering over time. [Statistical study of spontaneous abortions in NYC]

Description: The use of the scan statistic in testing for clustering in time is discussed with particular reference to a reported clustering of trisomies in spontaneous abortions in New York City (spontaneous abortions have been used on occasion to monitor environmental health effects). The scan statistic is the maximum number of observed cases in an interval of preselected length, as the interval is allowed to scan, or slide along, the time frame of interest. A table of the lower tail of the distribution o… more
Date: March 1, 1979
Creator: Wallenstein, S
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Knowledge engineering software: A demonstration of a high end tool

Description: Many investigators wanting to apply knowledge-based systems (KBS) as consultants for cancer diagnosis have turned to tools running on personal computers. While some of these tools serve well for small tasks, they lack the power available with the high end KBS tools such as KEE (Knowledge Engineering Environment) and ART (Automated Reasoning Tool). These tools were originally developed on Lisp machines and have the full functionality of the Lisp language as well as many additional features. They… more
Date: January 1, 1987
Creator: Salzman, G.C.; Krall, R.B. & Marinuzzi, J.G.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Los Alamos Life Sciences Division's biomedical and environmental research programs. Progress report, January-December 1981. [Leading abstract]

Description: This report summarizes research and development activities of the Los Alamos Life Sciences Division's Biomedical and Environmental Research program for the calendar year 1981. Individual reports describing the current status of projects have been entered individually into the data base.
Date: October 1, 1982
Creator: Holland, L.M. & Stafford, C.G. (comps.)
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Evaluation of fish kills during November 1986 and July 1987 in upper East Fork Poplar Creek near the Y-12 Plant

Description: The Environmental Sciences Division (ESD) investigated two fish kills that occurred on November 21, 1986, and July 9, 1987, in upper East Fork Poplar Creek at the outfall of New Hope Pond (NHP) below the Oak Ridge Y-12 Plant. Investigative procedures included sampling of water at the inlet and outfall of NHP for water quality, examination of operating procedures at the Y-12 Plant and in the biomonitoring program that may have adversely affected the fish populations, review of results of concurr… more
Date: September 1, 1990
Creator: Ryon, M.G.; Loar, J.M.; Southworth, G.R.; Stewart, A.J.; Adams, S.M. & Kszos, L.A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

On the cells of origin of radiogenic thyroid cancer: New studies based on an old idea

Description: We have presented evidence that the functional thyroid follicles (follicular units, FU) which are formed in grafts of monodispersed rat thyroid cells, and hence the thyroid tumors which later develop in such grafts, are clonal in origin. Recent studies have been designed to investigate: whether cell number-dependent inhibition of promotion-progression is mediated by remote hormonal feed-back, local cell-cell interactions, or both; the cell population kinetics of the clonogen subpopulation durin… more
Date: January 1, 1990
Creator: Clifton, K.H.; Domann, F.E. & Groch, K.M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Cellular proliferation and regeneration following tissue damage. Progress report. [X radiation; rabbit lenses]

Description: Studies were conducted on the following research projects: effects of x radiation on rabbit lenses; DNA synthesis and mitosis in cultured lenses; serum dependency and actinomycin D sensitivity; changes in ultrastructure; injury-induced growth of vascular endothelium; corneal neovascularization following injury; and human cataractous lenses. (HLW)
Date: January 1, 1977
Creator: Harding, C.V.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Rapid microbial identification by circular intensity differential scattering

Description: Circular Intensity Differential Scattering (CIDS) is one of the few really new approaches to microbial identification to have come into existence in the past several decades. The CIDS spectra can be measured as a function of wavelength, scattering angle, and/or matrix element, and a number of matrix elements can be measured virtually simultaneously. This panoply of measurements potentially gives the method resolving power for microbial identification. Some representative data taken over the pas… more
Date: June 1, 1984
Creator: Gregg, C.T. & Salzman, G.C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Lipids: Part of the tangled web

Description: Analysis of LDL subclasses by non-denaturing gradient gel electrophoresis has led to the identification of a subclass pattern characterized by predominance of small LDL, designated LDL subclass pattern B. The prevalence of pattern B in the general population is approximately 25%, but varies as a function of age and gender, being relatively uncommon in children and in premenopausal women. The remainder of the population has a predominance of larger LDL (pattern A) or an intermediate pattern. Our… more
Date: August 1, 1992
Creator: Krauss, R. M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Augmented Fish Monitoring, 1988 Annual Report.

Description: Since 1986 Washington department of Fisheries (WDF) has participated in the Columbia Basin Augmented Fish Health Monitoring Project. This project provides a standardized level of fish health information from all Agencies rearing fish in the Columbia Basin. WDF has actively participated in this project, and completed its second year of fish health monitoring, data collection and pathogen inspection during 1988. This report will present data collected from January 1, 1988 to December 31, 1988 and… more
Date: July 1989
Creator: Michak, Patty
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Effects of rainfall acidification on plant pathogens

Description: Wind-blown rain, rain splash, and films of free moisture play important roles in the epidemiology of many plant diseases. The chemical nature of the aqueous microenvironment at the infection court is a potentially significant factor in the successful dissemination, establishment, and survival of plant pathogenic microorganisms. Acidic rainfall has a potential for influencing not only the pathogen, but also the host organism, and the host-pathogen complex. Although host-pathogen interactions add… more
Date: January 1, 1978
Creator: Shriner, D. S. & Cowling, E. B.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Pulmonary macrophages: Phenomena associated with the particle overload'' condition

Description: Numerous lines of evidence support the generalization that alveolar macrophage (AM)-mediated particle clearance, or the transport of particle-containing AM from the alveoli out of the lung via the mucociliary apparatus, is a prominent mechanism that determines the pulmonary retention characteristics of relatively insoluble particles. Studies have also shown that the alveolar deposition of excessive burdens of particles with even low intrinsic cytotoxicity can result in impairments of the AM-med… more
Date: January 1, 1993
Creator: Lehnert, B. E.; Sebring, R. J. (Los Alamos National Lab., NM (United States)) & Oberdoerster, G. (Rochester Univ., NY (United States))
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

A mathematical model of the spread of the AIDS virus

Description: A mathematical computer model of the spread of the AIDS epidemic in the US is being developed at Los Alamos National Laboratory. This model predicts the spreading of the HIV infection, and subsequent development of clinical AIDS in various population groups. These groups are chosen according to age, frequency and type of sexual contact, population density, and region of the country. Type of sexual contact includes not only the heterosexual, homosexual differentiation but also repeated contacts … more
Date: January 1, 1987
Creator: Hyman, J.M. & Stanley, E.A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
Back to Top of Screen