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in subjects: "550900"

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Investigation of independence in inter-animal tumor-type occurrences within the NTP rodent-bioassay database

Statistically significant elevation in tumor incidence at multiple histologically distinct sites is occasionally observed among rodent bioassays of chemically induced carcinogenesis. If such data are to be relied on (as they have, e.g., by the US EPA) for quantitative cancer potency assessment, their proper analysis requires a knowledge of the extent to which multiple tumor-type occurrences are independent or uncorrelated within individual bioassay animals. Although difficult to assess in a sta… more

Date: May 1, 1993

Creator: Bogen, K. T. & Seilkop, S.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Acyclonucleosides of 2-nitroimidazole and uses as diagnostic and therapeutic agents

An acyclonucleoside of nitroimidazole having the ability to specifically bind to tumor cells and useful for therapy, chemotherapy, imaging and radiosensitizing the tumor cells.

Date: December 31, 1990

Creator: Srivastava, Prem C. & Hasan, Ahmad

Item Type: Patent

Partner: UNT Libraries Government Documents Department

open access

ORNL `90

This overview of research conducted at ORNL in 1991 presents information on the subjects of biology, physics, and the environment. Specific topics include gene mutations in kidney disease, technology assessments in thermonuclear fusion, submarine hunting technology, ozone-safe refrigerants, optical data storage via surface enhanced raman spectroscopy, and waste mitigating microbes. (GHH)

Date: December 31, 1990

Creator: Anderson, T.; Barnes, D. & Jefferson, J.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

The significant human-animal bond: Pets with cancer

Veterinarians have responsibilities to both the animal and its owner. In the past several years there has been an increased awareness and concern about human-animal bonds. As a result, we have begun to appreciate the nature, strength, and significance of bonds that develop between humans and companion animals. It is typical for a pet to be perceived as and treated as a member of the family and as a result, animals provide special and beneficial relationships for many years. It is partly because… more

Date: March 1, 1994

Creator: Weller, R. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Diagnosis and management of endocrine gland neoplasmas. Revision 1

Functional and nonfunctional neoplasms of the endocrine glands constitute some of the more challenging diagnostic and therapeutic problems in veterinary cancer medicine. This discussion will focus on the clinical signs and syndromes associated with neoplasms of the thyroid, adrenal, and parathyroid glands, and pancreas in companion animals and will concentrate on the mechanisms producing the clinical signs, diagnosis, staging, therapy and prognosis.

Date: March 1, 1994

Creator: Weller, R. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Urogenital tumors

An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

Date: March 1, 1994

Creator: Weller, R. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Correlation of chromosome patterns in human leukemic cells with exposure to chemicals and/or radiation. Comprehensive progress report, July 1991--June 1994

This comprehensive progress report provides a synopsis of major research accomplishments during the years of 1991-1994, including the technical aspects of the project. The objectives and accomplishments are as follows: 1. Defining the chromosome segments associated with radiation and chemically-induced leukemogenesis (treatment-related acute myeloid leukemia, t-AML); A. Continued genetic analysis of chromosomes 5 and 7, B. Correlation of treatment with balanced and unbalanced translocations. 2.… more

Date: June 1, 1994

Creator: Rowley, J. D.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Evidence of T-cell abnormalities in immunodeficient wasted mice

No Description Available.

Date: December 31, 1991

Creator: Libertin, C. R.; Gavinski, S. & Woloschak, G. E.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Method for distinguishing normal and transformed cells using G1 kinase inhibitors

A G{sub 1} phase kinase inhibitor is applied in a low concentration to a population of normal and transformed mammalian cells. The concentration of G{sub 1} phase kinase inhibitor is selected to reversibly arrest normal mammalian cells in the G{sub 1} cell cycle without arresting growth of transformed cells. The transformed cells may then be selectively identified and/or cloned for research or diagnostic purposes. The transformed cells may also be selectively killed by therapeutic agents that d… more

Date: December 31, 1991

Creator: Crissman, H. A.; Gadbois, D. M.; Tobey, R. A. & Bradbury, E. M.

Item Type: Patent

Partner: UNT Libraries Government Documents Department

open access

Lipoprotein subclasses in genetic studies: The Berkeley Data Set

Data from the Berkeley Data Set was used to investigate familial correlations of HDL-subclasses. Analysis of the sibling intraclass correlation coefficient by HDL particle diameter showed that sibling HDL levels were significantly correlated for HDL{sub 2b}, HDL{sub 3a} and HDL{sub 3b} subclasses. The percentage of the offsprings` variance explained by their two parents. Our finding that parents and offspring-have the highest correlation for HDL{sub 2b} is consistent with published reports that… more

Date: October 1, 1992

Creator: Krauss, R. M.; Williams, P. T.; Blanche, P. J.; Cavanaugh, A.; Holl, L. G. & Austin, M. A.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Conceptual design of an 8 Tesla superconducting wiggler for a dedicated digital subtraction angiography source

One of the most important techniques used to diagnose heart disease is coronary angiography. Coronary angiography is only used when it is absolutely essential because of the risk of fatalities and other serious complications arising from the insertion of the catheter. The technique also exposes the patients to large amounts of x-rays. Research, begun at SSRL and continued on the X17 beam line at NSLS, demonstrated the feasibility of imaging human coronary arteries following venous injection of … more

Date: September 1, 1993

Creator: Blum, E. B.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

PCR detection of retinoblastoma gene deletions in radiation-induced mouse lung adenocarcinomas

From 1971 to 1986, Argonne National Laboratory conducted a series of large-scale studies of tumor incidence in 40,000 BCF{sub 1} mice irradiated with {sup 60}Co {gamma} rays or JANUS fission-spectrum neutrons; normal and tumor tissues from mice in these studies were preserved in paraffin blocks. A polymerase chain reaction (PCR) technique has been developed to detect deletions in the mouse retinoblastoma (mRb) gene in the paraffin-embedded tissues. Microtomed sections were used as the DNA sourc… more

Date: April 1, 1993

Creator: Churchill, M. E.; Gemmell, M. A. & Woloschak, G. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Dose-response relationships for female radium dial workers: A new look

The values of initial systemic intake and of skeletal dose for all of the U.S. radium cases have recently been revised. This revision was required following the demonstrations by Rundo and by Keane that humans who were exposed to radium as adults lost radium at a rate that depended on the quantity of radium originally deposited within their bodies. These new values have been used to define new dose-response relationships for both the bone sarcomas and the carcinomas arising in the paranasal sin… more

Date: May 1, 1994

Creator: Rowland, R. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Tumorigenesis in the U.S. radium luminizers: How unsafe was this occupation?

Dose-response data are presented from the U.S. female workers who were exposed to radium through the painting of luminous dials and who subsequently had their skeletal burdens measured by whole-body counting and radon breath analyses. Lognormal data analyses were done for radium-induced bone sarcomas and head carcinomas after the populations of the respective doses were first determined to be lognormally distributed. The calculated geometric mean and standard deviation for each dose population … more

Date: May 1, 1994

Creator: Thomas, R. G.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Paraneoplastic syndromes

Paraneoplastic syndromes (PNS) comprise a diverse group of disorders that are associated with cancer but unrelated to the size, location, metastases, or physiologic activities of the mature tissue of origin. They are remote effects of tumors that may appear as signs, symptoms, or syndromes which can mimic other disease conditions encountered in veterinary medicine. Recognition of PNS is valuable for several reasons: the observed abnormalities may represent tumor cell markers and facilitate earl… more

Date: March 1, 1994

Creator: Weller, R. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

DM-CSF stimulated proliferation of rat alveolar macrophages and the effects of differing particulate burden levels in alveolar macrophages on the proliferative response

Particles are gradually redistributed among the lung`s population of alveolar macrophages (AM) at times well after they were originally deposited in the lung. One mechanism that may underlie this ``particle redistribution phenomenon`` is the in situ replication of particle-containing AM and the allocation of particles from dividing AM to daughter cells. Little is known about how the abilities of AM to proliferate may be affected by the containment of particles; conceivably, AM proliferation may… more

Date: May 1, 1993

Creator: Pendergrass, D.; Valdez, Y. E. & Lehnert, B. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

SNODOG Glossary: Part 1, Introduction

The SNODOG Glossary is used by the DOE-supported life-span beagle studies to describe medical observations in a standardized format. It is an adaptation of the human medical glossary, SNOMED, which lists 107,165 terms. Each of the five laboratories, Argonne National Laboratory, the Inhalation Toxicology Research Institute, the Pacific Northwest Laboratory, the University of California at Davis, and the University of Utah, has selected an appropriate subset from the published SNOMED glossary and… more

Date: April 15, 1993

Creator: Watson, C. R.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Pulmonary macrophages: Phenomena associated with the particle ``overload`` condition

Numerous lines of evidence support the generalization that alveolar macrophage (AM)-mediated particle clearance, or the transport of particle-containing AM from the alveoli out of the lung via the mucociliary apparatus, is a prominent mechanism that determines the pulmonary retention characteristics of relatively insoluble particles. Studies have also shown that the alveolar deposition of excessive burdens of particles with even low intrinsic cytotoxicity can result in impairments of the AM-med… more

Date: May 1, 1993

Creator: Lehnert, B. E.; Sebring, R. J. & Oberdoerster, G.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Malignant melanoma slide review project: Patients from non-Kaiser hospitals in the San Francisco Bay Area. Final report

This project was initiated, in response to concerns that the observed excess of malignant melanoma among employees of Lawrence Livermore National Laboratory (LLNL) might reflect the incidence of disease diagnostically different than that observed in the general population. LLNL sponsored a slide review project, inviting leading dermatopathology experts to independently evaluate pathology slides from LLNL employees diagnosed with melanoma and those from a matched sample of Bay Area melanoma pati… more

Date: January 5, 1993

Creator: Reynolds, P.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

On the cells of origin of radiogenic thyroid cancer: New studies based on an old idea

We have presented evidence that the functional thyroid follicles (follicular units, FU) which are formed in grafts of monodispersed rat thyroid cells, and hence the thyroid tumors which later develop in such grafts, are clonal in origin. Recent studies have been designed to investigate: whether cell number-dependent inhibition of promotion-progression is mediated by remote hormonal feed-back, local cell-cell interactions, or both; the cell population kinetics of the clonogen subpopulation durin… more

Date: December 31, 1990

Creator: Clifton, K. H.; Domann, F. E. & Groch, K. M.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Malignant transformation of diploid human fibroblasts by transfection of oncogenes. Part 2, Progress report, July 1989--June 1992

This document consist of brief reports prepared by postdoctoral students supported by the project, each describing his accomplishments under the grant. Topics include (1) Malignant Transformation of MSU-1. 1 Cells by Gamma Radiation, (2) Correlation between Levels of ras Expression and Presence of Transformed Phenotypes Including Tumorigenicity, Using a Modulatable Promoter, (3) Relation between Specific rad Oncogene Expression, (4) Correlation of Genetic Changes in Fibroblastic Tumors with Mal… more

Date: December 31, 1992

Creator: McCormick, J. J.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Noninvasive identification of bladder cancer with sub-surface backscattered light

A non-invasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. Absorp… more

Date: February 1, 1994

Creator: Bigio, I. J.; Mourant, J. R.; Boyer, J.; Johnson, T.; Shimada, T. & Conn, R. L.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Lipids: Part of the tangled web

Analysis of LDL subclasses by non-denaturing gradient gel electrophoresis has led to the identification of a subclass pattern characterized by predominance of small LDL, designated LDL subclass pattern B. The prevalence of pattern B in the general population is approximately 25%, but varies as a function of age and gender, being relatively uncommon in children and in premenopausal women. The remainder of the population has a predominance of larger LDL (pattern A) or an intermediate pattern. Our… more

Date: August 1, 1992

Creator: Krauss, R. M.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Malignant transformation of human fibroblasts in vitro

Although carcinogens cause human tumors, human cells in culture have not been successfully transformed to malignancy by exposure to carcinogens. It is now recognized that malignant transformation involves multiple changes within a cell and, therefore, successive clonal selection of cells containing such changes must occur. One explanation for the failure to induce in vitro malignant transformation of human cells could be inability to recognize cells that have undergone intermediate changes so a… more

Date: December 31, 1991

Creator: McCormick, J. J. & Maher, V. M.

Item Type: Article

Partner: UNT Libraries Government Documents Department