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in creator/contributor: "Srivastava, S.C."  
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The antibody approach of labeling blood cells

Description: Although the science of blood cell labeling using monoclonal antibodies directed against specific cellular antigens is still in its early stages, considerable progress has recently been accomplished in this area. The monoclonal antibody approach offers the promise of greater selectivity and enhanced convenience since specific cell types can be labeled in vivo, thus eliminating the need for complex and damaging cell separation procedures. This article focuses on these developments with primary e… more
Date: January 1, 1991
Creator: Srivastava, S.C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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New cholescintigraphic agent: ruthenium-97-DISIDA

Description: These studies demonstrate the first application of Ru-97-DISIDA in human subjects. High quality images were obtained. Scintigraphic findings in patients with hepatobiliary disorders were consistent with the biodistribution data obtained in experinmental animals and with other imaging procedures and clinical findings. Administration of Ru-97-DISIDA I.V. and of a solid test meal labeled with Tc-99m-Sulfur Colloid allowed simulateneous detection and quantification of deodenogastric reflux and dete… more
Date: June 1, 1986
Creator: Zanzi, I.; Srivastava, S.C.; Meinken, G,E.; Robeson, W.; Mausner, L.F.; Fairchild, R.G. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Criteria for the selection of radionuclides for tumor radioimmunotherapy

Description: The potential of utilizing monoclonal antibodies as carriers of radionuclides for the selective destruction of tumors (radioimmunotherapy, RIT) has stimulated much research activity. From dosimetric and other considerations, the choice of radiolabel is an important factor that needs to be optimized for maximum effectiveness of RIT. This paper reviews and assesses a number of present and future radionuclides that are particularly suitable for RIT based on the various physical, chemical, and biol… more
Date: January 1, 1991
Creator: Srivastava, S.C.; Mausner, L.F. & Mease, R.C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Radiolabeled red blood cells: status, problems, and prospects

Description: Radionuclidic labels for red cells can be divided into two main categories - cohort or pulse labels, and random labels. The random labels are incorporated into circulating cells of all ages and the labeling process is usually carried out in vitro. The red cell labels in predominant use involve random labeling and employ technetium-99m, chromium-51, indium-111, and gallium-68, roughly in that order. The extent of usefulness depends on the properties of the label such as the half-life, decay mode… more
Date: January 1, 1983
Creator: Srivastava, S.C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Radiolabeled monoclonal antibodies for imaging and therapy: Potential, problems, and prospects: Scientific highlights

Description: This meeting focused on areas of research on radiolabeled monoclonal antibodies. Topics covered included the production, purification, and fragmentation of monoclonal antibodies and immunochemistry of hybridomas; the production and the chemistry of radionuclides; the radiohalogenation and radiometal labeling techniques; the in-vivo pharmacokinetics of radiolabeled antibodies; the considerations of immunoreactivity of radiolabeled preparations; the instrumentation and imaging techniques as appli… more
Date: January 1, 1986
Creator: Srivastava, S.C. & Buraggi, G.L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Recent developments in monoclonal antibody radiolabeling techniques

Description: Monoclonal antibodies (MAbs) have shown the potential to serve as selective carriers of radionuclides to specific in vivo antigens. Accordingly, there has been an intense surge of research activity in an effort to develop and evaluate MAb-based radiopharmaceuticals for tumor imaging (radioimmunoscintigraphy) and therapy (radioimmunotherapy), as well as for diagnosing nonmalignant diseases. A number of problems have recently been identified, related to the MAbs themselves and to radiolabeling te… more
Date: January 1, 1989
Creator: Srivastava, S.C. & Mease, R.C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Therapeutic radionuclides: Making the right choice

Description: Recently, there has been a resurgence of interest in nuclear medicine therapeutic procedures. Using unsealed sources for therapy is not a new concept; it has been around since the beginnings of nuclear medicine. Treatment of thyroid disorders with radioiodine is a classic example. The availability of radionuclides with suitable therapeutic properties for specific applications, as well as methods for their selective targeting to diseased tissue have, however, remained the main obstacles for ther… more
Date: August 1, 1996
Creator: Srivastava, S.C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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