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in creator/contributor: "Shiue, C. Y."  
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Positron-emitting radioligands for imaging neuroleptic receptors

Description: A series of /sup 18/F-labeled butyrophenones (benperidol, haloperidol, spiroperidol and N-methylspiroperidol) were evaluated in baboons and rats with respect to potential utility as radioligands for studying neuroleptic receptors in the living human brain by positron emission tomography. These compounds were administered to baboons, and the radioactivity distributions to the striatum, and to the cerebellum were determined by PET at times up to 8 hours after isotope injection. 4 refs. (DT)
Date: January 1, 1985
Creator: Arnett, C. D.; Fowler, J. S.; Wolf, A. P.; Shiue, C. Y. & Logan, J.
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Partner: UNT Libraries Government Documents Department
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Synthesis of (/sup 18/F)-5-fluorouridine (F-18-5-FUR) as a probe for measuring RNA synthesis and tumor growth rates in vivo

Description: A method for the rapid synthesis of high specific activity of (/sup 18/F)-5-fluorouridine is described. The /sup 20/Ne(d,..cap alpha..)/sup 18/F nuclear reaction is used to produce high specific activity, anhydrous (/sup 18/F)-F/sub 2/ at the Brookhaven National Laboratory 60'' cyclotron. Fluorination of 2',3',5'-tri-0-acetyluridine with (/sup 18/F)-F/sub 2/ in glacial acetic acid at room temperature followed by hydrolysis with sodium methoxide in methanol gives (/sup 18/F)-5-fluorouridine with… more
Date: January 1, 1979
Creator: Shiue, C. Y.; Fowler, J. S.; MacGregor, R. R. & Wolf, A. P.
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Partner: UNT Libraries Government Documents Department
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Design and evaluation of radiotracers for determination of regional cerebral blood flow with PET

Description: The tracer kinetics of 4-Fluoro(/sup 18/F)-, 4-Bromo(/sup 82/Br)- and 4-Iodo(/sup 125/I)-antipyrine and /sup 15/O-water were compared in a cat or baboon animal model. First-pass cerebral extraction and clearance with alterations in PaCO/sub 2/ were measured for whole brain. The Renkin/Crone model was used to evaluate brain capillary permeability-surface area product for 4-/sup 18/FAP in cats. Positron-emission-tomographic measurements required development of an instrument and technique for cont… more
Date: January 1, 1982
Creator: Lambrecht, R. M.; Duncan, C. C. & Shiue, C. Y.
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Partner: UNT Libraries Government Documents Department
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Determination of the lumped constant and the kinetic constants for deoxyglucose and fluorodeoxyglucose in man

Description: If both the time course of the arterial plasma radionuclide concentration and the brain tissue radionuclide concentrations are known, it is possible to calculate the kinetic constants (k/sub 1/*, k/sub 2/*, k/sub 3/*, k/sub 4/*) of the glucose analogue. In a series of male subjects, arterial blood samples were obtained at frequent intervals immediately following the bolus administration of /sup 18/F-FDG and then at less frequent intervals for up to 5 hours after the radionuclide administration.… more
Date: January 1, 1985
Creator: Greenberg, J. H.; Reivich, M.; Alavi, A.; Wolf, A.; Fowler, J.; Russell, J. et al.
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Partner: UNT Libraries Government Documents Department
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