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in creator/contributor: "Pinkel, D."  
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Molecular cytogenetics using fluorescence in situ hybridization

Description: Fluorescence in situ hybridization (FISH) with chromosome-specific probes enables several new areas of cytogenetic investigation by allowing visual determination of the presence and normality of specific genetic sequences in single metaphase or interphase cells. in this approach, termed molecular cytogenetics, the genetic loci to be analyzed are made microscopically visible in single cells using in situ hybridization with nucleic acid probes specific to these loci. To accomplish this, the DNA i… more
Date: December 7, 1990
Creator: Gray, J.W.; Kuo, Wen-Lin; Lucas, J.; Pinkel, D.; Weier, H-U. & Yu, Loh-Chung.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Cytometric analysis of mammalian sperm for induced morphologic and DNA content errors

Description: Some flow-cytometric and image analysis procedures under development for quantitative analysis of sperm morphology are reviewed. The results of flow-cytometric DNA-content measurements on sperm from radiation exposed mice are also summarized, the results related to the available cytological information, and their potential dosimetric sensitivity discussed. (ACR)
Date: June 27, 1983
Creator: Pinkel, D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Analytical cytology applied to detection of induced cytogenetic abnormalities

Description: Radiation-induced biological damage results in formation of a broad spectrum of cytogenetic changes such as translocations, dicentrics, ring chromosomes, and acentric fragments. A battery of analytical cytologic techniques are now emerging that promise to significantly improve the precision and ease with which these radiation induced cytogenetic changes can be quantified. This report summarizes techniques to facilitate analysis of the frequency of occurrence of structural and numerical aberrati… more
Date: August 6, 1987
Creator: Gray, J.W.; Lucas, J.; Straume, T. & Pinkel, D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Livermore flow cytometer

Description: A stable, easy to operate, flow cytometer was built for routine use by research personnel in a biology laboratory. A 5 watt argon-ion laser excites the fluorescent dyes in cells flowing through a quartz flow chamber. A f/0.95 TV camera lens collects the fluorescent and scattered light and directs it through color separation filters and a beam splitter onto two photomultiplier tubes. Two 3-axis positioners are used to align the focused laser beam and the flow chamber with the light collection op… more
Date: November 19, 1981
Creator: Peters, D.C.; Dean, P.N. & Pinkel, D.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

X-Ray Holography at Lawrence Livermore National Laboratory

Description: The x-ray holography program at the Lawrence Livermore National Laboratory has two principal goals: (1) the development of x-ray diffraction techniques for DNA sequence analysis and (2) the development of x-ray laser holography for structural analysis of intact biological cells and organelles. DNA sequence analysis will be accomplished by applying x-ray diffraction techniques to determine the ensemble average of the sequence of labels along the individual elements of crystalline DNA. X-ray lase… more
Date: October 11, 1990
Creator: Trebes, J.; Annese, C.; Birdsall, D.; Brase, J.; Gray, J.; Lane, S. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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