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in creator/contributor: "Ley, R.D."

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Studies on the multistage nature of radiation carcinogenesis

With low dose levels of ionizing or ultraviolet radiation, the number of initiation events exceeds the number of tumors that grow to a detectable size. Ionizing radiation, which is a complete carcinogen, appears to be a more effective initiator than an enhancer or promoter. However, the initiation and promotion aspects of ionizing radiation have been studied in very few organ systems. In the case of UVR, with or without photosensitizers such as psoralens, the requirement of a relatively large n… more

Date: January 1, 1980

Creator: Fry, R.J.M.; Ley, R.D.; Grube, D. & Staffeldt, E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Possibilities and problems in uv radiation carcinogenesis experiments

Experiments were designed to solve problems in dose-response relationships in uv-induced carcinogenesis. Two strains of hairless mice were exposed to 300 to 400 nm, 320 to 400 nm, and 365 nm wavelength emissions following exposure to 8-methoxy-psoralen; various fractionation regimes were used. Results showed that the number of psoralen-DNA crosslinks per cell increased linearly with dose. The importance of wavelength in the initiation and the expression of tumors is emphasized. (HLW)

Date: January 1, 1978

Creator: Fry, R.J.M.; Ley, R.D. & Grube, D.