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in creator/contributor: "Freimuth, P."

Radiolabeled Adenoviral Sub-unit Proteins for Molecular Imaging and Therapeutic Applications in Oncology

The objective of this project was to develop and optimize new ligand systems, based on adenoviral vectors (intact adenovirus, adeno-viral fiber protein, and the knob protein), for delivering suitable radionuclides into tumor cells for molecular imaging and combined gene/radionuclide therapy of cancer.

Date: October 6, 2004

Creator: Srivastava, S.; Meinken, G.; Springer, K. Awasthi, V. & Freimuth, P.

Item Type: Presentation

Partner: UNT Libraries Government Documents Department

open access

ADENOVIRUS INTERACTION WITH ITS CELLULAR RECEPTOR CAR.

The mechanism of adenovirus attachment to the host cell plasma membrane has been revealed in detail by research over the past 10 years. It has long been known that receptor binding activity is associated with the viral fibers, trimeric spike proteins that protrude radially from the vertices of the icosahedral capsid (Philipson et al. 1968). In some adenovirus serotypes, fiber and other virus structural proteins are synthesized in excess and accumulate in the cell nucleus during late stages of i… more

Date: August 2001

Creator: Howitt, J.; Anderson, C. W. & Freimuth, P.

Item Type: Book