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Expression of cytoskeletal and matrix genes following exposure to ionizing radiation: Dose-rate effects and protein synthesis requirements

Description: Experiments were designed to examine the effects Of radiation dose-rate and of the protein synthesis inhibitor cycloheximide on expression of cytoskeletal elements ({gamma}- and {beta}-actin and {alpha}-tubulin) and matrix elements (fibronectin) in Syrian hamster embryo cells. Past work from our laboratory had already demonstrated optimum time points and doses for examination of radiation effects on accumulation of specific transcripts. Our results here demonstrated little effect of dose-rate f… more
Date: May 1, 1994
Creator: Woloschak, G. E.; Felcher, P. & Chang-Liu, Chin-Mei
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Expression of cytoskeletal and matrix genes following exposure to ionizing radiation: Dose-rate effects and protein synthesis requirements

Description: Experiments were designed to examine the effects of radiation dose-rate and of the protein synthesis inhibitor cycloheximide on expression of cytoskeletal elements ({gamma}- and {beta}-actin and {alpha}-tubulin) and matrix elements (fibronectin) in Syrian hamster embryo cells. Results demonstrated little effect of dose-rate for JANUS fission-spectrum neutrons when comparing expression of either a-tubulin or fibronectin genes. Past work had already documented similar results for expression of ac… more
Date: December 31, 1993
Creator: Woloschak, G. E.; Felcher, P. & Chang-Liu, Chin-Mei
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Combined effects of ionizing radiation and cycloheximide on gene expression

Description: Experiments were done to determine the effects of ionizing radiation exposure on expression of genes following exposure of Syrian hamster embryo (SHE) cells to the protein synthesis inhibitor cycloheximide (including such genes as {beta}-actin, c-fos, H4-histone, c-myc, c-jun, Rb, and p53). Results revealed that when ionizing radiations (either fission-spectrum neutrons or {gamma}-rays) were administered 15 min following the cycloheximide treatment of SHE cells, the radiation exposure reduced c… more
Date: November 1, 1993
Creator: Woloschak, G. E.; Felcher, P. & Chang-Liu, Chin-Mei
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Expression of cytoskeletal and matrix genes following exposure to ionizing radiation: Dose-rate effects and protein synthesis requirements

Description: Experiments were designed to examine the effects of radiation dose-rate and of the protein synthesis inhibitor cycloheximide on expression of cytoskeletal elements ({gamma}- and {beta}-actin and {alpha}-tubulin) and matrix elements (fibronectin) in Syrian hamster embryo cells. Past work from our laboratory had already demonstrated optimum time points and doses for examination of radiation effects on accumulation of specific transcripts. Our results here demonstrated little effect of dose-rate f… more
Date: December 31, 1992
Creator: Woloschak, G. E.; Felcher, P. & Chang-Liu, Chin-Mei
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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