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in subjects: "Vertebrates 560152* -- Radiation Effects On Animals-- Animals"  
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Radiation induced micrencephaly in guinea pigs

Description: A brain weight deficit of about 70 mg was induced at doses of approximately 75-mGy and a deficit of 60 mg was induced at 100 mGy. This confirms the effects projected and observed by Wanner and Edwards. Although the data do not demonstrate a clear dose-response relationship between the 75-mGy and 100-mGy groups, the data are statistically consistent with a dose-response effect because of the overlapping confidence intervals. The lack of a statistically significant observation is most likely rela… more
Date: January 1, 1991
Creator: Wagner, L.K.; Johnston, D.A. & Felleman, D.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Radiogenic neoplasia in thyroid and mammary clonogens

Description: We have developed rat thyroid and mammary clonogen transplantation systems for the study of radiogenic cancer induction at the target cell level in vivo. The epithelial cell populations of both glands contain small subpopulations of cells which are capable of giving rise to monoclonal glandular structures when transplanted and stimulated with appropriate hormones. During the end of the last grant year and the first half of the current grant year, we have completed analyses and summarized for pu… more
Date: May 31, 1991
Creator: Clifton, K.H.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Hematopoietic cell crisis: An early stage of evolving myeloid leukemia following radiation exposure

Description: Under select radiological conditions, chronic radiation exposure elicits a high incidence of myeloproliferative disease, principally myeloid leukemia (ML), in beagles. Previously we demonstrated that for full ML expression, a four-stage preclinical sequence is required, namely (1) suppression, (2) recovery, (3) accommodation, and (4) preleukemic transition. Within this pathological sequence, a critical early event has been identified as the acquisition of radioresistance by hematopoietic progen… more
Date: January 1, 1990
Creator: Seed, T.M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Low dose neutron late effects: Cataractogenesis

Description: The work is formulated to resolve the uncertainty regarding the relative biological effectiveness (RBE) of low dose neutron radiation. The study exploits the fact that cataractogenesis is sensitive to the inverse dose-rate effect as has been observed with heavy ions and was an endpoint considered in the follow-up of the A-bomb survivors. The neutron radiations were initiated at the Radiological Research Accelerator facility (RARAF) of the Nevis Laboratory of Columbia University. Four week old (… more
Date: December 1, 1991
Creator: Worgul, B. V.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Probing altered hematopoietic progenitors of preleukemic dogs with JANUS fission neutrons

Description: Toward the goal of developing basic insights to mechanisms of radiation leukemogenesis, the authors have developed a canine model that responds to protracted courses of low-daily-dose gamma irradiation with high incidences of myeloproliferative disease (MPD), principally myeloid leukemia. Using this model system, the authors have identified and partially characterized a four-phase preclinical sequence in the induction of MPD, including (1) suppression, (2) recovery, (3) accommodation, and (4) p… more
Date: January 1, 1990
Creator: Seed, T.M. & Kaspar, L.V.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Protection by WR-151327 against late-effect damage from fission-spectrum neutrons

Description: Considerable effort has been expended to develop chemical agents capable of modifying radiation-induced damage to biological systems. The authors describe here differences in the radioprotective effect of WR-151327, depending on the sex of the animal and the post-irradiation time interval considered. The greatest effect in female animals is prior to 805 days post irradiation. The greater protection in male animals is seen during the time increment following 850 days after irradiation. While it … more
Date: January 1, 1990
Creator: Grdina, D. J. (Argonne National Lab., IL (USA) Chicago Univ., IL (USA). Dept. of Radiation and Cellular Oncology); Wright, B. J. & Carnes, B. A. (Argonne National Lab., IL (USA))
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

(Oncogenic action of ionizing radiation)

Description: An extensive experiment involving approximately 400 rats exposed to the neon ion beam at the Bevalac in Berkeley, CA and to electrons is nearing completion. The carcinogenicity of energetic electrons was determined for comparison with the neon ion results. As in past reports we will describe progress in three areas corresponding to the specific aims of the proposal: (1) carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; (2) DNA strand breaks in th… more
Date: January 1, 1990
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Oncogene amplification detected by in situ hybridization in radiation induced rat skin tumors. [C-myc:a3]

Description: Oncogene activation may play an important role in radiation induced carcinogenesis. C-myc oncogene amplification was detected by in situ hybridization in radiation-induced rat skin tumors, including squamous and basal cell carcinomas. In situ hybridization was performed with a biotinylated human c-myc third exon probe, visualized with an avidin-biotinylated alkaline phosphate detection system. No c-myc oncogene amplification was detected in normal rat skin at very early times after exposure to … more
Date: February 1, 1991
Creator: Jin., Yi
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The oncogenic action of ionizing radiation on rat skin

Description: Progress has occurred in several areas corresponding to the specific aims of the proposal: (1) Progression and multiple events in radiation carcinogenesis of rat skin as a function of LET; (2) cell cycle kinetics of irradiated rat epidermis as determined by double labeling and double emulsion autoradiography; (3) oncogene activation detected by in situ hybridization in radiation-induced rat skin tumors; (4) amplification of the c-myc oncogene in radiation-induced rat skin tumors as a function o… more
Date: January 1, 1991
Creator: Burns, F.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The oncogenic action of ionizing radiation on rat skin

Description: The multistage theory of carcinogenesis specifies that cells progress to cancer through a series of discrete, irreversible genetic alterations, but data on radiation-induced cancer incidence in rat skin suggests that an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to an electron beam (LET=0.34 keV/[mu]), a neon ion beam (LET=45) or an argon ion beam (LET=125). The rats were observed for tumors at least 78 weeks with squamous and basal … more
Date: January 1, 1992
Creator: Burns, F. J. & Garte, S. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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