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in subjects: "550900 -- Pathology"  
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Radiation toxicology

Description: The extensive studies on both human and experimental animal populations have provided information that allows radiation protection standards to be set with greater confidence than for most if not all other carcinogenic agents. Furthermore, both international and national advisory bodies are continually updating the risk estimates and the standards as new information is available. However, it is clear that we need models that take into account the multistage nature of carcinogenesis. Studies in … more
Date: January 1, 1979
Creator: Fry, R.J.M.; Storer, J.B. & Ullrich, R.L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Effects of chemical carcinogens of hemopoiesis, immunopoiesis and viral oncogenesis. Technical progress report, December 1, 1977--September 30, 1978. [Mechanisms of potentiation of viral leukemogenesis by MMS, benzopyrene, and DMBA]

Description: During the past year we have concentrated on defining the circumstances under which methyl methanesulfonate (MMS), benzo(a) pyrene (BP), and 7,12-dimethylbenz(a)anthracene (DMBA) interact with Friend virus (FLV) to produce leukemia. The optimum scheduling for each and also the effective dose levels of the chemicals have been partially determined. There are at least three critical factors which govern whether or not a leukemogenic interaction can be shown between the chemical agents and the viru… more
Date: October 1, 1978
Creator: OKunewick, J.P.; Raikow, R.B. & Meredith, R.F.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Study on the induction of thyroid tumors in rats using x irradiation in conjunction with a goitrogen. [1 methyl--2 mercaptoimidazole (methimazole)]

Description: The influence of acute localized thyroid x irradiation and chronic goitrogen administration, separately or combined, on thyroid tumor formation in mature female rats was studied. In the first experiment, the radiation doses were 0, 80, 160, 320, or 640 rads, and the dosages of goitrogen were 0, 4, or 40 parts per million (ppM) of 1 methyl - 2 mercaptoimidazole (MMI). The incidence of rats with thyroid tumors in any treated group receiving 0 or 4 ppM MMI was not significantly greater than the in… more
Date: January 1, 1979
Creator: Mahler, P.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Effect of chemical carcinogens on hematopoietic stem cells: temporal correlation between methyl methane sulfonate induced depression of CFU-S and potentiation of Friend viral leukemogenesis in vivo. [Mice]

Description: Methyl methane sulfonate (MMS) was shown to reduce the number of transplantable pluripotent hematopoietic stem cells (CFU-S) in the mouse spleen. A mild depression in CFU-S numbers was seen as early as 1 hr after injection of the chemical carcinogen. Maximal depression was found to be at 5 hrs, followed by a recovery of up to 75% of normal levels by 24 hrs. Comparison of the data with earlier reslts which demonstrated a potentiating effect of MMS on viral leukemogenesis in vivo revealed a good … more
Date: May 1, 1979
Creator: Raikow, R. B.; OKunewick, J. P.; Meredith, R. F.; Brozovich, B. J. & Seeman, P. R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Test for detection of clustering over time. [Statistical study of spontaneous abortions in NYC]

Description: The use of the scan statistic in testing for clustering in time is discussed with particular reference to a reported clustering of trisomies in spontaneous abortions in New York City (spontaneous abortions have been used on occasion to monitor environmental health effects). The scan statistic is the maximum number of observed cases in an interval of preselected length, as the interval is allowed to scan, or slide along, the time frame of interest. A table of the lower tail of the distribution o… more
Date: March 1, 1979
Creator: Wallenstein, S
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Cellular proliferation and regeneration following tissue damage. Progress report. [X radiation; rabbit lenses]

Description: Studies were conducted on the following research projects: effects of x radiation on rabbit lenses; DNA synthesis and mitosis in cultured lenses; serum dependency and actinomycin D sensitivity; changes in ultrastructure; injury-induced growth of vascular endothelium; corneal neovascularization following injury; and human cataractous lenses. (HLW)
Date: January 1, 1977
Creator: Harding, C.V.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Effects of rainfall acidification on plant pathogens

Description: Wind-blown rain, rain splash, and films of free moisture play important roles in the epidemiology of many plant diseases. The chemical nature of the aqueous microenvironment at the infection court is a potentially significant factor in the successful dissemination, establishment, and survival of plant pathogenic microorganisms. Acidic rainfall has a potential for influencing not only the pathogen, but also the host organism, and the host-pathogen complex. Although host-pathogen interactions add… more
Date: January 1, 1978
Creator: Shriner, D. S. & Cowling, E. B.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Behavior as a sentry of metal toxicity

Description: Many of the toxic properties of metals are expressed as behavioral aberrations. Some of these arise from direct actions on the central nervous system. Others arise from primary events elsewhere, but still influence behavior. Toxicity may be expressed either as objectively measurable phenomena, such as ataxia, or as subjective complaints, such as depression. In neither instance is clinical medicine equipped to provide assessments of subtle, early indices of toxicity. Reviewers of visual disturba… more
Date: January 1, 1978
Creator: Weiss, B.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Brain plasticity, memory, and aging: a discussion

Description: It is generally assumed that memory faculties decline with age. A discussion of the relationship of memory and aging and the possibility of retarding the potential decline is hampered by the fact that no satisfactory explanation of memory is available in either molecular or anatomical terms. However, this lack of description of memory does not mean that there is a lack of suggested mechanisms for long-term memory storage. Present theories of memory usually include first, neurophysiological or e… more
Date: December 1, 1977
Creator: Bennett, E. L. & Rosenzweig, M. R.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Uranium miner lung cancer study. Progress report for period, July 1, 1977--July 1 1978

Description: This study was initiated in 1957 by the U.S. Public Health, and many facets of this project are reaching final objectives. Many new studies have developed in the course of this study and will continue. The projects supported by The Department of Energy during the past year are of utmost importance and consist of: (a) collection of material from uranium miners known to have cancer of the lung into a tumor registry; (b) completion and publication of the Manual on Pulmonary Cytology; (c) regressio… more
Date: September 15, 1978
Creator: Saccomanno, G.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Lymphocyte blastogenesis in the diagnosis of tuberculosis in cattle

Description: Considerable progress has been made towards the eradication of tuberculosis in cattle in the United States. No reliable blood test has been developed for detecting infected animals. An in vitro test for tuberculosis must have a high level of sensitivity with adequate specificity to differentiate infections due to Mycobacterium bovis and those caused by other mycobacteria. Moreover, it would be desirable that the test system be simple ad readily automated. The accuracy of lymphocyte immunostimul… more
Date: January 1, 1977
Creator: Thoen, C. O.; Muscoplat, C. C.; Cram, L. S.; Jarnagin, J. L.; Johnson, D. C. & Pietz, D. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Genetic influence on hypertension induced by cadmium in Dahl hypertension-resistant and hypertension-sensitive rats

Description: Dahl hypertension-resistant (R) and hypertension-sensitive (S) rats, with opposite genetically controlled propensities for hypertension, were used to determine if cadmium-induced hypertension was also dependent upon genetic predisposition. When intraperitoneal injections of cadmium (1 and 2 mg/kg) were given to male and female R and S rats maintained under ordinary laboratory conditions, female S rats manifested a significant increase in blood pressure which persisted for 16 weeks, whereas the … more
Date: January 1, 1976
Creator: Ohanian, E V; Dahl, L K & Iwai, J
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Inborn anemias in mice. Progress report to accompany twenty-first renewal proposal, 1 May 1975--30 April 1976

Description: Progress is reported on studies on hereditary anemias of mice. At present under study are four macrocytic anemias, four hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, and the autoimmune hemolytic anemia of NZB. Each of these blood dyscrasias is caused by the action of a unique mutant gene, each of which determines the structure of different intracellular molecules, and thus controls a different metabolic process. Thus our wide… more
Date: May 15, 1976
Creator: Russell, E. S. & Bernstein, S. E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Inborn anemias in mice. Comprehensive progress report to accompany twenty-first renewal proposal, 1 May 1973--30 April 1976

Description: Progress is reported on the delineation of inborn anemias of the laboratory mouse, carried out by preparation of genetically homogeneous stocks segregating only for anemia-producing genes; by descriptions of each condition at all stages in the life history; by determination of tissue-sites of primary gene action through transplantation and parabiosis experiments; by analysis of reactions of normal and anemic mice to a variety of stressful stimuli, including x-irradiation and hypoxia; and by his… more
Date: May 1, 1976
Creator: Russell, E. S. & Bernstein, S. E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Studies on virus-induced cell fusion. Progress report, May 1, 1976--July 31, 1977

Description: The cell fusion process of Herpes simplex virus has been characterized as regards macromolecular synthesis and post-macromolecular synthesis events. Studies with actinomycin D revealed that the critical period for RNA synthesis associated with cell fusion was 2 to 4 hr after infection, studies with cycloheximide showed that the critical period for protein synthesis was 3 to 5.5 hr after infection, and studies with 2-deoxyglucose showed that the critical period for glycosylation was 5 to 7 hr af… more
Date: January 1, 1977
Creator: Person, S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Environmental contaminants as origins of disordered behavior

Description: Behavioral toxicology studies the behavioral effects of contaminants, such as heavy metals, in environmental and occupational settings. A classic example of metal poisoning with behavioral effects is Pink Disease, or acrodynia, due to mercurous chloride intoxication in children. Thalidomide is a more prominent example. Behavioral changes, unlike tangible consequences of pollution, are difficult to perceive as dangers and to correct. Other examples of environmental pollutants causing behavioral … more
Date: January 1, 1978
Creator: Weiss, B.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Temporal aspects of tumorigenic response to individual and mixed carcinogens. [Response of mouse skin to benzo(a)pyrene]

Description: Results are reported from experiments that involved either single or multiple doses of benzo(a)pyrene in mouse skin followed by prolonged observation. Preliminary results indicate linearity in dose and time and no evidence of recovery or enhancement for multiple doses of initiator given for extended periods of time. (auth)
Date: February 1, 1976
Creator: Albert, R. E. & Burns, F. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Tumorigenic action of beta, proton, alpha, and electron radiation on the rat skin. Progress report, August 1, 1977--January 31, 1979

Description: Epithelial tumors are induced reproducibly in rat skin exposed to ionizing radiation, ultraviolet light, or polycyclic aromatic hydrocarbons. For these carcinogens, the comparative risk of tumor formation is being examined for clues to the generality of action and the mode of interaction of diverse carcinogens. Molecular lesions, such as, pyrimidine dimers and single-strand breaks in DNA have been measured as a basis for assessment of cellular dose. Dose-response for single doses, time response… more
Date: January 1, 1979
Creator: Burns, F. J. & Albert, R. E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Tissue Enzyme Changes in Parabiotic Rats with Subcutaneous Lymphoma

Description: A solid lymphoma was implanted into normal rats and into one partner of parabiotic pairs. Appreciable decreases in hepatic ornithine aminotransferase and arginase occurred about a week earlier (4 to 6 days after implantation) in single than in parabiotic hosts. By 18 to 21 days significant decreases in both enzymes were also apparent in the host partner. The hepatic thymidine kinase showed a 5-fold elevation in single hosts 4 days after implantation; by 14 days its levels were about 200 times a… more
Date: January 1, 1977
Creator: Herzfeld, Annemarie; Greengard, Olga & Warren, Shields
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Impact of thermal loading and other water quality parameters on the epizootiology of Epistylis and Aeromonas infections of centrarchids. Progress report, September 1, 1976--July 30, 1977

Description: During the past year, mounting evidence has been accumulated which indicates that the causative agent for red-sore disease among bass is the bacterium, Aeromonas hydrophila, and not the ciliate, Epistylis, as suggested in previous literature. Red-sore disease among bass in Par Pond continues to be highly seasonal with peak periods of infection occurring in spring and summer, with declining levels in fall and summer. The disease continues to be more prevalent among bass from thermally altered ar… more
Date: August 1, 1977
Creator: Esch, Gerald W. & Dimock, Ronald V.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Toxicology and metabolism of nickel compounds. Progress report, December 1, 1974--November 30, 1975. [97433ONE]

Description: The toxicology and metabolism of nickel compounds (NiCl/sub 2/, Ni/sub 3/S/sub 2/, NiS, and Ni powder) were investigated in rats and hamsters. The new knowledge has included: demonstration that hyperglucagonemia is primarily responsible for the acute hyperglycemic effect of parenteral Ni(II) in rats; demonstration that parenteral injection of Ni(II) in rats produces acute nephropathy with proteinuria and amino aciduria, and with ultrastructural lesions of renal glomeruli and tubules; confirmati… more
Date: August 15, 1975
Creator: Sunderman, F. W., Jr.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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