Genetic Control or Repair and Adaptive Response to Low-Level DNA Damage
Description:
Research was focused on how a single double-strand break - a model of low-dose ionizing radiation-induced DNA damage - could be studied in a simple model system, budding yeast. Breaks were induced in several different ways. We used the site-specific HO endonuclease to create a single DSB in all cells of the population so that its fate could be extensively analyzed genetically and molecularly. We also used two heterologous systems, the plant DS element and the Rag1/Rag2 proteins, to generate dif…
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Date:
October 5, 2009
Creator:
Haber, J. E.
Item Type:
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Report
Partner:
UNT Libraries Government Documents Department