Mutation of Polaris, an Intraflagellar Transport Protein, Shortens Neuronal Cilia
Description:
Primary cilia are non-motile organelles having 9+0 microtubules that project from the basal body of the cell. While the main purpose of motile cilia in mammalian cells is to move fluid or mucus over the cell surface, the purpose of primary cilia has remained elusive for the most part. Primary cilia are shortened in the kidney tubules of Tg737orpk mice, which have polycystic kidney disease due to ciliary defects. The product of the Tg737 gene is polaris, which is directly involved in a microtub…
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Date:
August 2005
Creator:
Mahato, Deependra
Partner:
UNT Libraries