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in subjects: "550900 -- Pathology"  
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Pulmonary macrophages: Phenomena associated with the particle overload'' condition

Description: Numerous lines of evidence support the generalization that alveolar macrophage (AM)-mediated particle clearance, or the transport of particle-containing AM from the alveoli out of the lung via the mucociliary apparatus, is a prominent mechanism that determines the pulmonary retention characteristics of relatively insoluble particles. Studies have also shown that the alveolar deposition of excessive burdens of particles with even low intrinsic cytotoxicity can result in impairments of the AM-med… more
Date: January 1, 1993
Creator: Lehnert, B. E.; Sebring, R. J. (Los Alamos National Lab., NM (United States)) & Oberdoerster, G. (Rochester Univ., NY (United States))
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

DM-CSF stimulated proliferation of rat alveolar macrophages and the effects of differing particulate burden levels in alveolar macrophages on the proliferative response

Description: Particles are gradually redistributed among the lung's population of alveolar macrophages (AM) at times well after they were originally deposited in the lung. One mechanism that may underlie this particle redistribution phenomenon'' is the in situ replication of particle-containing AM and the allocation of particles from dividing AM to daughter cells. Little is known about how the abilities of AM to proliferate may be affected by the containment of particles; conceivably, AM proliferation may b… more
Date: January 1, 1993
Creator: Pendergrass, D.; Valdez, Y. E. & Lehnert, B. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

SNODOG Glossary: Part 1, Introduction

Description: The SNODOG Glossary is used by the DOE-supported life-span beagle studies to describe medical observations in a standardized format. It is an adaptation of the human medical glossary, SNOMED, which lists 107,165 terms. Each of the five laboratories, Argonne National Laboratory, the Inhalation Toxicology Research Institute, the Pacific Northwest Laboratory, the University of California at Davis, and the University of Utah, has selected an appropriate subset from the published SNOMED glossary and… more
Date: April 15, 1993
Creator: Watson, C. R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

PCR detection of retinoblastoma gene deletions in radiation-induced mouse lung adenocarcinomas

Description: From 1971 to 1986, Argonne National Laboratory conducted a series of large-scale studies of tumor incidence in 40,000 BCF[sub 1] mice irradiated with [sup 60]Co [gamma] rays or JANUS fission-spectrum neutrons; normal and tumor tissues from mice in these studies were preserved in paraffin blocks. A polymerase chain reaction (PCR) technique has been developed to detect deletions in the mouse retinoblastoma (mRb) gene in the paraffin-embedded tissues. Microtomed sections were used as the DNA sourc… more
Date: January 1, 1993
Creator: Churchill, M. E.; Gemmell, M. A. & Woloschak, G. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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