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Comparative mutagenesis of human cells in vivo and in vitro

Description: This report discusses measuring methods of point mutations; high density cell cultures for low dose studies; measurement and sequence determination of mutations in DNA; the mutational spectra of styrene oxide and ethlyene oxide in TK-6 cells; mutational spectrum of Cr in human lymphoblast cells; mutational spectra of radon in TK-6 cells; and the mutational spectra of smokeless tobacco. (CBS)
Date: May 1, 1992
Creator: Thilly, W.G.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Radiation physics, biophysics, and radiation biology

Description: The following research programs from the Center for Radiological Research of Columbia University are described: Design and development of a new wall-less ultra miniature proportional counter for nanodosimetry; some recent measurements of ionization distributions for heavy ions at nanometer site sizes with a wall-less proportional counter; a calculation of exciton energies in periodic systems with helical symmetry: application to a hydrogen fluoride chain; electron energy-loss function in polynu… more
Date: May 1, 1992
Creator: Hall, E.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Repair of uv damaged DNA: Genes and proteins of yeast and human

Description: Our objectives are to determine the molecular mechanism of the incision step of excision repair of ultraviolet (UV) light damaged DNA in eukaryotic organisms, using the yeast Saccharomyces cerevisiae as a model system, and to study the human homologs of yeast excision repair and postreplication repair proteins progress is described.
Date: April 1, 1992
Creator: Prakash, L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Life sciences and environmental sciences

Description: The DOE laboratories play a unique role in bringing multidisciplinary talents -- in biology, physics, chemistry, computer sciences, and engineering -- to bear on major problems in the life and environmental sciences. Specifically, the laboratories utilize these talents to fulfill OHER's mission of exploring and mitigating the health and environmental effects of energy use, and of developing health and medical applications of nuclear energy-related phenomena. At Lawrence Berkeley Laboratory (LBL… more
Date: February 1, 1992
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Nanodosimetry and nanodosimetric-based models of radiation action for radon alpha particles

Description: The objective of our research work is to provide -- with the aid of biophysical models of radiation action -- information on human risks following exposure to radon alpha particles. The approach proposed consists of (1) developing appropriate models (parametric and non-parametric) for alpha radiation induction of relevant end points (survival, cellular transformation), (2) providing an accurate physical characterization of the particle tracks in terms of nanodosimetric distributions, (3) suppor… more
Date: January 1, 1992
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Savannah River Site 1992 ALARA goals

Description: The ALARA Goals for the Savannah River Site (SRS) for 1992 have been established by the operating Divisions/Departments and totaled for the anticipated scope of sitewide work. Goals for maximum individual exposure and personnel contamination cases have been reduced from 1991 actual data. The goal for assimilations of radionuclides remains at zero. The 633.20 rem cumulative exposure goal is constituted of special work operations and base routine operations, respectively 244.68 rem and 388.52 rem… more
Date: January 1, 1992
Creator: Smith, L. S.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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An improved method for producing radiation hybrids applied to human chromosome 19

Description: At the initiation of the grant we had just produced radiation hybrids from a monochromosomal microcell hybrid containing human chromosome 19 as its only human component. Radiation hybrids were produced using doses of radiation ranging from 1000--8000 rads. Lethally irradiated cells were then fused to hamster recipients (CHTG49) and selected for growth in histidinol. Approximately 240 clones were isolated and 75 clones were expanded for the isolation of DNA. This report describes in situ hybridi… more
Date: January 1, 1992
Creator: Jackson, C.L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The Radiological Research Accelerator Facility

Description: The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Center for Radiological Research (CRR) -- formerly the Radiological Research Laboratory (RRL) -- of Columbia University, and its operation is supported as a National Facility by the US Department of Energy (DOE). As such, RARAF i… more
Date: May 1, 1992
Creator: Hall, E.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Implications of recent ICRP recommendations for risk assessments for radioactive waste disposal and cleanup

Description: The International Commission on Radiological Protection (ICRP) adopted a new set of recommendations in November 1990 which were issued at ICRP Publication No. 60 in March 1991. These recommendations incorporate new radiobiological information and outline a comprehensive system of radiological protection. This paper evaluates the implications of these new recommendations vis a vis risk assessments for radioactive waste disposal and remediation of radioactively contaminated sites.
Date: January 1, 1992
Creator: Devgun, J. S.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Laser-induced contained-vaporization in tissue

Description: When a transparent liquid or solid medium is present in front of an opaque target being irradiated by an intense laser beam, then the expansion of hot vapors generated (at the interface between the medium and the target) by the irradiant heating of the target is restrained by the medium. The tamping effect of the overlying liquid or solid can cause a much larger fraction of the deposited energy to go into kinetic energy, which leads to enhanced tissue disruption, compared to when a gas or vacuu… more
Date: January 1, 1992
Creator: Dingus, R. S.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Single track effects, biostack and risk assessment

Description: This talk addresses the single-track nature of the space radiation environment, and points out the importance of single hits'' in the evaluation of radiation risk for long-term missions occurring outside the earth's magnetic field. A short review is made of biological objects found to show increased effects when hit'' by a single heavy charged-particle in space. A brief discussion is given of the most provocative results from the bacterial spore B. subtilis: experimental evidence that tracks ca… more
Date: October 1, 1992
Creator: Curtis, S.B.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Radiation damage to DNA

Description: Our goal is to calculate the probability to eject electrons from DNA by charged particles that pass near the macromolecule as they slow down in an aqueous medium that contains DNA in low concentration. This process is illustrated for a particle of charge Ze and velocity v, where impact parameters b{sub 1}, b{sub 2}, and b{sub 3} indicate the distances between the trajectory and a phosphate group, a base, and a sugar moiety, respectively. In the present state of our theoretical development, we m… more
Date: April 1, 1992
Creator: Miller, J. H.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Single track effects, biostack and risk assessment

Description: This talk addresses the single-track nature of the space radiation environment, and points out the importance of single ``hits`` in the evaluation of radiation risk for long-term missions occurring outside the earth`s magnetic field. A short review is made of biological objects found to show increased effects when ``hit`` by a single heavy charged-particle in space. A brief discussion is given of the most provocative results from the bacterial spore B. subtilis: experimental evidence that track… more
Date: October 1, 1992
Creator: Curtis, S. B.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Implications of recent ICRP recommendations for risk assessments for radioactive waste disposal and cleanup

Description: The International Commission on Radiological Protection (ICRP) adopted a new set of recommendations in November 1990 which were issued at ICRP Publication No. 60 in March 1991. These recommendations incorporate new radiobiological information and outline a comprehensive system of radiological protection. This paper evaluates the implications of these new recommendations vis a vis risk assessments for radioactive waste disposal and remediation of radioactively contaminated sites.
Date: April 1, 1992
Creator: Devgun, J. S.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Factors affecting mutational specificity induced by ionizing radiation and oxidizing radicals. Progress report

Description: We propose to analyze the factors affecting the specificity of mutational change as induced by ionizing radiation and oxidizing radicals. We want to understand not only the rules the affect base substitution but also the mechanisms(s) by which additions and deletions are produced, since deletions are a common consequence of radiation. We wish to carry out this analysis in an in vitro mutation system that permits us to analyze the role of base sequence, of polymerase and of mutagenic agent. Our … more
Date: July 1, 1992
Creator: Strauss, B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The Radiological Research Accelerator Facility. Progress report, December 1, 1991--November 30, 1992

Description: The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Center for Radiological Research (CRR) -- formerly the Radiological Research Laboratory (RRL) -- of Columbia University, and its operation is supported as a National Facility by the US Department of Energy (DOE). As such, RARAF i… more
Date: May 1, 1992
Creator: Hall, E. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Radiation physics, biophysics, and radiation biology. Progress report, December 1, 1991--November 30, 1992

Description: The following research programs from the Center for Radiological Research of Columbia University are described: Design and development of a new wall-less ultra miniature proportional counter for nanodosimetry; some recent measurements of ionization distributions for heavy ions at nanometer site sizes with a wall-less proportional counter; a calculation of exciton energies in periodic systems with helical symmetry: application to a hydrogen fluoride chain; electron energy-loss function in polynu… more
Date: May 1, 1992
Creator: Hall, E. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

[Theory of relative biological effectiveness]. Annual technical progress report, 1 January 1992--31 December 1992

Description: Research continued on relative biological effectiveness, in the following areas: radial distribution of dose about the path of an energetic heavy ion; the response of E. Coli mutants to ionizing radiations; the application of a fragmentation model to to the calculation of cell survival and mutation with heavy ion beams; biological radiation effects from gamma radiation and heavy ion beams on organisms; cancer induction in the Harderian Gland by HZE particles; and effects of low dose radiations.… more
Date: June 15, 1992
Creator: Katz, R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The assessment of risks from exposure to low-levels of ionizing radiation

Description: This report is concerned with risk assessments for human populations receiving low level radiation doses; workers routinely exposed to radiation, Japanese victims of nuclear bombs, and the general public are all considered. Topics covered include risk estimates for cancer, mortality rates, risk estimates for nuclear site workers, and dosimetry.
Date: June 1992
Creator: Gilbert, E. S.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Activities of the National Academy of Sciences in relation to the Radiation Effects Research Foundation. Annual performance report, June 1, 1991--May 31, 1992

Description: This progress report relates progress in the various research projects evaluating the late health effects, both somatic and genetic, resulting from radiation exposure of the survivors of the atomic bombs at Hiroshima and Nagasaki, Japan. Considerable progress has been made in the collection and utilization of the various epidemiological data bases. These include the Life Span Study, (LSS) cohort, the Adult Health Study (AHS) cohort, the In Utero cohort, the leukemia registry and the F-1 Study p… more
Date: June 1, 1992
Creator: Edington, Charles W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Study of the atmospheric chemistry of radon progeny in laboratory and real indoor atmospheres. Progress report, July 1, 1991--June 30, 1992

Description: This report covers the second year of the 28 month grant current grant to Clarkson University to study the chemical and physical behavior of the polonium 218 atom immediately following its formation by the alpha decay of radon. Because small changes in size for activity result in large changes in the delivered dose per unit exposure, this behavior must be understood if the exposure to radon progeny and it dose to the cells in the respiratory tract are to be fully assessed. Two areas of radon pr… more
Date: July 1, 1992
Creator: Hopke, P. K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Study of the atmospheric chemistry of radon progeny in laboratory and real indoor atmospheres

Description: This report covers the second year of the 28 month grant current grant to Clarkson University to study the chemical and physical behavior of the polonium 218 atom immediately following its formation by the alpha decay of radon. Because small changes in size for activity result in large changes in the delivered dose per unit exposure, this behavior must be understood if the exposure to radon progeny and it dose to the cells in the respiratory tract are to be fully assessed. Two areas of radon pr… more
Date: July 1, 1992
Creator: Hopke, P. K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Radiation damage to DNA

Description: Our goal is to calculate the probability to eject electrons from DNA by charged particles that pass near the macromolecule as they slow down in an aqueous medium that contains DNA in low concentration. This process is illustrated for a particle of charge Ze and velocity v, where impact parameters b{sub 1}, b{sub 2}, and b{sub 3} indicate the distances between the trajectory and a phosphate group, a base, and a sugar moiety, respectively. In the present state of our theoretical development, we m… more
Date: April 1, 1992
Creator: Miller, J. H.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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