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Molecular targets, DNA breakage, DNA repair: Their roles in mutation induction in mammalian germ cells

Description: Variability in genetic sensitivity among different germ-cell stages in the mammal to various mutagens could be the result of how much chemical reaches the different stages, what molecular targets may be affected in the different stages and whether or not repair of lesions occurs. Several chemicals have been found to bind very strongly to protamine in late-spermatid and early-spermatozoa stages in the mouse. The chemicals also produce their greatest genetic damage in these same germ-cell stages.… more
Date: January 1, 1989
Creator: Sega, G.A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Trace element distribution in the rat cerebellum

Description: Spatial distributions and concentrations of trace elements (TE) in the brain are important because TE perform catalytic structural functions in enzymes which regulate brain function and development. We have investigated the distributions of TE in rat cerebellum. Structures were sectioned and analyzed by the Synchrotron Radiation Induced X-ray Emission (SRIXE) method using the NSLS X-26 white-light microprobe facility. Advantages important for TE analysis of biological specimens with x-ray micro… more
Date: October 1, 1989
Creator: Kwiatek, W. M.; Long, G. J.; Pounds, J. G.; Reuhl, K. R.; Hanson, A. L. & Jones, K. W.
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Partner: UNT Libraries Government Documents Department
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Mouse models for understanding human developmental anomalies

Description: The mouse experimental system presents an opportunity for studying the nature of the underlying mutagenic damage and the molecular pathogenesis of this class of anomalies by virtue of the accessibility of the zygote and its descendant blastomeres. Such studies could contribute to the understanding of the etiology of certain sporadic but common human malformations. The vulnerability of the zygotes to mutagens as demonstrated in the studies described in this report should be a major consideration… more
Date: January 1, 1989
Creator: Generoso, W.M.
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Partner: UNT Libraries Government Documents Department
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Inhaled /sup 147/Pm and/or total-body gamma radiation: Early mortality and morbidity in rats

Description: Rats were given doses of /sup 60/Co gamma radiation and/or lung burdens of /sup 147/Pm (in fused aluminosilicate particles) within lethal ranges in an experiment to determine and compare morbidity and mortality responses for the radiation insults within 1 year after exposure. Radiation-induced morbidity was assessed by measuring changes in body weights, hematologic parameters, and pulmonary-function parameters. Acute mortality and morbidity from inhaled promethium were caused primarily by radia… more
Date: May 1, 1989
Creator: Filipy, R. E.; Lauhala, K. E.; McGee, D. R.; Cannon, W. C.; Buschbom, R. L.; Decker, J. R. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Target-specific binding of immunoliposomes in vivo

Description: Our group at the University of Tennessee has been concentrating on using monoclonal antibody for targeting of a liposomal drug carrier system. This paper discusses our initial effort to target these liposomes using an organ-specific monoclonal antibody. 9 refs., 9 figs.
Date: January 1, 1989
Creator: Holmberg, E.; Maruyama, K.; Kennel, S.; Klibanov, A.; Torchilin, V.; Ryan, U. et al.
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Partner: UNT Libraries Government Documents Department
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Trends in radionuclide concentrations for selected wildlife and food products near the Hanford Site from 1971 through 1988

Description: From 1971 through 1988 at least 40 species of wildlife and 27 different types of food products were collected and analyzed for radionuclides as part of the Pacific Northwest Laboratory (PNL) Environmental Monitoring Program. This report summarizes the results of these analyses for sample types collected for all or most of the 18-year period. The objectives of this summary investigation were to identify long-term trends or significant year-to-year changes in radionuclide concentrations and, if p… more
Date: September 1, 1989
Creator: Eberhardt, L. E.; Cadwell, L. L.; Price, K. R.; Carlile, D. W. (Pacific Northwest Lab., Richland, WA (USA) & Alaska Dept. of Fish and Game, Juneau, AK (USA))
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Copper-67 labeled porphyrin localization in inflamed tissues

Description: A series of experiments compared the uptake of 5,10,15,20-tetrakis(4-carboxyphenyl) porphinato (/sup 67/Cu) copper(II), /sup 67/CuTCPP, by the lymph nodes of inflamed and two sets or control rats. The results demonstrate that /sup 67/CuTCPP localizes in greater concentration in inflamed lymph nodes than in noninflamed control lymph nodes. This enhanced uptake of /sup 67/CuTCPP by inflamed lymph nodes was 3.6 times greater than was the uptake by control lymph nodes. A time course study demonstra… more
Date: January 1, 1989
Creator: Cole, D. A.; Mercer-Smith, J. A.; Norman, J. K.; Bullington, K. P.; Roberts, J. C. & Lavellee, D. K.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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JANUS neutron irradiation of a mouse cell line containing a shuttle vector plasmid

Description: The study presented here represents the initial steps of our attempt to characterize JANUS neutron induced mutagenesis in mammalian cells. The approach which we are taking is to use a mammalian cell system which allows one to determine the actual changes in DNA base sequence which occur when a gene mutates. Recently, several systems have been described which make possible the rapid and unambiguous determination of DNA base sequence changes in genes of eukaryotic cells. In some of these systems,… more
Date: January 1, 1989
Creator: Nagy, B. (Central Inst. for Tumors, Zagreb (Yugoslavia)); Grdina, D.J. (Argonne National Lab., IL (USA)) & Ashman, C.R. (Chicago Univ., IL (USA))
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Radiolethal and genetic vulnerabilities of germ cells in the female mammal: Effects of tritium and other radiations compared

Description: Our focus is on the nature of the lethality target in very sensitive cells. In the mouse, several types of radiations have now been used, including /sup 3/H-Tdr incorporated into oocyte DNA, gamma rays delivered at various dose rates, 250 kVp x rays, neutrons of various energies, and three kinds of accelerated heavy ions (Si/sup 14 +/, Ar/sup 18 +/, Fe/sup 26 +/). We have shown that the lethality target in mouse immature oocytes is non-nuclear; it is equal in cross-sectional area to the entire … more
Date: January 1, 1989
Creator: Straume, T.; Kwan, T.C.; Goldstein, L.S. & Dobson, R.L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Recent developments in monoclonal antibody radiolabeling techniques

Description: Monoclonal antibodies (MAbs) have shown the potential to serve as selective carriers of radionuclides to specific in vivo antigens. Accordingly, there has been an intense surge of research activity in an effort to develop and evaluate MAb-based radiopharmaceuticals for tumor imaging (radioimmunoscintigraphy) and therapy (radioimmunotherapy), as well as for diagnosing nonmalignant diseases. A number of problems have recently been identified, related to the MAbs themselves and to radiolabeling te… more
Date: January 1, 1989
Creator: Srivastava, S.C. & Mease, R.C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Inhalation developmental toxicology studies: Teratology study of isoprene in mice and rats: Final report

Description: Isoprene, a reactive, branched diene, is used in large quantities in the manufacture of polyisoprene and as a copolymer in the synthesis of butyl rubber. The potential for isoprene to cause developmental toxicity was assessed in rodents, by exposing four groups each of Sprague-Dawley rats and Swiss (CD-1) mice to 0, 280, 1400, or 7000 ppM isoprene vapors, 6 h/day, 7 day/wk. Each treatment group consisted of 10 virgin females (for comparison), and approx.30 positively mated rats or mice. Positiv… more
Date: January 1, 1989
Creator: Mast, T. J.; Evanoff, J. J.; Stoney, K. H.; Westerberg, R. B.; Rommereim, R. L. & Weigel, R. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Inhalation developmental toxicology studies: Teratology study of methyl ethyl ketone in mice: Final report

Description: Methyl ethyl ketone (MEK) is a widely used industrial solvent which results in considerable human exposure. In order to assess the potential for MEK to cause developmental toxicity in rodents, four groups of Swiss (CD-1) mice were exposed to 0, 400, 1000 or 3000 ppM MEK vapors, 7 h/day, 7 dy/wk. Ten virgin females and approx.30 plug-positive females per group were exposed concurrently for 10 consecutive days (6--15 dg for mated mice). Body weights were obtained throughout the study period, and … more
Date: February 1, 1989
Creator: Mast, T. J.; Dill, J. A.; Evanoff, J. J.; Rommereim, R. L.; Weigel, R. J. & Westerberg, R. B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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