Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane
Description:
An essential feature of mammary gland differentiation during pregnancy is the formation of alveoli composed of polarized epithelial cells, which, under the influence of lactogenic hormones, secrete vectorially and sequester milk proteins. Previous culture studies have described either organization of cells polarized towards lumina containing little or no demonstrable tissue-specific protein, or establishment of functional secretory cells exhibiting little or no glandular architecture. In this p…
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Date:
February 1, 1989
Creator:
BARCELLOS-HOFF, M. H; AGGELER, J.; RAM, T. G & BISSELL, M. J
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