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Facility for in-vivo measurement of lithium

Description: Although lithium, an alkali metal is found in trace quantities in human, animal and plant tissue, no essential function has yet been ascribed to it. The concentration of Li in normal human tissue is in the 0.01 ..mu..g/g range, being largest in the cortical bone - 0.12 ..mu..g/g. Lithium was first used clinically for the treatment of mania. The most important clinical effect today is the prophylactic action or its ability to attenuate or prevent recurrences of manic and depressive episodes. Whi… more
Date: January 1, 1982
Creator: Vartsky, D.; Wielopolski, L.; Ellis, K.J. & Cohn, S.H.
Partner: UNT Libraries Government Documents Department
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Carbon-14 immobilization via the Ba(OH)/sub 2/8H/sub 2/O process

Description: The airborne release of /sup 14/C from various nuclear facilities has been identified as a potential biohazard due to the long half-life of /sup 14/C (5730 yrs) and the ease in which it may be assimilated into the biosphere. At Oak Ridge National Laboratory, technology is under development, as part of the Airborne Waste Management Program, for the removal and immobilization of this radionuclide. Prior studies have indicated that the /sup 14/C will likely exist in the oxidized form as CO/sub 2/ … more
Date: January 1, 1982
Creator: Haag, G. L.; Nehls, J. W. Jr. & Young, G. C.
Partner: UNT Libraries Government Documents Department
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Decommissioning of a tritium-contaminated laboratory

Description: A tritium laboratory facility at the Los Alamos National Laboratory, Los Alamos, New Mexico, was decommissioned in 1979. The project involved dismantling the laboratory equipment and disposing of the equipment and debris at an on-site waste disposal/storage area. The laboratory, constructed in 1953, was in service for tritium research and fabrication of lithium tritide components until 1974. The major features of the laboratory included 25 meters of gloveboxes and hoods, associated vacuum lines… more
Date: January 1, 1982
Creator: Harper, J. R. & Garde, R.
Partner: UNT Libraries Government Documents Department
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Radiolabelling of chemicals. [Chemical additives used in geothermal operations]

Description: Labeling of chemical additives with radioactive isotopes can solve numerous problems in geothermal operations. The physical and chemical behavior of many chemicals slated for geothermal operations can be studied with the required detail at the extremely low concentration of the commercially available (non-labeled) compounds. The problems of labeling and the basics of these radioactively labeled chemicals are described in this report. Conclusions of this study are: (1) chemicals labeled with rad… more
Date: June 22, 1982
Creator: Vetter, O.J. & Kandarpa, V.
Partner: UNT Libraries Government Documents Department
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ICF with momentum-rich beams

Description: A novel approach to obtain thermonuclear ignitions condition is suggested. Utilizing state-of-the-art ion source brightness parameters, and high gradient acceleration columns, it is possible to focus 10 kJ of heavy ions to a few mm spot, using a 1-meter radius spherical ion source. Heavy ion energies of 500 to 1000 keV have the velocity required for volume ignition of DT. The beam mass is typically 10 times greater than that of the DT which is to be burned. A spherical array of ion sources is e… more
Date: October 1, 1982
Creator: Maschke, A.W.
Partner: UNT Libraries Government Documents Department
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Monitoring tritium in air containing other radioactive gases

Description: A brief survey is presented of methods that have been developed for active tritium monitoring that may be applied to measure tritium concentrations in air containing /sup 13/N, /sup 16/N, and /sup 41/Ar produced by D-T neutrons. Included are instruments that employ current subtraction to achieve discriminations and others that selectively remove atmospheric water vapor from stream of activated air.
Date: September 1, 1982
Creator: Jalbert, Roland A.
Partner: UNT Libraries Government Documents Department
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1-/sup 11/C-D-glucose and related compounds

Description: The novel compounds 1-/sup 11/C-D-glucose, 1-/sup 11/C-D-mannose, 1-/sup 11/C-D-galactose, 2-/sup 11/C-D-glucose, 2-/sup 11/C-D-mannose and 2-/sup 11/C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal /sup 11/C-labeled cyanide followed by reduction with a Raney alloy in formic acid.
Date: January 26, 1982
Creator: Shiue, Chyng-Yann & Wolf, Alfred P.
Partner: UNT Libraries Government Documents Department
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Development of Bromine-77 from the LAMPF facility

Description: The objective of the work is to conduct the necessary studies required to evaluate the efficacy, potential benefit and role of bromine-77 labelled steroids in the detection and evaluation of treatment for hormone-dependent tumors. The synthetic goals of the project are to prepose estradiol derivatives which are labelled with bromine-77 at specific positions in the steroid nucleus. In addition, animal studies imaging studies, and cooperative studies are being conducted. (KJD)
Date: January 1, 1982
Creator: Mettler, F.A. Jr.
Partner: UNT Libraries Government Documents Department
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Development of Bromine-77 from the LAMPF facility

Description: The objective of the work is to conduct the necessary studies required to evaluate the efficacy, potential benefit and role of bromine-77 labelled steroids in the detection and evaluation of treatment for hormone-dependent tumors. The synthetic goals of 1982-3 included the synthesis estradiol derivatives which were radiohalogenated in the A- or C-ring with bromine-77 or bromine-82. Estradiol derivatives in which the radiohalogen was incorporated into the C-ring were prepared and purified with h… more
Date: December 3, 1982
Creator: Mettler, F.A. & Hylarides, M.
Partner: UNT Libraries Government Documents Department
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Interactive radiopharmaceutical facility between Yale Medical Center and Brookhaven National Laboratory. Progress report, June 1981-July 1982

Description: Progress is reported in the following research areas: (1) evaluation of /sup 14/C-labelled carboxyethyl ester 2-cardoxy methyl ester of arachidonic acid; (2) the effects of drug intervention on cardiac inflammatory response following experimental myocardial infarction using indium-111 labeled autologous leukoyctes; (3) the evaluation of /sup 97/Ru-oxine to label human platelets in autologous plasma; and (4) the specific in vitro radiolabeling of human neutrophils. (ACR)
Date: January 1, 1982
Creator: Gottschalk, A.
Partner: UNT Libraries Government Documents Department
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Development of advanced technologies for photochemical tritium recovery. Bi-quarterly progress report, July 1, 1981-December 31, 1981. [From heavy water]

Description: A process to photochemically remove tritium from heavy water has been described previously. Order-of-magnitude cost estimates for this process have been made, based on the specifications, assumptions, and parameters. The estimated costs of each unit and of the complete system are given. The total capital cost (excluding laser cost) of $650,000 corresponds to a cost of $0.08/Ci tritium removed, for plant amortization over one year. The electrical load is about 154 kW; this is equal to a cost of … more
Date: February 3, 1982
Creator: Aldridge, F. T.; Herman, I. P.; Magnotta, F. & Marling, J. B.
Partner: UNT Libraries Government Documents Department
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Metabolic changes associated with shoot formation in tobacco callus cultures

Description: Callus tissue derived from Nicotiana tabacum L. stem pith parenchyma cells was grown either on medium which maintains the callus in an undifferentiated state, or on medium which induces the formation of shoots. Two complementary types of studies were performed with the goal of establishing metabolic markers for the initiation of shoot formation: one designed to characterize the flow of radioactive sucrose into various metabolic pools, and one which allowed measurement of intermediary metabolite… more
Date: August 1, 1982
Creator: Grady, Karen Lee
Partner: UNT Libraries Government Documents Department
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Regional glucose metabolism using PETT in normal and psychiatric populations

Description: The metabolism of /sup 18/F-2-deoxy-2-fluoro-D-glucose (/sup 18/FDG) in 150 subjects including normals, schizophrenics, senile dementias, and primary affective disorders was studied. Some of the data analyzed to date are discussed.
Date: January 1, 1982
Creator: Brodie, J.D.; Wolf, A.P. & Volkow, N.
Partner: UNT Libraries Government Documents Department
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Inertial fusion: an energy-production option for the future

Description: The authors discuss the inertial-confinement approach to fusion energy. After explaining the fundamentals of fusion, they describe the state of the art of fusion experiments, emphasizing the results achieved through the use of neodymium-doped glass lasers at Lawrence Livermore National Laboratory and at other laboratories. They highlight recent experimental results confirming theoretical predictions that short-wavelength lasers have excellent energy absorption on fuel pellets. Compressions of d… more
Date: May 1, 1982
Creator: Hovingh, Jack; Pitts, John H.; Monsler, Michael J. & Grow, Gerald R.
Partner: UNT Libraries Government Documents Department
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Preparation and characterization of tritium targets. [Titanium tritide]

Description: The Isotope Research Materials Laboratory (IRML) of the Oak Ridge National Laboratory (ORNL) prepares tritium targets that are used to produce an intense beam of 14.5 MeV neutrons by the /sup 3/H(/sup 2/H,/sup 1/n)/sup 4/He reaction. The intense beams of 14.5 MeV neutrons are used in programs involving cancer research, materials evaluation, and materials identification. The tritium targets required by researchers have ranged in size from 1-cm diam to 50-cm diam and have contained from 3.7 x 10/… more
Date: January 1, 1982
Creator: Ramey, D. W. & Adair, H. L.
Partner: UNT Libraries Government Documents Department
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Mechanical properties of vapor-deposited thin metallic films: a status report

Description: The mechanical properties of vapor-deposited thin metallic films are being studied in conjunction with the target fabrication group associated with the laser-fusion energy program. The purpose of the work is to gain an understanding as to which metals are structurally best suited to contain a glass microsphere filled with deuterium-tritium (D-T) gas at large internal pressures.
Date: December 17, 1982
Creator: Adler, Paul H.
Partner: UNT Libraries Government Documents Department
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