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The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion

Description: The human breast comprises three lineages: the luminal epithelial lineage, the myoepithelial lineage, and the mesenchymal lineage. It has been widely accepted that human breast neoplasia pertains only to the luminal epithelial lineage. In recent years, however, evidence has accumulated that neoplastic breast epithelial cells may be substantially more plastic in their differentiation repertoire than previously anticipated. Thus, along with an increasing availability of markers for the myoepithel… more
Date: May 12, 2001
Creator: Petersen, Ole William; Nielsen, Helga Lind; Gudjonsson, Thorarinn; Villadsen, René Ronnov-Jessen, Lone & Bissell, Mina J.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Development of Cu-64 labeled EGF for In Vivo PET Imaging of EGFR Expression

Description: In this project we proposed to establish feasibility of the development of targeted tracers for radionuclide imaging of epidermal growth factor receptors (EGFR) in cancer patients. The significance and impact of the proposed radiotracers are determined by the crucial role that EGFR plays in many cancers and by the rapid entrance of EGFR-inhibiting drugs into clinic. Clinical experience, however, revealed that only 10-25% of patients that are defined as EGFR-positive by immunohistochemical analy… more
Date: July 12, 2009
Creator: Backer, Joseph M.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Examination of Genetic Alterations in Preneoplastic and Neoplastic Lesions of the Lung From Uranium Miners. Final Technical Report

Description: Lung cancer is one of the leading causes of death in the United States and in Western Europe. The incidence of lung cancer in developing countries is rising as their cigarette smoking habits increase. The objectives of this proposed research are to analyze genetic alterations associated with the development and progression on non-small cell lung carcinoma (MSCLC). Endpoints that may be realized from this proposed research are: (1) detection of early genetic and/or cellular alterations which ult… more
Date: July 12, 2000
Creator: Anderson, Marshall
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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