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Low-exposure tritium radiotoxicity in mammals

Description: Studies of tritium radiotoxicity involving chronic /sup 3/H0H exposures in mammals demonstrate in both mice and monkeys that biological effects can be measured following remarkably low levels of exposure - levels in the range of serious practical interest to radiation protection. These studies demonstrate also that deleterious effects of /sup 3/H beta radiation do not differ significantly from those of gamma radiation at high exposures. In contrast, however, at low exposures tritium is signific… more
Date: February 11, 1982
Creator: Dobson, R.L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Cytometry of mammalian sperm

Description: Male germ cells respond dramatically to a variety of insults and are important reproductive dosimeters. Semen analyses are very useful in studies on the effects of drugs, chemicals, and environmental hazards on testicular function, male fertility and heritable germinal mutations. The accessibility of male cells makes them well suited for analytical cytology. We might automate the process of determining sperm morphology but should not do so solely for increased speed. Rather, richer tangible ben… more
Date: October 11, 1983
Creator: Gledhill, B.L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Mode-of-Action Uncertainty for Dual-Mode Carcinogens: A Bounding Approach for Naphthalene-Induced Nasal Tumors in Rats Based on PBPK and 2-Stage Stochastic Cancer Risk Models

Description: A relatively simple, quantitative approach is proposed to address a specific, important gap in the appr approach recommended by the USEPA Guidelines for Cancer Risk Assessment to oach address uncertainty in carcinogenic mode of action of certain chemicals when risk is extrapolated from bioassay data. These Guidelines recognize that some chemical carcinogens may have a site-specific mode of action (MOA) that is dual, involving mutation in addition to cell-killing induced hyperplasia. Although ge… more
Date: May 11, 2007
Creator: Bogen, K T
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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