Mechanisms Involved in Trichloroethylene-Induced Liver Cancer: Importance to Environmental Cleanup
Description:
The project is organized around two interrelated tasks: Task 1 develops the basic dosimetry parameters and provides in vivo data describing the mode of action tumorigenic and for the metabolites of TCE that produce liver cancer in mice, dichloroacetate (DCA) and trichloroacetate (TCA). Early work suggested that TCA was primarily responsible for TCE-induced liver tumor. More recent, mechanistic observations indicated that DCA played a prominent role. Therefore, studies were designed to determineā¦
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Date:
June 1, 2000
Creator:
Bull, Richard J. & Thrall, Brian D.
Item Type:
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Partner:
UNT Libraries Government Documents Department