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Kinetics of reversible-sequestration of leukocytes by the isolated perfused rat lung

Description: The kinetics and morphology of sequestration and margination of rat leukocytes were studied using an isolated perfused and ventilated rat lung preparation. Whole rat blood, bone marrow suspension, or leukocyte suspensions, were used to perfuse the isolated rat lung. The lung was also perfused with latex particle suspensions and the passage of particles through the lung capillaries was studied. When a leukocyte suspension was perfused through the lung in the single-pass mode, the rate of sequest… more
Date: August 1, 1980
Creator: Goliaei, B.
Partner: UNT Libraries Government Documents Department
open access

Human data demonstrating extra long retention of plutonium in the lung

Description: Case histories are presented of 10 humans with inhalation depositions of Pu in which the Pu is retained in the lung or pulmonary lymph system for extremely long periods. The retention half-times range from 5000 to at least 20,000 d for most (in some cases all) of the initial deposition. In no case was a clearance half-time in the hundreds of days observed. The form of Pu involved in these cases is believed to be calcined Pu oxide. 9 refs., 1 fig., 2 tabs.
Date: January 1, 1991
Creator: Bihl, D.E.; Carbaugh, E.H. & Sula, M.J.
Partner: UNT Libraries Government Documents Department
open access

Comparison of two lung clearance models based on the dissolution rates of oxidized depleted uranium

Description: An in-vitro dissolution study was conducted on two respirable oxidized depleted uranium samples. The dissolution rates generated from this study were then utilized in the International Commission on Radiological Protection Task Group lung clearance model and a lung clearance model proposed by Cuddihy. Predictions from both models based on the dissolution rates of the amount of oxidized depleted uranium that would be cleared to blood from the pulmonary region following an inhalation exposure wer… more
Date: October 1, 1984
Creator: Crist, K. C.
Partner: UNT Libraries Government Documents Department
open access

Solubility classification of airborne products from uranium ores and tailings piles. [Solubility parameters are based on airborne and seived ground dust samples]

Description: Airborne products generated at uranium mills were assigned solubility classifications for use in the ICRP Task Group Lung Model. No significant difference was seen between the dissolution behavior of airborne samples and sieved ground samples of the same product. If the product contained radionuclides that dissolved at different rates, composite classifications were assigned to show the solubility class of each component. If the dissolution data indicated that a radionuclide was present in two … more
Date: January 1, 1979
Creator: Kalkwarf, D. R.
Partner: UNT Libraries Government Documents Department
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Lung-clearance classification of radionuclides in calcined phosphate rock dust

Description: Lung-clearance classifications for /sup 210/Pb and /sup 210/Po in airborne dust from elemental phosphorus plants were estimated for use with the lung clearance model proposed by the ICRP Task Group on Lung Dynamics. Estimates were based on measurements of dissolution rates for these radionuclides from sized dust samples into simulated lung fluid at 37/sup 0/C. The estimates were expressed in the classification terms of the model, i.e., D, W and Y, indicating lung clearance half-times of 0 to 10… more
Date: August 1, 1984
Creator: Kalkwarf, D. R. & Jackson, P. O.
Partner: UNT Libraries Government Documents Department
open access

Report of work performed by Dr. Ivancica Trosic in response to procurement request No. 4478H University of California, Los Alamos National Laboratory, Los Alamos, New Mexico

Description: Rats were intratracheally instilled with polystyrene microspheres and/or asbestos particles (0.5 mg) suspended in PBS. Six animals from each group were dispatched n days 1, 7, 30, 80 and 150 days after their respective instillations. Their lungs were lavaged, and quantifications of lavaged fluorescent microspheres, analyses of distributions of microspheres in lung, phagocytes by type, quantification of unlavaged lung burdens of microspheres, and quantification of tracheobronchial lymph mode bur… more
Date: July 1, 1994
Creator: Trosic, I.
Partner: UNT Libraries Government Documents Department
open access

A linear, time-varying simulation of the respiratory tract system

Description: These results show that regional deposition efficiencies of inhaled particles are highly dependent on the level of physical activity in all the spectrum of thermodynamic and aerodynamic aerosol particle sizes; also it was shown that for particles in the aerodynamic size range, the values of regional deposition efficiencies at the inner regions of the lung are highly dependent on age. In addition, the shape of regional deposition efficiency curves as a function of particle size have a similar be… more
Date: November 1, 1992
Creator: Hernandez, O.
Partner: UNT Libraries Government Documents Department
open access

Workshop on Dosimetry for Radon and Radon Daughters

Description: Emphasis is placed on the dosimetry for radon and daughters, rather than on monitoring and instrumentation. The objectives of the meeting were to exchange scientific information, to identify problem areas in radon-daughter dosimetry, and to make any observations or recommendations by the participants through issuance of this report. The discussion topics included the history of dosimetry for radon and daughters, human data, aerosols, deposition and movement in the respiratory tract, dose calcul… more
Date: May 1, 1978
Creator: Turner, J. E.; Holoway, C. F. & Loebl, A. S.
Partner: UNT Libraries Government Documents Department
open access

Environmental and health effects review for obscurant graphite flakes. Final report, 1991 July--1993 May

Description: The health and environmental effects of obscurant graphite flakes were reviewed and compared to predicted levels of graphite flake material in the field during typical testing and training scenarios. Graphite flake dispersion and deposition for simulated mechanical and pyrotechnic releases were determined using a modified Gaussian atmospheric plume-dispersion model. The potential for wind resuspension of graphite flakes is controlled by weathering processes and incorporation rates in soil. Chem… more
Date: July 1, 1993
Creator: Driver, C. J.; Ligotke, M. W.; Landis, W. G.; Downs, J. L.; Tiller, B. L.; Moore, E. B. Jr. et al.
Partner: UNT Libraries Government Documents Department
open access

Methods to improve routine bioassay monitoring for freshly separated, poorly transported plutonium

Description: Several human cases involving inhalation of plutonium oxide at Hanford have shown clearance half-times from the lung that are much longer than the 500-day half-time recommended for class Y plutonium in Publication 30 of the International Commission on Radiological Protection(ICRP). The more tenaciously retained material is referred to as super class Y plutonium. The ability to detect super class Y plutonium by current routine bioassay measurements is shown to be poor. Pacific Northwest Laborato… more
Date: September 1, 1988
Creator: Bihl, D. E.; Lynch, T. P.; Carbaugh, E. H. & Sula, M. J.
Partner: UNT Libraries Government Documents Department
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