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in subjects: "Iodouracils"  
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Potential radiosensitizing antiviral and anticancer pyrimidine nucleosides. Final report, June 1, 1974--May 31, 1978

Description: The synthesis of a variety of novel nucleosides as potential antiviral, antineoplastic, and radiation sensitizing agents was investigated. The most significant accomplishment of this period was the development of 5-Iodo-5'-amino-2',5'-dideoxyuridine (AIU, AIdUrd) which is the first compound to require unequivocally, for antiviral activity, a unique activation by an enzyme (thymidine kinase) encoded by the Herpes virus genome. This unusual requirement for activation prevents toxicity to uninfect… more
Date: September 1, 1978
Creator: Prusoff, W.H.
Partner: UNT Libraries Government Documents Department
open access

Kinetic and biochemical studies on tumor growth. Final report, October 1, 1967--July 14, 1976. [X radiation, /sup 125/I tracer technique]

Description: The normal growth kinetics and the recovery kinetics following therapeutic perturbations with drugs and x-irradiation for the mouse duodenal crypt cells and the S102F and slow line tumor cells have been studied in depth, the rationale being that a detailed understanding of these phenomena would enhance our knowledge about tumor biology per se and also expand our appreciation of how normal and malignant tissues respond to and recover from therapeutic insults. Hopefully, such knowledge will event… more
Date: unknown
Creator: Dethlefsen, L. A.
Partner: UNT Libraries Government Documents Department
open access

Potential radiosensitizing antiviral and anticancer pyrimidine nucleosides. Technical progress report, June 1, 1975--December 22, 1975. [UV radiation]

Description: A newly developed method of synthesis now affords the large scale production of 5'-amino analogs of a variety of nucleosides. This procedure has been used to synthesize the 5'-amino analog of 5-iodo-, 5-bromo-, 5-chloro-, 5-fluoro-, 5-trifluoromethyl-2',5'-dideoxyuridine. In addition to the previously established antiviral activity of 5-iodo-5'-amino-2',5'-dideoxyuridine (AIU), we have found 5-bromo- (ABrU) and 5-iodo-5'-amino-2',5'-dideoxycytidine (AIC) to be even more potent antiviral agents … more
Date: January 1, 1976
Creator: Prusoff, W. H.
Partner: UNT Libraries Government Documents Department
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