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High-LET radiation carcinogenesis

Description: The dose-response curves for the induction of tumors by high-LET radiation are complex and are insufficiently understood. There is no model or formulation to describe the dose-response relationship over a range 0 to 100 rad. Evidence suggests that at doses below 20 rad the response is linear, at least for life shortening and some tumor systems. Thus, limiting values of RBEs for the induction of cancer in various tissues can be determined, but it will require sufficient data obtained at low sing… more
Date: January 1, 1985
Creator: Fry, R.J.M.; Powers-Risius, P.; Alpen, E.L. & Ainsworth, E.J.
Partner: UNT Libraries Government Documents Department
open access

High-let radiation carcinogenesis

Description: Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heav… more
Date: January 1, 1982
Creator: Fry, R.J.M.; Powers-Risius, P.; Alpen, E.L.; Ainsworth, E.J. & Ullrich, R.L.
Partner: UNT Libraries Government Documents Department
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