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Harvard-MIT research program in short-lived radiopharmaceuticals

Description: This report presents research on radiopharmaceuticals. The following topics are discussed: antibody labeling with positron-emitting radionuclides; antibody modification for radioimmune imaging; labeling antibodies; evaluation of technetium acetlyacetonates as potential cerebral blood flow agents; and studies in technetium chemistry. (CBS)
Date: January 1, 1991
Creator: Adelstein, S.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A Phase 1 biodistribution study of p-boronophenylalanine

Description: The objectives of the Phase I BPA biodistribution study are as follows: Objective 1: To establish the safety of orally administered boronophenylalanine (BPA) as determined by monitoring of patient's vital signs and by clinical analysis of blood before and after BPA administration. Objective 2: To establish BPA pharmacokinetics by monitoring the rates of boron absorption into and clearance from the blood and the rate of urinary excretion of boron. Objective 3: To measure the amount of boron inco… more
Date: January 1, 1991
Creator: Coderre, J.A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Metastasis

Description: Distant metastasis of primary neoplasms is the main factor that limits the success of antineoplastic therapy. It can be regarded as an early or late event in the neoplastic process, and varies considerably with tumor type. The metastatic potential of a given tumor greatly influences prognosis. Tumor metastasis is not a single neoplastic event, rather, it involves several major steps: invasion of cells from the primary tumor into tissue, and penetration of blood and lymph vessels; release of tum… more
Date: October 1, 1991
Creator: Weller, R. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Health effects models for nuclear power plant accident consequence analysis: Modifications of models resulting from recent reports on health effects of ionizing radiation

Description: The Nuclear Regulatory Commission has sponsored several studies to identify and quantify the potential health effects of accidental releases of radionuclides from nuclear power plants. The most recent health effects models resulting from these efforts were published in two reports, NUREG/CR-4214, Rev. 1, Part 1 (1990) and Part 2 (1989). Several major health effects reports have been published recently that may impact the health effects models presented in these reports. This addendum to the Par… more
Date: August 1, 1991
Creator: Abrahamson, S.; Bender, M. A.; Boecker, B. B.; Scott, B. R. & Gilbert, E. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Comparison of the effects of inhaled {sup 239}PuO{sub 2} and {beta}- emitting radionuclides on the incidence of lung carcinomas in laboratory animals

Description: The health effects of inhaling radioactive particles when the lung is the primary organ irradiated were studied in rats and Beagle dogs. The animals were exposed to aerosols of {sup 239}PuO{sub 2} or fission-product radionuclides in insoluble forms and observed for their life span. Lung carcinomas were the primary late-occuring effect. The incidence rate for lung carcinomas was modeled using a proportional hazard rate model. Linear functions predominated below 5 Gy to the lung. The life-time ri… more
Date: December 31, 1991
Creator: Hahn, F. F.; Griffith, W. C.; Boecker, B. B.; Muggenburg, B. A. & Lundgren, D. L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

A Phase 1 biodistribution study of p-boronophenylalanine

Description: The objectives of the Phase I BPA biodistribution study are as follows: Objective 1: To establish the safety of orally administered boronophenylalanine (BPA) as determined by monitoring of patient`s vital signs and by clinical analysis of blood before and after BPA administration. Objective 2: To establish BPA pharmacokinetics by monitoring the rates of boron absorption into and clearance from the blood and the rate of urinary excretion of boron. Objective 3: To measure the amount of boron inco… more
Date: December 31, 1991
Creator: Coderre, J. A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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