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Development and Characterization of Compliant Bioelectronic Devices for Gastrointestinal Stimulation

Description: In this research, we aimed to develop thin-film devices on a polymer substrate and an alternative 3D-printed device with macroelectrodes for treating gastrointestinal (GI) conditions. First, the fabrication of thin-film devices was demonstrated on a softening thiol-ene/acrylate polymer utilizing titanium nitride (TiN) as electrode material. This was achieved by utilizing cleanroom fabrication processes such as photolithography, wet and dry etching. The functionality of the device was shown by p… more
This item is restricted from view until January 1, 2026.
Date: December 2023
Creator: Chitrakar, Chandani

Development of Biomimetic Human Lung Alveolus Chip

Description: The potential of physiologically relevant in vitro cell culture models for studying physiological and pathophysiological phenomena has been widely recognized as replacements for animal and conventional in vitro models. To create models that accurately replicate the structure and function of tissues and organs, it is essential to comprehend the biophysical and mechanical features of the extracellular matrix (ECM) and incorporate them into the in vitro cell culture models. Therefore, we first aim… more
Date: May 2023
Creator: Man, Kun

Engineering a Microfluidic Blood-Brain Barrier on a Silicon Chip

Description: The blood-brain barrier (BBB) is composed of brain microvascular endothelial cells (BMECs), pericytes, and astrocytic endfeet, which regulate the transport of molecules into and out of the brain. BMECs possess intrinsic barrier properties that limit the passage of approximately 98% of small molecules into the brain in healthy individuals. However, in some brain diseases, the BBB undergoes structural and functional alterations, which can contribute to disease progression. In this study, we aimed… more
Date: July 2023
Creator: Liu, Jiafeng

Human Cerebral Organoids in Pillar/Perfusion Plates for Modeling Neurodevelopmental Disorders

Description: Human induced pluripotent stem cell (iPSCs)-derived brain organoids have potential to recapitulate the earliest stages of brain development, serving as an effective in vitro model for studying both normal brain development and disorders. In this study, we demonstrate a straightforward approach of generating multiple cerebral organoids from iPSCs on a pillar plate platform, eliminating the need for labor-intensive, multiple transfer and encapsulation steps to ensure the reproducible generation o… more
This item is restricted from view until June 1, 2025.
Date: May 2024
Creator: Acharya, Prabha

Pillar/Perfusion Plates for Miniature Human Tissue Culture and Predictive Compound Screening

Description: Human organoids have potential to revolutionize in vitro disease modeling by providing multicellular architecture and functional that are similar to those in vivo. Nonetheless, organoid-based, high-throughput screening (HTS) of compounds is challenged by lack of easy-to-use fluidic systems that are compatible with relatively large organoids. Therefore, we first fabricated a pillar plate, which was coupled with a complementary deep well plate and a perfusion well plate for static and dynamic cul… more
This item is restricted from view until December 1, 2024.
Date: May 2024
Creator: Kang, Sooyeon
open access

Thermo-Reversible Phase-Change Actuators for Physical Human-Robot Interactions

Description: Exploring the advancement of soft and variable impedance actuators (VIAs), the research focuses on their potential for enhancing safety and adaptability in physical human-robot interactions (pHRI). Despite the promising attributes of these technologies, their adoption in portable applications is still emerging. Addressing the challenges hindering the widespread implementation of soft actuators and VIAs, a multidisciplinary approach is employed, spanning materials science, chemistry, thermodynam… more
Date: May 2024
Creator: Exley, Trevor Wayne
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