Modulation of ³H-Myo-Inositol Uptake by Glucose and Sorbitol in Cultured Bovine Lens Epithelial Cells
Description:
Myo-[3H]-inositol accumulation in cultured bovine lens epithelial cells (BLECs) occurred by both high- and low affinity, Nat-dependent transport sites. High ambient glucose significantly inhibited myo-[ 3 H]-inositol uptake; the co-administration of sorbinil, an aldose reductase inhibitor, prevented the inhibitory effect on the low affinity transport site. A glucose-sensitive process for myo-[3 H]-inositol uptake on the high-affinity transport site was uncovered by Lineweaver-Burk analysis. Dix…
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Date:
August 1992
Creator:
Chen, Hai-Qing
Partner:
UNT Libraries