Selective Photothermolysis to target Sebaceous Glands: Theoretical Estimation of Parameters and Preliminary Results Using a Free Electron Laser Metadata

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Title

  • Main Title Selective Photothermolysis to target Sebaceous Glands: Theoretical Estimation of Parameters and Preliminary Results Using a Free Electron Laser

Creator

  • Author: Fernanda Sakamoto, Apostolos Doukas, William Farinelli, Zeina Tannous, Michelle D. Shinn, Stephen Benson, Gwyn P. Williams, H. Dylla, Richard Anderson
    Creator Type: Personal

Contributor

  • Sponsor: United States. Department of Energy. Office of Science.
    Contributor Type: Organization
    Contributor Info: USDOE Office of Science (SC)

Publisher

  • Name: Thomas Jefferson National Accelerator Facility (U.S.)
    Place of Publication: Newport News, Virginia
    Additional Info: Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

Date

  • Creation: 2011-12-01

Language

  • English

Description

  • Content Description: The success of permanent laser hair removal suggests that selective photothermolysis (SP) of sebaceous glands, another part of hair follicles, may also have merit. About 30% of sebum consists of fats with copious CH2 bond content. SP was studied in vitro, using free electron laser (FEL) pulses at an infrared CH2 vibrational absorption wavelength band. Absorption spectra of natural and artificially prepared sebum were measured from 200 nm to 3000 nm, to determine wavelengths potentially able to target sebaceous glands. The Jefferson National Accelerator superconducting FEL was used to measure photothermal excitation of aqueous gels, artificial sebum, pig skin, human scalp and forehead skin (sebaceous sites). In vitro skin samples were exposed to FEL pulses from 1620 to 1720 nm, spot diameter 7-9.5 mm with exposure through a cold 4C sapphire window in contact with the skin. Exposed and control tissue samples were stained using H and E, and nitroblue tetrazolium chloride staining (NBTC) was used to detect thermal denaturation. Natural and artificial sebum both had absorption peaks near 1210, 1728, 1760, 2306 and 2346 nm. Laser-induced heating of artificial sebum was approximately twice that of water at 1710 and 1720 nm, and about 1.5x higher in human sebaceous glands than in water. Thermal camera imaging showed transient focal heating near sebaceous hair follicles. Histologically, skin samples exposed to {approx}1700 nm, {approx}100-125 ms pulses showed evidence of selective thermal damage to sebaceous glands. Sebaceous glands were positive for NBTC staining, without evidence of selective loss in samples exposed to the laser. Epidermis was undamaged in all samples. Conclusions: SP of sebaceous glands appears to be feasible. Potentially, optical pulses at {approx}1720 nm or {approx}1210 nm delivered with large beam diameter and appropriate skin cooling in approximately 0.1 s may provide an alternative treatment for acne.
  • Physical Description: 175

Subject

  • Keyword: Removal
  • Keyword: Heating
  • Keyword: Cameras
  • Keyword: Chlorides
  • Keyword: Wavelengths
  • Keyword: Excitation
  • Keyword: Absorption
  • STI Subject Categories: 59 Basic Biological Sciences
  • Keyword: Absorption Spectra
  • Keyword: Targets
  • Keyword: Hair
  • Keyword: Glands
  • Keyword: In Vitro
  • Keyword: Transients
  • Keyword: Free Electron Lasers
  • Keyword: Skin
  • Keyword: Lasers
  • Keyword: Hair Follicles
  • Keyword: Epidermis
  • STI Subject Categories: 60 Applied Life Sciences
  • Keyword: Tetrazolium

Source

  • Journal Name: Lasers in Surgery and Medicine; Journal Volume: 44; Journal Issue: 2

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Article

Format

  • Text

Identifier

  • Report No.: JLAB-FEL-11-1430
  • Report No.: DOE/OR/23177-1835
  • Grant Number: AC05-06OR23177
  • DOI: 10.1002/lsm.21132
  • Office of Scientific & Technical Information Report Number: 1039896
  • Archival Resource Key: ark:/67531/metadc845167
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