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Table S2. Observed Mass-to-Charge Ratios for [Ln"'(3,4,3-LI(1,2-HOPO))] complexes at pH 7.4.'
Metal Species m/z
La [La"'(3,4,3-LI(1,2-HOPO))] 885
Pr [Pr"'(3,4,3-LI(1,2-HOPO))] 887
Nd [Nd"'(3,4,3-LI(1,2-HOPO))] 890
Sm [Sm"'(3,4,3-LI(1,2-HOPO))] 898
Eu [Eu"(3,4,3-LI(1,2-HOPO))] 899
Gd [Gd"'(3,4,3-LI(1,2-HOPO))] 904
Tb [Tb"'(3,4,3-LI(1,2-HOPO))] 905
Dy [Dy"'(3,4,3-LI(1,2-HOPO))] 910
Ho [Ho"'(3,4,3-LI(1,2-HOPO))] 911
Er [Er"'(3,4,3-LI(1,2-HOPO))] 914
Tm [Tm"'(3,4,3-LI(1,2-HOPO))] 915
Yb [Yb"i(3,4,3-LI(1,2-HOPO))] 920
Lu [Lu"(3,4,3-LI(1,2-HOPO))] 921
a[3,4,3-LI(1,2-HOPO)] = 0.5 mM [Ln"'] = 0.05 mM, no buffer added.
bReported numbers correspond to the main peaks in each spectrum.
Table S3. Promotion of 1Eu Excretion in Mice by Injected Octadentate Ligands.a
Fraction of injected 152Eu (%, mean + SD) at 24 h
Tissues Excreta
Ligand Liver Skeleton Soft tissue Kidneys Whole body Feces Urine
Control 30.7 + 1.93 28.9 + 1.25 6.29 + 0.90 1.0 + 0.22 67.0 + 1.21 2.19 30.8
DTPA 22.0 0.90 25.9 2.17 4.94 0.27 0.78 0.09 53.7 1.78 8.71 37.6
3,4,3-LI(1,2-HOPO) 1.24 + 0.22 12.8 + 0.47 3.12 + 0.31 0.44 + 0.10 17.6 + 0.71 52.6 29.8
io 'Groups of five mice were injected intravenously with '52Eu; mice were injected intraperitoneally with 30 iimol/kg of a
ligand at 1 h; control mice were given 0.14 M NaCl (normal saline) intraperitoneally; mice were euthanized at 24 h. Data,
expressed as percent of injected '52Eu (%, mean SD), were normalized to 100% material recovery for each five-mouse
group. Discrepancies are due to rounding. SD = [I dev2 (n-1)1]112; for tissues, n = number of mice.
bExcreta of each five-mouse group were pooled; no SD is available.
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Table S4. In Vivo Stability of Intraperitoneally Injected 1Eu Complexes.'
Fraction of injected 152Eu (%, mean + SD) at 24 h
Tissues Excretab
Ligand Liver Skeleton Soft tissue Kidneys Whole body Feces Urine
DTPA 0.09 0.02 0.07 0.05 0.22 0.11 0.11 +0.025 0.49 0.12 10.1 89.4
3,4,3-LI(1,2-HOPO) 0.05 0.03 0.02 0.03 0.10 0.04 0.022 0.004 0.20 0.07 89.3 10.5
'Groups of five mice were injected intraperitoneally with '52Eu-ligand complexes; 5 iimol/kg of ligand; ligand:Eu molar
20 ratio > 20; mice were euthanized at 24 h. Data, expressed as percent of injected '52Eu (%, mean SD), were normalized to
100% material recovery for each five-mouse group. Discrepancies are due to rounding. SD = [i dev2 (n-1)1]112; for tissues,
n = number of mice.
bExcreta of each five-mouse group were pooled; no SD is available.