The Possibility of Branch Conformation in Azotobacter Vinelandii Chromosomal DNA Carrying Multiple Gene Copies and Its Folded State in the Cell Page: 8
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structural details as seen in "weak" segments of DNA. The structure
of azotobacter DNA has been examined previously in several
published papers (33, 47, 49) but unambiguous results have not been
reported nor has an explanation been tendered that would reconcile
the possibility of a chromosome with both haploid and polyploid
domains been proposed.
Three possibilities of chromosomal DNA conformation that
would explain observed data were investigated. One model proposed
is a single, very large, double-stranded circular DNA in which many
genes appear in tandem but others in single copy. Another pos-
sibility is based on a hypothetical structure such as that shown in
Figure 1. A third possibility was considered in which the whole
single chromosome was composed of sub-circular members of DNA
connected by branching segments in which one double-stranded DNA
molecule branched out to give two or three double-stranded DNA
molecules. The nif genes and any other easily mutated genes were
located on a circular member as a single copy and the rest of the
genes located on the other circular segments, one copy per each
member DNA semi circular element. In this case, however, a sig-
nificant problem in chromosomal DNA replication could be expected.
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Choi, Munhyeong. The Possibility of Branch Conformation in Azotobacter Vinelandii Chromosomal DNA Carrying Multiple Gene Copies and Its Folded State in the Cell, thesis or dissertation, August 1991; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc798271/m1/14/: accessed July 18, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .