Radiation Effects Research Foundation five year strategic research plan and program management, 1997-2001 Page: 88 of 152
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3730 on analysis of these data has been made in recent years, there is a need to devote more of
3731 the departmental resources to the issues related to the clinical data. An area of particular
3732 importance over the next few years concerns studies that integrate the epidemiological and
3733 clinical data related to the finding of an association between radiation exposure and
3734 noncancer mortality. These analyses will undoubtedly lead to challenging statistical
3735 problems.
3736
3737 A-3 Analyses of Laboratory Data
3738
3739 The investigations carried out by the. staff of the Departments of Genetics and
3740 Radiobiology often require statistical collaboration for planning and analysis. At the
3741 present time statisticians are actively involved in comprehensive final analyses of the
3742 conventional chromosome aberration data, assessment of the data on various somatic
3743 mutation assays, and the provision of advice and support for a broad range of fairly
3744 routine statistical analyses carried out by the researchers in the laboratories. Analyses of
3745 the laboratory data present a number of challenging statistical problems including issues
3746 related to over-dispersion (due to dosimetry error or unmeasured covariates) and
3747 correlated data. Over the next few years there will be a need for significant additional
3748 statistical support for the analyses of the 2-DE DNA study data (pattern recognition), for
3749 the planning and analysis of molecular epidemiological studies, and for work on the
3750 comparison of various potential biodosimeters.
3751
3752 A-4 Database development
3753
3754 The Department of Statistics has taken a leading role in the design and documentation of
3755 the new RERF research database. While the ITD is responsible for the actual
3756 implementation of the database, much of the design work involves issues of direct concern
3757 to the Department of Statistics. These issues include clarification of study population
3758 definitions, specification of contents of and relationships between individual database
3759 tables, and the identification of appropriate data sources, and, in some cases, the
3760 development of new coding schemes for specific items. At the present time the RERF
3761 research database includes most of the epidemiological follow-up data and basic dosimetry
3762 data for the major cohorts. Current efforts are focused primarily on the integration of the
3763 mail survey, clinical follow-up data, laboratory data and detailed dosimetric data
3764 (including shielding history and acute effects data), into the RERF research database.
3765
3766 A-5 Dosimetry (Work on dosimetry is covered by RP 18-59, Shielding Survey and
3767 Dosimetry Study.)
3768
3769 The Department of Statistics is responsible for management of the basic dosimetry data
3770 and for the computation of dose estimates for individual survivors. Current work includes
3771 the development of an expanded roster of persons whose exposure status is of interest to
3772 RERF (in addition to LSS cohort members, this roster includes mothers of in-utero cohort
3773 members and parents of F, cohort members) and the restructuring of the shielding history
3774 and acute effects data. As a part of this effort we are also working on an updated
3775 description of cohort definitions and dose estimation procedures. In the decade since the
3776 introduction of DS86 a number of questions have been raised about certain aspects of81
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Radiation Effects Research Foundation five year strategic research plan and program management, 1997-2001, report, October 31, 1997; Washington D.C.. (https://digital.library.unt.edu/ark:/67531/metadc716813/m1/88/: accessed July 16, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.