Radiation Effects Research Foundation five year strategic research plan and program management, 1997-2001 Page: 12 of 152
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166 continuing evaluation of the research program be made, future directions determined or revised
167 as need arises, and research priorities established. This strategic research plan has been developed
168 to achieve these ends.
169
170 To carry out its responsibilities in an orderly and scientifically sound manner and to be
171 responsive to its charter, the broad goals of the Foundation are:
172
173 * To determine the late health effects, both somatic and genetic, produced in human beings
174 from exposure to ionizing radiation.
175
176 * To obtain information on the temporal pattern of cancer expression and other radiation-
177 related effects and on the role of biological and environmental factors which may modify
178 the effects resulting from exposure to ionizing radiation.
179
180 The strategy for addressing these goals is implicit in the following general research
181 objectives:
182
183 * To conduct long-term epidemiological studies of a fixed sample of exposed and
184 unexposed individuals to determine the frequency-dose relationships of morbidity and
185 mortality resulting from radiation exposure and to obtain information on the differential
186 sensitivity of various tissues.
187
188 * To conduct case-control and other special investigations on cancer induced in specific
189 tissues or organs to determine the cell types affected and the effects of modifying factors.
190
191 * To conduct research in molecular and cellular biology to detect somatic mutation, cell
192 transformation, changes in immunological competence and other biological events for use
193 in understanding and estimating radiation risk.
194
195 " To utilize all available sensitive and cost-effective approaches for measuring heritable
196 mutation in the children of exposed and unexposed individuals, and for assessing the
197 public health impact of these mutations.
198
199 All research at the Foundation aimed at these goals takes place under published research
200 protocols that must obtain the approval of the Chief of Research, the Research Protocol
201 Committee, the Human Investigation Committee, and the Chairman of the Foundation before they
202 are activated. These protocols are of two kinds, the so-called platform protocols that guide the
203 major or core research activities of the Foundation, and special research protocols. The core
204 activities commonly involve more than one department and are collaborative; whereas the specific
205 research activities may or may not be collaborative. A listing of the currently active protocols will
206 be found in Annex L Of primary importance to the Foundation are, of course, the core activities
207 since ultimately they are the raison d'etre of the institution.
208
209 RESEARCH PROGRAM STRATEGY
210
211 To conduct a successful long-term epidemiological investigation which addresses the goals
212 of RERF, data must be collected on a continuing, prospective basis using specified samples of5
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Radiation Effects Research Foundation five year strategic research plan and program management, 1997-2001, report, October 31, 1997; Washington D.C.. (https://digital.library.unt.edu/ark:/67531/metadc716813/m1/12/: accessed July 16, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.