Neuropharmacological Characteristics of Tolerance for Cocaine Used as a Discriminative Stimulus

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The main purpose of this research was to investigate the phenomenon of tolerance to cocaine. Tolerance is operationally defined as a decreased drug effect due to prior history of drug administration. The animal model that was chosen to investigate tolerance to cocaine was the drug discrimination model, which is an animal analogue of human subjective drug effects. In the drug discrimination procedure, animals are trained to emit one behavior when injected with saline. In the present experiments, rats were trained to press one lever when injected with cocaine, 10 mg/kg, and a different lever when injected with saline for food … continued below

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vii, 156 leaves: ill.

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Wood, Douglas M. (Douglas Michael) August 1987.

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  • Wood, Douglas M. (Douglas Michael)

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The main purpose of this research was to investigate the phenomenon of tolerance to cocaine. Tolerance is operationally defined as a decreased drug effect due to prior history of drug administration. The animal model that was chosen to investigate tolerance to cocaine was the drug discrimination model, which is an animal analogue of human subjective drug effects. In the drug discrimination procedure, animals are trained to emit one behavior when injected with saline. In the present experiments, rats were trained to press one lever when injected with cocaine, 10 mg/kg, and a different lever when injected with saline for food reinforcement. Once rats are trained, they can accurately detect the cocaine stimulus greater than 95% of the time.

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vii, 156 leaves: ill.

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  • August 1987

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Wood, Douglas M. (Douglas Michael). Neuropharmacological Characteristics of Tolerance for Cocaine Used as a Discriminative Stimulus, dissertation, August 1987; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc331725/: accessed July 17, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .

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