Analysis of a Human Transfer RNA Gene Cluster and Characterization of the Transcription Unit and Two Processed Pseudogenes of Chimpanzee Triosephosphate Isomerase Page: 77

                                
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Fig. 8. Comparison of the chimpanzee solitary long
terminal repeat (LTR) in the A,V|fchpTPI-B pseudogene with the
LTR sequences from the human endogenous retrovirus gene HERV-
K10 (Ono, 1986; Ono et al., 1986; GenBank accession number
HUMERVKA). Dashes in the human LTR DNA sequences indicate a
match with the chimpanzee LTR DNA sequence, and mismatched
bases are given in lower-case letters, with the exception of
residue 2 96 in the human 3'-LTR sequence, which is A instead
of G. The cellular direct repeat sequence (AGACTG) is boxed
only at the LTR 3'-terminus, since the 5'-terminal direct
repeat is a part of the defective coding region in X.\|/chpTPI-
B shown in Fig. 2. The LTR U3, R, and U5 segments are
indicated by arrows (Temin, 1981; Chen and Barker, 1984;
Ono, 1986). The imperfect inverted terminal repeats TGTGGGG
and CCCCTACA start at 1 and 961, respectively. Other
interesting features (boxed) include: a variant
glucocorticoid response element, GGAGACTCCATTTTGTTCT,
starting at residue 62 (Yamamoto, 1985), a SV40 core
enhancer element, TGGAATGT, starting at 518 (Khoury and
Gruss, 1983), a TATA promoter element (TATAAAA, starting at
531), a presumptive polyadenylation signal (AATAAA, starting
at 7 93), and a putative polyadenylation site (CA, residues
812-813).