Cancer increase study methodology: A review and discussion of the ``Southeastern Massachusetts Health Study 1978--1986`` Page: 37 of 43
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1992) or between 200 and 300 person-rem from our estimates. Based on BEIR V
risk estimates, this would be expected to cause a total of from 0 to 0.05
cancer deaths.
Leukemia is more frequent in males than females. The case population of-
the SMHS included 64 males and 41 females. In an earlier study in 1982-84,
myelogenous leukemia was elevated in males and females but only the male risk
was statistically significant. Thus, in the present study. why did females
exhibit a stronger association than males? According to the MDPH
investigators, the male-female difference in high-exposure category was
probably not due to chance: the p value for the sex-exposure interaction term
was 0.07. What would explain sex-specific risks? The finding are opposite to
what would be expected on the basis of leukemia risks reported in BEIR V and
indicates potential for sex-specific confounders. According to BEIR V. the
risk of leukemia following radiation exposure is higher for males than for
females. The estimate of excess leukemia mortality per 100,000 males per 10
rem exposure is 110 cases whereas for a comparable population and exposure for
females, the estimate is 80 cases (National Research Council 1990). The sex
ratio was 1.5 males:1 female which is similar to population incidence. Also,
as noted, in the earlier study only male risk was significantly elevated. Is
it possible that exposure scores for females are based more highly on
residence than are males' scores? Are there differences in terms of location
of employment? Do women tend to work nearer their residence than males?A.15
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Sever, L. E.; Baker, D. A.; Gilbert, E. S. & Mahaffey, J. A. Cancer increase study methodology: A review and discussion of the ``Southeastern Massachusetts Health Study 1978--1986``, report, September 1, 1993; Richland, Washington. (https://digital.library.unt.edu/ark:/67531/metadc1399643/m1/37/: accessed July 16, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.