Investigation on the Pulmonary Effects of Intermetallic Beryllium Compounds. Final Report, January 1, 1976-December 31, 1978 Page: 11 of 30
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6
Beryllium caused a greater response in the number of pulmonary
macrophages in the alveoli. These cells contained dark black-gray
granules. The terminal and respiratory bronchioles exhibited slight
to moderate infiltration by lymphocytes. No fibrosis or epithelial
hyperplasia was seen at 30 days of sacrifice. At 60 and 90 days the
accumulation of macrophages had decreased. Fibrosis of the terminal
bronchioles was moderate.
After tantalum beryllide, there was fibrosis of the respiratory
bronchioles of a slight degree at 30 days. This was increased after
60 and 90 days. Also, slight hyperplasia of the epithelium in the
terminal bronchioles was present. This was not seen in any of the
other groups. The response by pulmonary macrophages was minimal.
The niobium and copper beryllide exhibited an infiltration by
lymphocytes in the respiratory bronchioles. There was a moderate
number of pulmonary macrophages. These contained gray granular
material. At 90 days sacrifice, some macrophages with the granular
material were still present.
The. rats on the long-term experiment were treated with penicillin
and tetracycline prophylactically two days before and ten days after
the intratracheal intubation of the materials. During the course of
18 months the morbidity and mortality was greater than expected. In
Table 2 the mortality data are summarized.
According to the experimental design (Table 1) 5 rats had been
added as a precaution in case the mortality would be high. Unfor-
tunately, the number of survivors was lower than the anticipated one,
namely, 20 rats per group at 18 months. Only two animals in the
2.5 mg beryllium metal group exhibited a pulmonary carcinoma in the
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Stemmer, K. L. Investigation on the Pulmonary Effects of Intermetallic Beryllium Compounds. Final Report, January 1, 1976-December 31, 1978, report, Date Unknown; Cincinnati, Ohio. (https://digital.library.unt.edu/ark:/67531/metadc1094889/m1/11/: accessed July 16, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.