The Acute Toxic Effects of the Synthetic Cannabinoid, JWH-018 on the Cardiovascular and Neuroendocrine Systems in Ictalurus punctatus (Channel Catfish) Page: I
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Taylor, Dedric E. The Acute Toxic Effects of the Synthetic Cannabinoid, JWH-
018 on the Cardiovascular and Neuroendocrine Systems in Ictalurus punctatus
(Channel Catfish). Doctor of Philosophy (Biology), August 2017, 93 pp., 3 tables, 16
figures, references, 187 titles.
Cannabinoid (CB) receptors have been found in most vertebrates that have been
studied. The location of various CB receptors in the body and brain are known, but their
physiological functions are not fully understood. The effects CBs have on the
cardiovascular system have been of growing interest in recent years. Increasing reports
from emergency departments and law enforcement agencies detail acute
cardiovascular and psychological effects from synthetic CB intoxication, such as JWH-
018. This major health concern is substantiated by governmental agencies like the CDC
and NIDA. This pilot study investigates the acute toxic effects of the synthetic CB, JWH-
018, on the cardiovascular and neuroendocrine systems in Ictalurus punctatus (channel
catfish). Research in organisms besides the traditional mammal models can provide
new insights into CB function and physiology. Ictalurus punctatus lend multiple benefits
as a model organism that permits researchers to investigate in vivo effects of both
cardiovascular and neuroendocrine systems without much influence from traditional
sampling methods, and further more provide ample size and tissue to perform specific
cardiovascular experiments. Multiple methods were used to assess cardiovascular
function and sympathetic nervous system activation. Two different doses, low (500
pg/kg) and high 1,500 pg/kg, of JWH-018 were evaluated in the study. Delivery of JWH-
018, via dorsal aorta cannulation, was administered to channel catfish in order to
measure cardiovascular functions and sample blood. Plasma levels of the
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Taylor, Dedric Esmond. The Acute Toxic Effects of the Synthetic Cannabinoid, JWH-018 on the Cardiovascular and Neuroendocrine Systems in Ictalurus punctatus (Channel Catfish), dissertation, August 2017; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc1011766/m1/2/: accessed July 17, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .