Carbachol- and ACPD-Induced Phosphoinositide Responses in the Developing Rat Neocortex
Description:
Signal transduction via the phosphoinositide (PI) second messenger system has key roles in the development and plasticity of the neocortex. The present study localized PI responses to individual cortical layers in slices of developing rat somatosensory cortex. The acetylcholine agonist carbachol and the glutamate agonist trans-1-amino-1,3-cyclopentanedicarboxylic acid (ACPD) were used to stimulate PI turnover. The PI responses were compared to the distribution of the corresponding PI-linked rec…
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Date:
August 2000
Creator:
Hartgraves, Morri D.