Design of New Monodentate Ligands for Regioselectivity and Enantioselectivity Tuning in Late Transition Metal Catalysis
Description:
The ability of gold(I) to activate many types of unsaturated bonds toward nucleophilic attack was not widely recognized until the early 2000s. One major challenge in gold catalysis is the control over regioselectivity when there are two or more possible products as a result of complicated mechanistic pathways. It is well know that the choice of ligand can have dramatic effects on which pathway is being followed but very rarely are the reasons for this selectivity understood. The synthesis of n…
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Date:
May 2016
Creator:
Ruch, Aaron A.