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UNIVERSITY
OF NORTH TEXASTM
Biocompatible
G raphene-based
Melissa Parks, Department of Chemi
Faculty Mentor: Diane Verrill, Department of
I
3rk In Pro.
stry, College of Ai
Political Science, Coil
Research Project: Cellular growth via graphene sheets
Research Question: Can viable cancer cells be grown on graphene
sheets in a setting outside the body to effectively mimic common
cancers acting within the body?
Graphene, discovered in 2004 by Konstantin Novoselov and
Andrew Geim, is a transparent nanomaterial made of a single layer of
carbon atoms in a hexagonal pattern. Its high conductivity makes it a
useful addition to micro-transistors such as in cell phones.
Pure graphene is made of solely carbon atoms in a hexagonal
double-bonded ring making it much stronger than its counterpart
graphene oxide (GO). GO is a graphene sheet that is bonded with
oxygen and oxygen groups. The extra atoms break the carbon-carbon
double bonds making the sheets much less conductive and more prone
to divergences of shape. Both graphene and graphene oxide sheets
have been used to study cellular growth and differentiation with
success.
Based on the properties of both, the broken bonds of GO allow for
better adhesion to the sheet and substrate, but the solid bonds of
graphene allow for more electrical conductivity and therefore more
differentiation.
TOPIC
BACKGROUND
Since this experiment will be very similar to the process of grow
graphene oxide films, many of the methods I have left unchanged
however, several things will be taken into account such as the nu
manage to grow), the time and growing conditions, and the states
rw4L I
3 IImoI
Graphene has recently been discovered to be useful in disassocia
into neurons and glial cells (1). Its biocompatibility is advantage(
pharmaceutical industries. The process to create this differentiati,
of graphene which was placed in a laminin solution to help the st
was successful because the cells differentiated based on growth f
periodically over a long period of time.
Also successfully created, Mesenchymel stem cells from bon
three cell extractions (adipocytes, osteoblasts, and chondrocytes)
company coated human bone marrow MSCs onto graphene and
unusual patterns of differentiation were observed. Also observed
occurred faster, which led to the hypothesis that interactions with
those used could in fact differentiate into other lineages as well (
method of preparation and execution.
The use of graphene oxide films can be used in Retinal Pigm,
neurological subject matter. The graphene oxide sheets allow for
the cells to grow (3). It is possible that large cell groups can be hfR
In Liu and company's experiment, the biocompatibility of RPE c
examined. Details concerning the morphology, spectroscopy, aml
were collected and it was conceived that graphene oxide films cc
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