Effect of Ethanol on Galactose Tolerance in Man
Description
Galactose-/sup 13/C was given to 18 subjects; /sup 13/CO/sub 2/ excretion in respiratory air was followed for 3 hours. Each subject was given galactose-/sup 13/C/sub 6/ (10 g/m/sup 2/), then retested some days later with the same amount of labeled sugar and a low level (3.5 g/m/sup 2/) of ethanol. On the basis of the /sup 13/CO/sub 2/ excretion curves in the presence and absence of ethanol, the subjects were divided into four groups (i.e., subjects considered as normal, probably normal, probable liver damage, and liver damage). Ethanol strongly inhibited galactose metabolism in normal subjects. This effect of ethanol progressively … continued below
Physical Description
20 p.
Creation Information
Gregg, C. T.; Rudnick, J.; McInteer, B. B.; Whaley, T. W. & Shreeve, W. W. January 1, 1978.
Context
This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by the UNT Libraries Government Documents Department to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 48 times. More information about this article can be viewed below.
Who
People and organizations associated with either the creation of this article or its content.
Publisher
-
Los Alamos Scientific Laboratory
Publisher Info: Los Alamos Scientific Lab., N.Mex. (USA)Place of Publication: New Mexico
Provided By
UNT Libraries Government Documents Department
Serving as both a federal and a state depository library, the UNT Libraries Government Documents Department maintains millions of items in a variety of formats. The department is a member of the FDLP Content Partnerships Program and an Affiliated Archive of the National Archives.
Contact Us
What
Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.
Description
Galactose-/sup 13/C was given to 18 subjects; /sup 13/CO/sub 2/ excretion in respiratory air was followed for 3 hours. Each subject was given galactose-/sup 13/C/sub 6/ (10 g/m/sup 2/), then retested some days later with the same amount of labeled sugar and a low level (3.5 g/m/sup 2/) of ethanol. On the basis of the /sup 13/CO/sub 2/ excretion curves in the presence and absence of ethanol, the subjects were divided into four groups (i.e., subjects considered as normal, probably normal, probable liver damage, and liver damage). Ethanol strongly inhibited galactose metabolism in normal subjects. This effect of ethanol progressively declined in the four groups until, in the last group (liver damage), ethanol had no further effect on the already severely depressed oxidation of galactose. Comparison of the galactose tolerance data with other clinical tests and with the results of a drinking history suggests that the ethanol-primed galactose tolerance test may give good discrimination between groups of people with varying degrees of liver damage short of frank cirrhosis, although alcohol-priming is not necessary to distinguish between normal and cirrhotic subjects.
Physical Description
20 p.
Notes
Dep. NTIS, PC A02/MF A01.
Subjects
Keywords
- Alcohols
- Animals
- Biological Effects
- Carbohydrates
- Carbon 13
- Carbon Compounds
- Carbon Dioxide
- Carbon Oxides
- Chalcogenides
- Clearance
- Diagnosis
- Digestive System
- Digestive System Diseases
- Even-Odd Nuclei
- Excretion
- Exhalation
- Galactose
- Hexoses
- Hydroxy Compounds
- Isotope Applications
- Isotopes
- Light Nuclei
- Metabolism
- Monosaccharides
- Nuclei
- Organs
- Oxygen Compounds
- Pathological Changes
- Saccharides
- Stable Isotopes
- Tracer Techniques
- Vertebrates 550501* -- Metabolism-- Tracer Techniques
- aldehydes
- bodies
- carbon isotopes
- diseases
- ethanol
- glands
- humans
- labelled compounds
- liver functions
- mammals
- organic compounds
- oxides
- primates
STI Subject Categories
- 550601 -- Medicine-- Unsealed Radionuclides In Diagnostics
- 550901 -- Pathology-- Tracer Techniques
- 551001 -- Physiological Systems-- Tracer Techniques
- 560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
- 59 Basic Biological Sciences
- 62 Radiology And Nuclear Medicine
- 63 Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.
Source
- 3. international conference on stable isotopes, Oak Brook, IL, USA, 23 May 1978
Language
Item Type
Identifier
Unique identifying numbers for this article in the Digital Library or other systems.
- Report No.: LA-UR-78-1416
- Report No.: CONF-780501-3
- Grant Number: W-7405-ENG-36
- Office of Scientific & Technical Information Report Number: 6850379
- Archival Resource Key: ark:/67531/metadc1196095
Collections
This article is part of the following collection of related materials.
Office of Scientific & Technical Information Technical Reports
Reports, articles and other documents harvested from the Office of Scientific and Technical Information.
Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.
Digital Files
When
Dates and time periods associated with this article.
Creation Date
- January 1, 1978
Added to The UNT Digital Library
- July 2, 2018, 10:52 p.m.
Description Last Updated
- March 8, 2019, 7:01 p.m.
Usage Statistics
When was this article last used?
Interact With This Article
Here are some suggestions for what to do next.
Start Reading
Citations, Rights, Re-Use
International Image Interoperability Framework
We support the IIIF Presentation API
Print / Share
Links for Robots
Helpful links in machine-readable formats.
Archival Resource Key (ARK)
- ERC Record: /ark:/67531/metadc1196095/?
- Persistence Statement: /ark:/67531/metadc1196095/??
International Image Interoperability Framework (IIIF)
- IIIF Manifest: /ark:/67531/metadc1196095/manifest/
Metadata Formats
- UNTL Format: /ark:/67531/metadc1196095/metadata.untl.xml
- DC RDF: /ark:/67531/metadc1196095/metadata.dc.rdf
- DC XML: /ark:/67531/metadc1196095/metadata.dc.xml
- OAI_DC: /oai/?verb=GetRecord&metadataPrefix=oai_dc&identifier=info:ark/67531/metadc1196095
- METS: /ark:/67531/metadc1196095/metadata.mets.xml
- OpenSearch Document: /ark:/67531/metadc1196095/opensearch.xml
Images
- Thumbnail: /ark:/67531/metadc1196095/thumbnail/
- Small Image: /ark:/67531/metadc1196095/small/
URLs
- In-text: /ark:/67531/metadc1196095/urls.txt
Stats
- Usage Stats: /stats/stats.json?ark=ark:/67531/metadc1196095
Gregg, C. T.; Rudnick, J.; McInteer, B. B.; Whaley, T. W. & Shreeve, W. W. Effect of Ethanol on Galactose Tolerance in Man, article, January 1, 1978; New Mexico. (https://digital.library.unt.edu/ark:/67531/metadc1196095/: accessed May 3, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.