Search Results

Safety of Continuous Infusion Ketorolac in Postoperative Coronary Artery Bypass Graft Surgery Patients

Description: This article evaluates the safety of continuous infusion ketorolac which is sometimes utilized for analgesia in postoperative coronary artery bypass graft (CABG) patients. This retrospective cohort study evaluated the primary outcome of mortality and secondary outcomes of incidence of bleeding and myocardial infarction (MI). No association was found between continuous infusion ketorolac and increased risk of mortality, MI, or bleeding events in postoperative CABG patients.
Date: June 28, 2016
Creator: Howard, Meredith L.; Warhurst, Robert D. & Sheehan, Courtney
Partner: UNT Health Science Center

Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody

Description: This article examines the feasibility of encapsulating monoclonal antibodies within poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a water/oil/water double emulsion solvent evaporation technique. This method can be used to prepare protective polymeric nanoparticles for transporting functional antibodies to the cytoplasmic compartment of cancer cells. The author's studies achieved successful formulation of antibody loaded polymeric nanoparticles, thus indicating that a PLGA-based antibody nanoformulation is a promising intracellular delivery vehicle for a large number of new intracellular antibody targets in cancer cells.
Date: February 12, 2015
Creator: Gdowski, Andrew; Ranjan, Amalendu; Mukerjee, Anindita & Vishwanatha, Jamboor
Partner: UNT Health Science Center

Regulation of Autophagy by Kinases

Description: This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets.
Date: June 9, 2011
Creator: Sridharan, Savitha; Jain, Kirti & Basu, Alakananda
Partner: UNT Health Science Center

Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research

Description: This review aims to find effective phytoconstituents in cataract treatments in vitro, ex vivo, and in vivo. Scientists have focused their attention not only for anti-cataract activity in vitro, but also in ex vivo and in vivo from the review of active phytoconstituents in medicinal plants. In our present review, we identified 58 active phytoconstituents with strong anti-cataract effects at in vitro and ex vivo with lack of in vivo studies.
Date: October 26, 2018
Creator: Lim, Vuanghao; Schneider, Edward; Wu, Hongli & Pang, Iok-Hou
Partner: UNT Health Science Center

Association of Home Food Availability with Prediabetes and Diabetes among Adults in the United States

Description: This article examined associations of home food availabilities with prediabetes and diabetes among 8929 adults (20–70 years) participating in 2007–2010 National Health and Nutrition Examination Surveys. The results show prediabetes participants had lower availability of healthy foods and higher availability of unhealthy foods, suggesting the need to improve healthy food availability at home for this population.
Date: April 25, 2020
Creator: McAtee, Jenniffer; Tao, Meng-Hua; King, Christian & Chai, Weiwen
Partner: UNT Health Science Center

Aircraft-Assisted Pilot Suicides in the General Aviation Increased for One-Year Period after 11 September 2001 Attack in the United States

Description: The article describes a study that evaluated the possible effect the 11 September 2001, terrorist attacks had on pilot AASs in the U.S. Fatal aviation accidents in the National Transportation Safety Board (NTSB) database were searched using the following search words: “suicide”, “murder-suicide” and “homicide-suicide”. The timeline between 11 September 1996, and 11 September 2004, was analyzed. This study showed an association, albeit not determinate causal effect, of a very specific series of simultaneous terrorist murder-suicides with subsequent pilot AASs.
Date: November 12, 2018
Creator: Vuorio, Alpo; Laukkala, Tanja; Junttila, Ilkka; Bor, Robert; Budowle, Bruce; Pukkala, Eero et al.
Partner: UNT Health Science Center

Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

Description: This article is an overview the interplay between HIV-1 viral and cellular proteins for restrictions/competitions for proliferation of the virus in the infected cell, which could open a new avenue for the development of therapeutics against HIV-1 via targeting a specific step of the proteasome degradation pathway during the HIV-1 life cycle.
Date: June 19, 2019
Creator: Rojas, Vivian K. & Park, In-Woo
Partner: UNT Health Science Center

Peripheral Circulating Exosomal miRNAs Potentially Contribute to the Regulation of Molecular Signaling Networks in Aging

Description: This article aims to understand some of the causes of aging and the underlying mechanisms that may lead to interventions that could reverse certain aging processes and slow development of aging-related diseases. People are living longer than ever. Consequently, they have a greater chance for developing a functional impairment or aging-related disease, such as a neurodegenerative disease, later in life.
Date: March 11, 2020
Creator: Zhang, Hongxia & Jin, Kunlin
Partner: UNT Health Science Center

Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications

Description: This review highlights recent studies and progress involved in understanding the development of cutaneous melanocytes and the regulation of McSCs. Melanocytes in the skin play an indispensable role in the pigmentation of skin and its appendages. It is well known that the embryonic origin of melanocytes is neural crest cells. In adult skin, functional melanocytes are continuously repopulated by the differentiation of melanocyte stem cells (McSCs) residing in the epidermis of the skin.
Date: December 21, 2015
Creator: Mull, Amber N.; Zolekar, Ashwini & Wang, Yu-Chieh
Partner: UNT Health Science Center

The Implications of Cancer Stem Cells for Cancer Therapy

Description: This review summarizes the characteristics, evidences and development of CSCs, as well as implications and challenges for cancer treatment. Surgery, radiotherapy and chemotherapy are universally recognized as the most effective anti-cancer therapies. Recent studies have showed that cancer stem cells (CSCs), a small subpopulation of tumor cells, can generate bulk populations of nontumorigenic cancer cell progeny through the self-renewal and differentiation processes.
Date: December 5, 2012
Creator: Jiang, Wenjing; Peng, Jianhua; Zhang, Yue; Cho, William C. S. & Jin, Kunlin
Partner: UNT Health Science Center

Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract

Description: The article describes a study that tested and confirmed the hypothesis that TRPA1 expressed in the primary sensory afferents may modulate the function of second order NTS neurons. The expression of TRPA1 was detected in presynaptic locations, but not the somata of caudal NTS neurons that did not express TRPA1 mRNA or proteins. Moreover, caudal NTS neurons did not show somatodendritic responsiveness to TRPA1 agonists, while TRPA1 immunostaining was detected only in the afferent fibers.
Date: April 26, 2019
Creator: Feng, Lin; Uteshev, Victor V. & Premkumar, Louis S.
Partner: UNT Health Science Center

Flanking Variation Influences Rates of Stutter in Simple Repeats

Description: This article shows that rates of stutter can vary substantially depending on the flanking haplotype, and while there are cases where the LUS is a better predictor of stutter than the PAL, examples to the contrary are apparent in commonly assayed forensic markers. Further, flanking variation that is 7 bp from the repeat region can impact rates of stutter. These findings suggest that non-proximal effects, such as DNA secondary structure, may be impacting the rates of stutter in common forensic short tandem repeat markers.
Date: November 17, 2017
Creator: Woerner, August E.; King, Jonathan L. & Budowle, Bruce
Partner: UNT Health Science Center

Transitioning from Acute to Chronic Pain: An Examination of Different Trajectories of Low-Back Pain

Description: The article examines the most recent trajectory research, and highlights the importance of developing a broader model for patient evaluation. Traditionally, there has been a widely accepted notion that the transition from acute to chronic pain follows a linear trajectory, where an injury leads to acute episodes, subacute stages, and progresses to a chronic pain condition. However, it appears that pain progression is much more complicated and individualized than this original unsupported assumption.
Date: May 17, 2018
Creator: Gatchel, Robert J.; Bevers, Kelley; Licciardone, John C.; Su, Jianzhong; Du, Ying & Brotto, Marco
Partner: UNT Health Science Center

The Impact of the 2002 Delaware Smoking Ordinance on Heart Attack and Asthma

Description: This article analyzes the Delaware Hospital Discharge Database, and identified state and non-state residents discharged with AMI or asthma for the years 1999 to 2004. Statistical data analysis compared the incidence of AMI or asthma for each group before (1999–2002) and after (2003–2004) the amendment. As a result, the authors found that pre-ordinance and post-ordinance quarterly rates of AMI for Delaware residents were 451 (se = 21) and 430 (se = 21) respectively, representing a 4.7% reduction.
Date: December 2, 2010
Creator: Moraros, John; Bird, Yelena; Chen, Shande; Buckingham, Robert; Meltzer, Richard S.; Prapasiri, Surasri et al.
Partner: UNT Health Science Center

The Potential Role of Nanotechnology in Therapeutic Approaches for Triple Negative Breast Cancer

Description: This review is focused on opportunities for developing new approaches for filling the current void in an effective treatment for Triple Negative Breast Cancer, TNBC, patients. Triple Negative Breast Cancer, TNBC, a highly aggressive and metastatic type of breast cancer, is characterized by loss of expression of the estrogen receptor (ER), progesterone receptor (PR), and a lack of overexpression of the human epidermal growth factor receptor 2 (HER2).
Date: June 18, 2013
Creator: Johnson, Rebecca; Sabnis, Nirupama; McConathy, Walter J. & Lacko, Andras G.
Partner: UNT Health Science Center

The Enigmatic Protein Kinase C-eta

Description: The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death.
Date: February 13, 2019
Creator: Basu, Alakananda
Partner: UNT Health Science Center

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

Description: The article is part of a series of Editorials published biannually that highlights a number of recently published articles that describe crucial findings.
Date: June 30, 2019
Creator: Mangoni, Arduino A; Vanden Eynde, Jean Jacques; Jampilek, Josef; Hadjipavlou-Litina, Dimitra; Liu, Hong; Reynisson, Jóhannes et al.
Partner: UNT Health Science Center

Treatment and Prevention of Recurrent Clostridium difficile Infection with Functionalized Bovine Antibody-Enriched Whey in a Hamster Primary Infection Model

Description: This article focuses on the development of an alternative drug for the treatment of Clostridium difficile infection (CDI). Oral administration of anti-CD-WPI is a functional therapy of CDI in infected hamsters for both primary treatment and prevention of recurrence. Thus, anti-CD-WPI could address the urgent unmet medical need for treating and preventing recurrent CDI in humans.
Date: February 6, 2019
Creator: Heidebrecht, Hans-Jürgen; Weiss, William J.; Pulse, Mark; Lange, Anton; Gisch, Karina; Kliem, Heike et al.
Partner: UNT Health Science Center

Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms

Description: This review attempts to provide integrated information at the levels of oxidative signaling mechanisms by which ethanol withdrawal (EW) provokes brain injuries and 17β-estradiol (E2) protects against it. Unmanaged sudden withdrawal from the excessive consumption of alcohol (ethanol) adversely alters neuronal integrity in vulnerable brain regions such as the cerebellum, hippocampus, or cortex.
Date: July 20, 2010
Creator: Jung, Marianna E. & Metzger, Daniel B.
Partner: UNT Health Science Center

Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress

Description: This article investigates if chronic inhibition of DLDH could also attenuate oxidative stress in type 2 diabetes. It is the authors' belief that DLDH inhibition could be a novel approach to fighting type 2 diabetes.
Date: February 2, 2019
Creator: Yang, Xiaojuan; Song, Jing & Yan, Liang-Jun
Partner: UNT Health Science Center