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open access

Thymus Functionality Needs More Than a Few TECs

Description: Article is a review exploring the contributions of the many stromal cell types participating in the formation, expansion, and contraction of the thymus under normal and pathophysiological processes. Such information will better inform approaches for restoring thymus functionality, including thymus organoid technologies, beneficial when an individuals’ own tissue is congenitally, clinically, or accidentally rendered non-functional.
Date: June 10, 2022
Creator: Bhalla, Pratibha; Su, Dong-Ming & van Oers, Nicolai S. C.
Partner: UNT Health Science Center
open access

Traditional Chinese Medicine and Western Medicine Share Similar Philosophical Approaches to Fight COVID-19

Description: This article is a commentary exploring the disciplines of Western medicine and Traditional Chinese Medicine's philosophical methods to fight COVID-19 to understand their philosophical theories that could achieve the maximum benefits for treatment of COVID-19 and other diseases.
Date: August 1, 2021
Creator: Zhao, Fangfang; Yang, Zhenhong; Wang, Ningqun; Jin, Kunlin & Luo, Yumin
Partner: UNT Health Science Center
open access

Protein Modification by ADP-ribose via Acid-labile Linkages

Description: Article describing the preparation and chemical characterization of low molecular weight conjugates that were used as models for an acetal linkage between ADP-ribose and the hydroxyl group of a protein acceptor such as serine, threonine, tyrosine, hydroxyproline, or hydroxylysine residues. The amount of modification was approximately 16 pmol of ADP-ribose per mg of total protein, and proteins modified by acid-labile linkages were detected in all subcellular fractions examined, suggesting that t… more
Date: April 7, 1995
Creator: Cervantes-Laurean, Daniel; Loflin, Paul T.; Minter, David E.; Jacobson, Elaine L. & Jacobson, Myron K.
Partner: UNT Health Science Center
open access

NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner

Description: This article's study endeavors to determine if p53 is responsible for cisplatin sensitization by NSC109268. Results have implications for sensitivity of ovarian cancer cells to cisplatin independent of p53.
Date: October 5, 2010
Creator: Shankar, Eswar; Basu, Chandreyi; Adkins, Brett; Siede, Wolfram & Basu, Alakananda
Partner: UNT Health Science Center
open access

Sarcoidosis and Its Splenic Wonder: A Rare Case of Isolated Splenic Sarcoidosis

Description: This article is a case study discussing a case of a 40-year-old female with isolated splenic sarcoidosis found to have isolated splenomegaly with multiple hypodense splenic lesions and no other multisystem involvement. Isolated splenomegaly is very rare and an uncommon presentation of sarcoidosis. This case is clinically challenging because of the extensive differential diagnosis. The authors conclude that sarcoidosis of the spleen, although rare, should be considered in the differential diagno… more
Date: November 5, 2018
Creator: Jhaveri, Khushali & Surani, Salim R.
Partner: UNT Health Science Center
open access

Biodiversity of protists and nematodes in the wild nonhuman primate gut

Description: Article describes study which used an 18S rRNA gene fragment metabarcoding approach to assess the eukaryotic assemblage of 62 individuals representing 16 nonhuman primate NHP species to better understand the factors that influence the assembly and diversity of gut-associated eukaryotes.
Date: November 12, 2019
Creator: Mann, Allison E.; Mazel, Florent; Lemay, Matthew A.; Morien, Evan; Billy, Vincent; Kowalewski, Martin et al.
Partner: UNT Health Science Center
open access

Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms

Description: This review attempts to provide integrated information at the levels of oxidative signaling mechanisms by which ethanol withdrawal (EW) provokes brain injuries and 17β-estradiol (E2) protects against it. Unmanaged sudden withdrawal from the excessive consumption of alcohol (ethanol) adversely alters neuronal integrity in vulnerable brain regions such as the cerebellum, hippocampus, or cortex.
Date: July 20, 2010
Creator: Jung, Marianna E. & Metzger, Daniel B.
Partner: UNT Health Science Center
open access

Transitioning from Acute to Chronic Pain: An Examination of Different Trajectories of Low-Back Pain

Description: The article examines the most recent trajectory research, and highlights the importance of developing a broader model for patient evaluation. Traditionally, there has been a widely accepted notion that the transition from acute to chronic pain follows a linear trajectory, where an injury leads to acute episodes, subacute stages, and progresses to a chronic pain condition. However, it appears that pain progression is much more complicated and individualized than this original unsupported assumpt… more
Date: May 17, 2018
Creator: Gatchel, Robert J.; Bevers, Kelley; Licciardone, John C.; Su, Jianzhong; Du, Ying & Brotto, Marco
Partner: UNT Health Science Center
open access

Harnessing Data to Assess Equity of Care by Race, Ethnicity and Language

Description: Study examines disparities in healthcare based on race, ethnicity and language (REaL) by utilizing inpatient (IP) core measures at Texas Health Resources, a large, faith-based, non-profit healthcare system located in Texas.
Date: December 22, 2015
Creator: Gracia, Amber; Cheirif, Jorge; Veliz, Juana; Reyna, Melissa; Vecchio, Mara & Aryal, Subhash
Partner: UNT Health Science Center
open access

Aircraft-Assisted Pilot Suicides in the General Aviation Increased for One-Year Period after 11 September 2001 Attack in the United States

Description: The article describes a study that evaluated the possible effect the 11 September 2001, terrorist attacks had on pilot AASs in the U.S. Fatal aviation accidents in the National Transportation Safety Board (NTSB) database were searched using the following search words: “suicide”, “murder-suicide” and “homicide-suicide”. The timeline between 11 September 1996, and 11 September 2004, was analyzed. This study showed an association, albeit not determinate causal effect, of a very specific series of … more
Date: November 12, 2018
Creator: Vuorio, Alpo; Laukkala, Tanja; Junttila, Ilkka; Bor, Robert; Budowle, Bruce; Pukkala, Eero et al.
Partner: UNT Health Science Center
open access

“Youth Are More Aware and Intelligent than Imagined”: The Mountain Air Youth Photovoice Project

Description: This article looks at respiratory illness in Appalachian Kentucky because it reports some of the highest rates of respiratory illness in the United States. As part of the Mountain Air Project, local youth were invited to share their perspectives on possible contributing factors to respiratory illness, and the authors undertook an exploratory study to determine the utility of photovoice to elicit such perspectives with this population. This study demonstrates the value of incorporating youth per… more
Date: October 11, 2019
Creator: Cardarelli, Katheryn M.; Paul, Marcy; May, Beverly; Dunfee, Madeline; Browning, Steven & Schoenberg, Nancy
Partner: UNT Health Science Center
open access

Copycats in Pilot Aircraft-Assisted Suicides after the Germanwings Incident

Description: Paper describes studying aiming to evaluate changes in pilot aircraft-assisted suicide risks, i.e., a copycat effect, in the U.S. and Germany after the Germanwings 2015 incident in the French Alps.
Date: March 11, 2018
Creator: Laukkala, Tanja; Vuorio, Alpo; Bor, Robert; Budowle, Bruce; Navathe, Pooshan; Pukkala, Eero et al.
Partner: UNT Health Science Center
open access

The Impact of the 2002 Delaware Smoking Ordinance on Heart Attack and Asthma

Description: This article analyzes the Delaware Hospital Discharge Database, and identified state and non-state residents discharged with AMI or asthma for the years 1999 to 2004. Statistical data analysis compared the incidence of AMI or asthma for each group before (1999–2002) and after (2003–2004) the amendment. As a result, the authors found that pre-ordinance and post-ordinance quarterly rates of AMI for Delaware residents were 451 (se = 21) and 430 (se = 21) respectively, representing a 4.7% reduction. more
Date: December 2, 2010
Creator: Moraros, John; Bird, Yelena; Chen, Shande; Buckingham, Robert; Meltzer, Richard S.; Prapasiri, Surasri et al.
Partner: UNT Health Science Center
open access

The Implications of Cancer Stem Cells for Cancer Therapy

Description: This review summarizes the characteristics, evidences and development of CSCs, as well as implications and challenges for cancer treatment. Surgery, radiotherapy and chemotherapy are universally recognized as the most effective anti-cancer therapies. Recent studies have showed that cancer stem cells (CSCs), a small subpopulation of tumor cells, can generate bulk populations of nontumorigenic cancer cell progeny through the self-renewal and differentiation processes.
Date: December 5, 2012
Creator: Jiang, Wenjing; Peng, Jianhua; Zhang, Yue; Cho, William C. S. & Jin, Kunlin
Partner: UNT Health Science Center
open access

Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway

Description: This article highlights a study aimed to investigate neuroprotective mechanisms of HN. We analyzed intracellular Ca²+ levels, reactive oxygen species (ROS) production, and the MAPKs signal transduction cascade using an in vitro NMDA-mediated excitotoxicity of cortical neurons model.
Date: September 29, 2018
Creator: Yang, Xiaorong; Zhang, Hongmei; Wu, Jinzi; Yin, Litian; Yan, Liang-Jun & Zhang, Ce
Partner: UNT Health Science Center
open access

Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

Description: This article is an overview the interplay between HIV-1 viral and cellular proteins for restrictions/competitions for proliferation of the virus in the infected cell, which could open a new avenue for the development of therapeutics against HIV-1 via targeting a specific step of the proteasome degradation pathway during the HIV-1 life cycle.
Date: June 19, 2019
Creator: Rojas, Vivian K. & Park, In-Woo
Partner: UNT Health Science Center
open access

Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications

Description: This review highlights recent studies and progress involved in understanding the development of cutaneous melanocytes and the regulation of McSCs. Melanocytes in the skin play an indispensable role in the pigmentation of skin and its appendages. It is well known that the embryonic origin of melanocytes is neural crest cells. In adult skin, functional melanocytes are continuously repopulated by the differentiation of melanocyte stem cells (McSCs) residing in the epidermis of the skin.
Date: December 21, 2015
Creator: Mull, Amber N.; Zolekar, Ashwini & Wang, Yu-Chieh
Partner: UNT Health Science Center
open access

Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody

Description: This article examines the feasibility of encapsulating monoclonal antibodies within poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a water/oil/water double emulsion solvent evaporation technique. This method can be used to prepare protective polymeric nanoparticles for transporting functional antibodies to the cytoplasmic compartment of cancer cells. The author's studies achieved successful formulation of antibody loaded polymeric nanoparticles, thus indicating that a PLGA-based antib… more
Date: February 12, 2015
Creator: Gdowski, Andrew; Ranjan, Amalendu; Mukerjee, Anindita & Vishwanatha, Jamboor
Partner: UNT Health Science Center
open access

Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract

Description: The article describes a study that tested and confirmed the hypothesis that TRPA1 expressed in the primary sensory afferents may modulate the function of second order NTS neurons. The expression of TRPA1 was detected in presynaptic locations, but not the somata of caudal NTS neurons that did not express TRPA1 mRNA or proteins. Moreover, caudal NTS neurons did not show somatodendritic responsiveness to TRPA1 agonists, while TRPA1 immunostaining was detected only in the afferent fibers.
Date: April 26, 2019
Creator: Feng, Lin; Uteshev, Victor V. & Premkumar, Louis S.
Partner: UNT Health Science Center
open access

Salvianolic Acid B (Sal B) Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Cell Death by Activating Glutaredoxin 1 (Grx1)

Description: The article explores Salvianolic acid B (Sal B), a natural compound, as a Grx1 inducer, which potently protected retinal pigment epithelial (RPE) cells from oxidative injury. Their results showed that treatment with Sal B protected primary human RPE cells from H₂O₂-induced cell damage. They found Sal B pretreatment upregulated Grx1 expression in RPE cells in a time- and dose-dependent manner.
Date: November 3, 2016
Creator: Liu, Xiaobin; Xavier, Christy; Jann, Jamieson & Wu, Hongli
Partner: UNT Health Science Center
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