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Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor γ Activation Pathway in Gastric Cancer

Description: Article investigating the potential effects of isorhamnetin (IH), a 3′-O-methylated metabolite of quercetin on the peroxisome proliferator-activated receptor γ (PPAR-γ) signaling cascade using proteomics technology platform, GC cell lines, and xenograft mice model. The study y proposes a novel agent for gastric cancer treatment.
Date: November 2, 2012
Creator: Ramachandran, Lalitha; Manu, Kanjoormana Aryan; Shanmugam, Muthu K.; Li, Feng; Siveen, Kodappully Sivaraman; Vali, Shireen et al.
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Partner: UNT College of Science
open access

Cardiac and metabolic physiology of early larval zebrafish (Danio rerio) reflects parental swimming stamina

Description: This article explores swimming stamina in fish. Mature adult zebrafish (Danio rerio) were subjected to a swimming performance test and then bred within performance groups to discover if enhanced swimming stamina in offspring appears only in juveniles/adults, or if these traits appear as early as larvae.
Date: February 24, 2012
Creator: Burggren, Warren W. & Gore, Matthew
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Partner: UNT College of Science
open access

In situ cardiac performance of Atlantic cod (Gadus morhua) at cold temperatures: long-term acclimation, acute thermal challenge and the role of adrenaline

Description: This article measures the cardiac performance of Newfoundland Atlantic cod (Gadus morhua). The results: (1) show that maximum performance of the isolated cod heart is not compromised by exposure to cold temperatures; and (2) support data from other studies, which show that, in contrast to salmonids, cod cardiac performance/myocardial contractility is not dependent upon humoral adrenergic stimulation.
Date: November 15, 2012
Creator: Lurman, Glenn J. & Petersen, L. H.
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Partner: UNT College of Science
open access

Constraints-based stoichiometric analysis of hypoxic stress on steroidogenesis in fathead minnows, Pimephales promelas

Description: This article presents a study in which an in silico genome-scale metabolic model of steroidogenesis is used to investigate the effects of hypoxic stress on steroid hormone productions in fish. This article introduces a powerful model for pathway analysis that can lend insights on the effects of various stressor scenarios on metabolic functions.
Date: May 15, 2012
Creator: Hala, David; Petersen, Lene H.; Martinovic, Dalma & Huggett, Duane B.
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Partner: UNT Institute of Applied Sciences
open access

Upper lethal temperatures of Northern Bobwhite embryos and the thermal properties of their eggs

Description: This article explores the upper lethal temperature for Bobwhite eggs. Results find that thermal tolerances of Northern Bobwhite embryos are high, indicating an adaptation to the naturally occurring temperature extremes in the Bobwhite's environment. However, the results also indicate that high temperatures could have plausibly contributed to the population decline observed in the Bobwhite's semi-arid range.
Date: January 1, 2012
Creator: Reyna, Kelly S. & Burggren, Warren W.
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Partner: UNT College of Science
open access

Coprologic survey of endoparasites from Darwin’s fox (Pseudalopex fulvipes) in Chiloé, Chile

Description: Article on parasite presence in the critically endangered Darwin's fox (Pseudalopex fulvipes) in Chile. Parasites found include species and genera reported for the first time in Darwin's fox.
Date: January 1, 2012
Creator: Jiménez, Jaime E.; Briceño, C.; Alcaíno, H.; Vásquez, P.; Funk, S. & González-Acuña, D.
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Partner: UNT College of Science
open access

Metabolomics as a hypothesis-generating functional genomics tool for the annotation of Arabidopsis thaliana genes of “unknown function”

Description: Article describes the analysis of Arabidopsis metabolomics data sets acquired by a consortium that includes five analytical laboratories, bioinformaticists, and biostatisticians, which aims to develop and validate metabolomics as a hypothesis-generating functional genomics tool.
Date: February 10, 2012
Creator: Quanbeck, Stephanie M.; Brachova, Libuse; Campbell, Alexis A.; Guan, Xin; Perera, Ann; He, Kun et al.
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Partner: UNT College of Arts and Sciences
open access

Biochemical and molecular-genetic characterization of SFD1’s involvement in lipid metabolism and defense signaling

Description: Article describes study which sought to to determine if the dihydroxyacetone phosphate (DHAP) reductase activity and chloroplast localization are required for the Arabidopsis thaliana SFD1 (suppressor of fatty acid desaturase deficiency1) gene’s involvement in galactolipid metabolism and systemic acquired resistance (SAR) signaling.
Date: February 7, 2012
Creator: Lorenc-Kukula, Katarzyna; Chaturvedi, Ratnesh; Roth, Mary; Welti, Ruth & Shah, Jyoti
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Partner: UNT College of Arts and Sciences
open access

Cardiac and metabolic physiology of early larval zebrafish (Danio rerio) reflects parental swimming stamina

Description: Article describes experiment in which mature adult zebrafish (Danio rerio) were subjected to a swimming performance test that allowed separation into low swimming stamina or high swimming stamina groups in order to determine if inherited traits that support enhanced swimming stamina in offspring appear only in juveniles and/or adults, or if these traits actually appear earlier in the morphologically quite different larvae.
Date: February 24, 2012
Creator: Gore, Matthew & Burggren, Warren W.
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Partner: UNT College of Arts and Sciences
open access

Effect of selection for commercially productive traits on the plasticity of cardiovascular regulation in chicken breeds during embryonic development

Description: Article investigates basic cardiovascular physiology in the Red Junglefowl, the broiler, and the White Leghorn breeds at 90% of incubation. The authors aimed to identify breed-specific features of arterial blood pressure and heart rate as well as the physiological mechanisms regulating them. They concluded that selection for rapid growth shifts cardiovascular regulatory plasticity to emphasize mechanisms that modulate pressure, and that selection for egg-laying capacity emphasizes mechanisms th… more
Date: October 1, 2012
Creator: Crossley, Dane A., II & Altimiras, J.
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Partner: UNT College of Arts and Sciences
open access

Phage Hunters Advancing Genomics and Evolutionary Science (PHAGES): Implementing a Research-based Course for Freshmen at the University of North Texas

Description: Paper describes the Phage Hunters Advancing Genomics and Evolutionary Science (PHAGES) program from the Howard Hughes Medical Institute’s Science Education Alliance as implemented at the University of North Texas.
Date: 2012
Creator: Hughes, Lee E. & Benjamin, Robert C.
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Partner: UNT Libraries
open access

Modelling spatial concordance between Rocky Mountain spotted fever disease incidence and habitat probability of its vector Dermacentor variabilis (American dog tick)

Description: This article reports on the development and comparison of two maps of Texas related to Rocky Mountain spotted fever.
Date: November 1, 2012
Creator: Atkinson, Samuel F.; Sarkar, Sahotra; Avina, Aldo; Schuermann, Jim A. & Williamson, Phillip C.
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Partner: UNT College of Arts and Sciences
open access

An UPLC-ESI-MS/MS Assay Using 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate Derivatization for Targeted Aminio Acid Analysis: Application to Screening of Arabidopsis thaliana Mutants

Description: This article presents a method that enables thirty-eight metabolites (proteinogenic amino acids and related compounds) to be analyzed, with an improved sensitivity of 1 to 5 orders of magnitude compared to existing methods.
Date: July 6, 2012
Creator: Salazar, Carolina; Armenta, Jenny M. & Shulaev, Vladimir
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Partner: UNT College of Arts and Sciences
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