Description: The mechanism whereby insulin lowers the blood glucose concentration is currently under extensive investigation. Despite the general agreement that the addition of insulin increases glucose uptake by various isolated tissues, the question has been raised whether administered insulin produces its blood sugar lowering effect in vivo primarily in increasing glucose uptake. Furthermore, it has been suggested that physiologically-released insulin may not exert the same effects as are produced by administered insulin. Attention has also been focused on whether insulin (exogenous or endogenous) exerts its action mainly or entirely on the liver and to what extent insulin influences glucose uptake and glucose production by the liver. The studies to be reported are a continuation of earlier work and are concerned with the effects of insulin, both exogenous and endogenous, on glucose utilization by the tissues and glucose production by the liver under various dietary condition in the unanethetized, intact dog, using C¹⁴ glucose.
Creator: de Bodo, R. C.; Steele, R.; Altszuler, N.; Dunn, A. & Bishop, J. S.
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