Machine-learning models for Alzheimer’s disease diagnosis using neuroimaging data: survey, reproducibility, and generalizability evaluation
Description:
Article reviews the major preprocessing, data‑management, machine‑learning, and deep‑learning approaches used for Alzheimer’s disease diagnosis from multimodal neuroimaging data, highlighting the persistent inability of current methods to distinguish stable from progressive MCI and their limited clinical adoption. Article shows through a reproducibility study that open‑source ML models lose generalizability across cohorts even under controlled conditions, underscoring key methodological challen…
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Date:
March 21, 2025
Creator:
Aghdam, Maryam Akhavan; Bozdag, Serdar & Saeed, Farad
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Partner:
UNT College of Engineering